Naphthylpiperazine

	Naphthylpiperazine Naphthylpiperazine (NP) may refer to: * 1-(1-Naphthyl)piperazine (1-NP) * 1-(2-Naphthyl)piperazine (2-NP) Arylpiperazines Naphthalenes {{Short pages monitor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	1-(2-Naphthyl)piperazine 1-(2-Naphthyl)piperazine (2-NP), also known as 1-deazaquipazine, is a serotonin receptor modulator and putative serotonergic psychedelic of the arylpiperazine family related to quipazine. It shows affinity for the serotonin 5-HT1, 5-HT2, and 5-HT3 receptors and is known to act as a serotonin 5-HT2A receptor partial agonist. Conversely, it has negligible affinity for the serotonin 5-HT1D receptor. The drug produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents, although it was less efficacious than quipazine. This effect was absent in serotonin 5-HT2A receptor knockout mice. In addition, 2-NP fully generalizes to the psychedelic DOM in animal drug discrimination tests. Hence, it may have hallucinogenic effects in humans. Along with quipazine, the drug is one of a relatively small number of known psychedelics that is distinct from the tryptamine, phenethylamine, and lysergamide families. It was first described in the scientific literature by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	1-(1-Naphthyl)piperazine 1-(1-Naphthyl)piperazine (1-NP) is a drug which is a phenylpiperazine derivative. It acts as a non- selective, mixed serotonergic agent, exerting partial agonism at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F receptors, while antagonizing the 5-HT2A, 5-HT2B, and 5-HT2C receptors. It has also been shown to possess high affinity for the 5-HT3, 5-HT5A, 5-HT6, and 5-HT7 receptors, and may bind to 5-HT4 and the SERT as well. In animals it produces effects including hyperphagia, hyperactivity, and anxiolysis, of which are all likely mediated predominantly or fully by blockade of the 5-HT2C receptor. Derivatives of naphthylpiperazine include CSP-2503, F-11,461, S-14506, and S-14671. See also * 1-(2-Naphthyl)piperazine (2-NP) * Substituted piperazine * Diphenylpiperazine * Phenylpiperazine * Quipazine Quipazine, also known as 1-(2-quinolinyl)piperazine (2-QP), is a serotonin, serotonergic drug of the arylpiperazine family and an structural analog, analogue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Arylpiperazines Substituted piperazines are a class of chemical compounds based on a piperazine core. Some are used as recreational drugs and some are used in scientific research. List of substituted piperazines Benzylpiperazines File:Benzylpiperazine.svg, 1-Benzylpiperazine (BZP) File:Methylbenzylpiperazine.svg, 1-Methyl-4-benzylpiperazine (MBZP) File:DBZP.svg, 1,4-Dibenzylpiperazine (DBZP) File:MDBZP.svg, 3,4-Methylenedioxy-1-benzylpiperazine (MDBZP) File:2C-B-BZP.svg, 4-Bromo-2,5-dimethoxy-1-benzylpiperazine (2C-B-BZP) File:Methoxypiperamide.png, Methoxypiperamide (MeOP, MEXP) ((4-methoxyphenyl)(4-methylpiperazin-1-yl)methanone) File:Sunifiram.svg , Sunifiram (1-benzoyl-4-propanoylpiperazine) File:3-Methylbenzylpiperazine structure.png, 3-Methylbenzylpiperazine (3-MeBZP) File:Befuraline.svg, Befuraline(also produces benzylpiperazine as a metabolite) File:Fipexide.svg, Fipexide(also produces substituted benzylpiperazine as a metabolite) File:Piberaline.svg, Piberaline(also produces benzylp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]