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Human Herpesvirus 6A
Human herpesvirus 6A (HHV-6A) is a species of virus in the genus ''Roseolovirus'', subfamily ''Betaherpesvirinae'', family ''Herpesviridae'', and order ''Herpesvirales''. HHV-6A and infertility * A 2016 study showed that 43% of women with unexplained infertility tested positive for HHV-6A while 0% of women in the fertile control group tested positive. HHV-6A was found present in endrometrial epithelial cells from women with unexplained infertility. * A 2018 study reports the prevalence of HHV-6A in endometrial biopsies among women experiencing recurrent implantation failure after IVF/ET compared to control groups. * A 2019 study confirmed the presence of HHV-6A infection in 40% of idiopathic infertile women. Identifying the effect of HHV-6A infection on endometrial immune status opens up a new perspectives on fertility care. It's possible to choose antiviral therapies and non-hormonal approaches for women with unexplained infertility characterized by HHV-6A to increase their ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Roseolovirus
''Roseolovirus'' is a genus of viruses in the order ''Herpesvirales'', in the family ''Herpesviridae'', in the subfamily ''Betaherpesvirinae''. There are currently six species in this genus. Diseases associated with this genus include: HHV-6: sixth disease (roseola infantum, exanthema subitum); HHV-7: symptoms analog to the 'sixth disease'. Species The genus consists of the following six species: * '' Roseolovirus humanbeta7'' * '' Roseolovirus humanbeta6a'' * '' Roseolovirus humanbeta6b'' * '' Roseolovirus macacinebeta9'' * '' Roseolovirus muridbeta3'' * '' Roseolovirus suidbeta2'' Structure Viruses in ''Roseolovirus'' are enveloped, with icosahedral, spherical to pleomorphic, and round geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and non-segmented, around 200kb in length. Life cycle Viral replication is nuclear, and is lysogenic. Entry into the host cell is achieved by attachment of the viral glycoproteins to host recepto ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Betaherpesvirinae
''Betaherpesvirinae'' is a subfamily of viruses in the order '' Herpesvirales'' and in the family ''Herpesviridae''. Mammals serve as natural hosts. There are 26 species in this subfamily, divided among 5 genera. Diseases associated with this subfamily include: human cytomegalovirus (HHV-5): congenital CMV infection; HHV-6: ' sixth disease' (also known as ''roseola infantum'' or ''exanthem subitum''); HHV-7: symptoms analogous to the 'sixth disease'. Genera ''Betaherpesvirinae'' consists of the following five genera: * ''Cytomegalovirus'' * '' Muromegalovirus'' * '' Proboscivirus'' * '' Quwivirus'' * '' Roseolovirus'' Structure Viruses in ''Betaherpesvirinae'' are enveloped, with icosahedral, spherical to pleomorphic, and Round geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and non-segmented, around 140-240kb in length. Life cycle Viral replication is nuclear, and is lysogenic. Entry into the host cell is achieved by attachme ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Herpesviridae
''Orthoherpesviridae'', previously named and more widely known as ''Herpesviridae'', is a large family of DNA viruses that cause infections and certain diseases in animals, including humans. The members of this family are commonly known as herpesviruses. The family name is derived from the Greek word ἕρπειν ( 'to creep'), referring to spreading cutaneous lesions, usually involving blisters, seen in flares of herpes simplex 1, herpes simplex 2 and herpes zoster ( shingles). In 1971, the International Committee on the Taxonomy of Viruses (ICTV) established ''Herpesvirus'' as a genus with 23 viruses among four groups. Since then, the number of identified herpesviruses has grown to more than 100. Herpesviruses can cause both latent and lytic infections. Nine herpesvirus types are known to primarily infect humans, at least five of which are extremely widespread among most human populations, and which cause common diseases: herpes simplex 1 and 2 (HSV-1 and HSV-2, also know ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Herpesvirales
''Herpesvirales'' is an order of dsDNA viruses (Baltimore group I) with animal hosts, characterised by a common morphology consisting of an icosahedral capsid enclosed in a glycoprotein-containing lipid envelope. Common infections in humans caused by members of this order include cold sores, genital herpes, chickenpox, shingles, and glandular fever. ''Herpesvirales'' is the sole order in the class ''Herviviricetes'', which is the sole class in the phylum ''Peploviricota''. Virology Morphology All members of the order have a virion structure that consists of a DNA core surrounded by an icosahedral capsid composed of 12 pentavalent and 150 hexavalent capsomeres (T = 16). The capsid has a diameter of ~110 nanometers (nm) and is embedded in a proteinaceous matrix called the tegument, which in its turn is enclosed by a glycoprotein-containing lipid envelope with a diameter of about 200 nm. The DNA genome is linear and double stranded, with sizes in the range 125–290 kbp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Herpesvirus 6
Human herpesvirus 6 (HHV-6) is the common collective name for human herpesvirus 6A (HHV-6A) and human herpesvirus 6B (HHV-6B). These closely related viruses are two of the nine known herpesviruses that have humans as their primary host. HHV-6A and HHV-6B are double-stranded DNA viruses within the ''Betaherpesvirinae'' subfamily and of the genus '' Roseolovirus''. HHV-6A and HHV-6B infect almost all of the human populations that have been tested. HHV-6A has been described as more neurovirulent, and as such is more frequently found in patients with neuroinflammatory diseases such as multiple sclerosis. HHV-6 (and HHV-7) levels in the brain are also elevated in people with Alzheimer's disease. HHV-6B primary infection is the cause of the common childhood illness exanthema subitum (also known as roseola infantum or sixth disease). It is passed on from child to child. It is uncommon for adults to contract this disease as most people have had it by kindergarten, and once contract ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Committee On Taxonomy Of Viruses
The International Committee on Taxonomy of Viruses (ICTV) authorizes and organizes the taxonomic classification of and the nomenclature for viruses. The ICTV develops a universal taxonomic scheme for viruses, and thus has the means to appropriately describe, name, and classify every virus taxon. The members of the International Committee on Taxonomy of Viruses are considered expert virologists. The ICTV was formed from and is governed by the Virology Division of the International Union of Microbiological Societies. Detailed work, such as identifying new taxa and delimiting the boundaries of species, genera, families, etc. typically is performed by study groups of experts in the families. History The International Committee on Nomenclature of Viruses (ICNV) was established in 1966, at the International Congress for Microbiology in Moscow, to standardize the naming of virus taxa. The ICVN published its first report in 1971. For viruses infecting vertebrates, the first report i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paraphyly
Paraphyly is a taxonomic term describing a grouping that consists of the grouping's last common ancestor and some but not all of its descendant lineages. The grouping is said to be paraphyletic ''with respect to'' the excluded subgroups. In contrast, a monophyletic grouping (a clade) includes a common ancestor and ''all'' of its descendants. The terms are commonly used in phylogenetics (a subfield of biology) and in the tree model of historical linguistics. Paraphyletic groups are identified by a combination of synapomorphies and symplesiomorphies. If many subgroups are missing from the named group, it is said to be polyparaphyletic. The term received currency during the debates of the 1960s and 1970s accompanying the rise of cladistics, having been coined by zoologist Willi Hennig to apply to well-known taxa like Reptilia (reptiles), which is paraphyletic with respect to birds. Reptilia contains the last common ancestor of reptiles and all descendants of that ancest ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
