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Lymphoma In Animals
Lymphoma (lymphosarcoma) in animals is a type of cancer defined by a proliferation of malignant lymphocytes within solid organs such as the lymph nodes, bone marrow, liver and spleen. The disease also may occur in the eye, skin, and gastrointestinal tract. Lymphoma in dogs Lymphoma is one of the most common malignant tumors to occur in dogs. The cause is genetic, but there are also suspected environmental factors involved, including in one study an increased risk with the use of the herbicide 2,4-D. This risk was not confirmed in another study. Breeds that are commonly affected include Boxer, Scottish Terrier, Basset Hound, Airedale Terrier, Chow Chow, German Shepherd, Poodle, St. Bernard, Bulldog, Beagle, Rottweiler and Golden Retriever. The Golden Retriever is especially susceptible to developing lymphoma, with a lifetime risk of 1:8. Classification The cancer is classified into low and high grade types. Classification is also based on location. The four location t ...
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Lymphoma In Golden
Lymphoma is a group of blood and lymph tumors that develop from lymphocytes (a type of white blood cell). In current usage the name usually refers to just the cancerous versions rather than all such tumours. Signs and symptoms may include enlarged lymph nodes, fever, drenching sweats, unintended weight loss, itching, and constantly feeling tired. The enlarged lymph nodes are usually painless. The sweats are most common at night. Many subtypes of lymphomas are known. The two main categories of lymphomas are the non-Hodgkin lymphoma (NHL) (90% of cases) and Hodgkin lymphoma (HL) (10%). The World Health Organization (WHO) includes two other categories as types of lymphoma – multiple myeloma and immunoproliferative diseases. Lymphomas and leukemias are a part of the broader group of tumors of the hematopoietic and lymphoid tissues. Risk factors for Hodgkin lymphoma include infection with Epstein–Barr virus and a history of the disease in the family. Risk factors for common ...
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Basset Hound
The Basset Hound is a short-legged breed of dog in the hound family. The Basset is a scent hound that was originally bred for the purpose of hunting hare. Their sense of smell and ability to ''ground-scent'' is second only to the Bloodhound.Hart, Ernest H. ''This Is the Basset Hound'', T.F.H. Books, 1974. Basset Hounds are one of six recognized " basset"-type breeds in France. The name ''Basset'' is derived from the French word ''bas'', meaning 'low', with the attenuating suffix ''-et''—together meaning 'rather low'. Basset Hounds are usually bicolours or tricolours of standard hound coloration. Description Appearance Bassets are large, short, solid and long, with curved sabre tails held high over their long backs. An adult dog weighs between . This breed, relative to its size, is heavier-boned than any other. This breed, like its ancestor the Bloodhound, has a hanging skin structure, which causes the face to tend to have a sad look; this, for many people, adds to the ...
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Thymus
The thymus is a specialized primary lymphoid organ of the immune system. Within the thymus, thymus cell lymphocytes or '' T cells'' mature. T cells are critical to the adaptive immune system, where the body adapts to specific foreign invaders. The thymus is located in the upper front part of the chest, in the anterior superior mediastinum, behind the sternum, and in front of the heart. It is made up of two lobes, each consisting of a central medulla and an outer cortex, surrounded by a capsule. The thymus is made up of immature T cells called thymocytes, as well as lining cells called epithelial cells which help the thymocytes develop. T cells that successfully develop react appropriately with MHC immune receptors of the body (called ''positive selection'') and not against proteins of the body (called ''negative selection''). The thymus is largest and most active during the neonatal and pre-adolescent periods. By the early teens, the thymus begins to decrease in size a ...
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Central Nervous System
The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord. The CNS is so named because the brain integrates the received information and coordinates and influences the activity of all parts of the bodies of bilaterally symmetric and triploblastic animals—that is, all multicellular animals except sponges and diploblasts. It is a structure composed of nervous tissue positioned along the rostral (nose end) to caudal (tail end) axis of the body and may have an enlarged section at the rostral end which is a brain. Only arthropods, cephalopods and vertebrates have a true brain (precursor structures exist in onychophorans, gastropods and lancelets). The rest of this article exclusively discusses the vertebrate central nervous system, which is radically distinct from all other animals. Overview In vertebrates, the brain and spinal cord are both enclosed in the meninges. The meninges provide a barrier to chemicals di ...
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Gastrointestinal
The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organs of the digestive system, in humans and other animals, including the esophagus, stomach, and intestines. Food taken in through the mouth is digested to extract nutrients and absorb energy, and the waste expelled at the anus as feces. ''Gastrointestinal'' is an adjective meaning of or pertaining to the stomach and intestines. Most animals have a "through-gut" or complete digestive tract. Exceptions are more primitive ones: sponges have small pores ( ostia) throughout their body for digestion and a larger dorsal pore ( osculum) for excretion, comb jellies have both a ventral mouth and dorsal anal pores, while cnidarians and acoels have a single pore for both digestion and excretion. The human gastrointestinal tract consists of the esophagus, stomach, and intestines, and is ...
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Mediastinum
The mediastinum (from ) is the central compartment of the thoracic cavity. Surrounded by loose connective tissue, it is an undelineated region that contains a group of structures within the thorax, namely the heart and its vessels, the esophagus, the trachea, the phrenic and cardiac nerves, the thoracic duct, the thymus and the lymph nodes of the central chest. Anatomy The mediastinum lies within the thorax and is enclosed on the right and left by pleurae. It is surrounded by the chest wall in front, the lungs to the sides and the spine at the back. It extends from the sternum in front to the vertebral column behind. It contains all the organs of the thorax except the lungs. It is continuous with the loose connective tissue of the neck. The mediastinum can be divided into an upper (or superior) and lower (or inferior) part: * The superior mediastinum starts at the superior thoracic aperture and ends at the thoracic plane. * The inferior mediastinum from this level ...
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Grading (tumors)
In pathology, grading is a measure of the cell appearance in tumors and other neoplasms. Some pathology grading systems apply only to malignant neoplasms (cancer); others apply also to benign neoplasms. The neoplastic grading is a measure of cell anaplasia (reversion of differentiation) in the sampled tumor and is based on the resemblance of the tumor to the tissue of origin. Grading in cancer is distinguished from staging, which is a measure of the extent to which the cancer has spread. Pathology grading systems classify the microscopic cell appearance abnormality and deviations in their rate of growth with the goal of predicting developments at tissue level (see also the 4 major histological changes in dysplasia). Cancer is a disorder of cell life cycle alteration that leads (non-trivially) to excessive cell proliferation rates, typically longer cell lifespans and poor differentiation. The grade score (numerical: G1 up to G4) increases with the lack of cellular differentiatio ...
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Golden Retriever
The Golden Retriever is a Scottish breed of retriever dog of medium size. It is characterised by a gentle and affectionate nature and a striking golden coat. It is commonly kept as a pet and is among the most frequently registered breeds in several Western countries. It is a frequent competitor in dog shows and obedience trials; it is also used as a gundog, and may be trained for use as a guide dog. The breed was created by Sir Dudley Marjoribanks at his Scottish estate Guisachan in the late nineteenth century. He cross-bred Flat-coated Retrievers with Tweed Water Spaniels, with some further infusions of Red Setter, Labrador Retriever and Bloodhound. The breed was recognised by the Kennel Club in 1913, and during the interwar period spread to many parts of the world. History The Golden Retriever was developed in Scotland in the nineteenth century by Sir Dudley Marjoribanks (later to become Baron Tweedmouth) from Flat-coated Retrievers judiciously crossed wit ...
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Rottweiler
The Rottweiler (, ) is a breed of domestic dog, regarded as medium-to-large or large. The dogs were known in German as , meaning Rottweil butchers' dogs, because their main use was to herd livestock and pull carts laden with butchered meat to market. This continued until the mid-19th century when railways replaced droving. Although still used to herd stock in many parts of the world, Rottweilers are now also used as search and rescue dogs, guard dogs, and police dogs.Adolf Pienkoss, ''The Rottweiler'', 3rd ed., Borken, Germany: Internationale Föderation der Rottweilerfreunde, 2008. History According to the FCI Standard, the Rottweiler is considered to be one of the oldest surviving dog breeds. Its origin goes back to Roman times. These dogs were kept as herder or driving dogs. They marched over the Alps with the Roman legions, protecting the humans and driving their cattle. In the region of Rottweil, these dogs met and mixed with the native dogs in a natural crossing. ...
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Beagle
The beagle is a breed of small scent hound, similar in appearance to the much larger foxhound. The beagle was developed primarily for hunting hare, known as beagling. Possessing a great sense of smell and superior tracking instincts, the beagle is the primary breed used as a detection dog for prohibited agricultural imports and foodstuffs in quarantine around the world. The beagle is intelligent and is a popular pet due to its size, good temper, and a lack of inherited health problems. The modern breed was developed in Great Britain around the 1830s from several breeds, including the Talbot Hound, the North Country Beagle, the Southern Hound, and possibly the Harrier. Beagles have been depicted in popular culture since Elizabethan times in literature and paintings and more recently in film, television, and comic books. History The origin of the beagle is not known. In the 11th century, William the Conqueror brought the St. Hubert Hound and the Talbot hound to ...
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Bulldog
The Bulldog is a British breed of dog of mastiff type. It may also be known as the English Bulldog or British Bulldog. It is of medium size, a muscular, hefty dog with a wrinkled face and a distinctive pushed-in nose."Get to Know the Bulldog"
, 'The American Kennel Club'. Retrieved 29 May 2014
It is commonly kept as a ; in 2013 it was in twelfth place on a list of the breeds most frequently registered worldwide. The Bulldog has a longstanding association with British culture; the BB ...
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Poodle
The Poodle, called the Pudel in German and the Caniche in French, is a breed of water dog. The breed is divided into four varieties based on size, the Standard Poodle, Medium Poodle, Miniature Poodle and Toy Poodle, although the Medium Poodle variety is not universally recognised. They have a distinctive thick, curly coat, and come in many colors, with only solid ones recognized by breed registries. While a reasonably healthy breed, they are prone to sebaceous adenitis and Addison's disease among other genetic disorders. The Poodle most likely originated in Germany, although the Fédération Cynologique Internationale and a minority of cynologists believe it originated in France. Similar dogs date back to at least the 17th century, and it was first recognized by a kennel club in 1874. The Standard Poodle was originally used by wildfowl hunters to retrieve game from water. The smaller varieties of the breed were bred from in France, where they were once commonly used as circus p ...
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