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Graded Exercise Therapy
Graded exercise therapy (GET) is a programme of physical activity that starts very slowly and gradually increases over time, intended as a treatment for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Most public health bodies, including the CDC and NICE, consider it ineffective, and its safety is disputed. However, GET still enjoys support from a minority of clinicians and organizations. Description A graded exercise programme starts with a physiotherapist or exercise physiologist assessing the patient's current abilities and negotiating goals. The patient then begins exercising at a level within their capabilities. The patient and therapist increase the duration of sessions, typically by 10-20% every 1-2 weeks, until they can perform 30 minutes of light exercise five times a week. Then the intensity is raised if desired. The exercise can be any activity that can be titrated, such as walking, jogging, swimming, using exercise machines, and these may be mixed to ad ...
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Physical Therapy
Physical therapy (PT), also known as physiotherapy, is a healthcare profession, as well as the care provided by physical therapists who promote, maintain, or restore health through patient education, physical intervention, disease prevention, and health promotion. Physical therapist is the term used for such professionals in the United States, and physiotherapist is the term used in many other countries. The career has many specialties including musculoskeletal, orthopedics, cardiopulmonary, neurology, endocrinology, sports medicine, geriatrics, pediatrics, women's health, wound care and electromyography. PTs practice in many settings, both public and private. In addition to clinical practice, other aspects of physical therapy practice include research, education, consultation, and health administration. Physical therapy is provided as a primary care treatment or alongside, or in conjunction with, other medical services. In some jurisdictions, such as the United Kin ...
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PACE Trial Subjective Outcomes
Pace or paces may refer to: Business *Pace (transit), a bus operator in the suburbs of Chicago, US *Pace Airlines, an American charter airline * Pace Foods, a maker of a popular brand of salsa sold in North America, owned by Campbell Soup Company * Pace Membership Warehouse, a defunct American retail chain *Pace plc, a British electronics company * Pace Savings & Credit Union, a Canadian credit union * Pace Shopping Mall, a series of shopping mall complexes in Pakistan Education in the United States *Pace University, New York *Pace University High School, New York *Pace Academy, a private secondary school in Atlanta, Georgia *Monsignor Edward Pace High School, a Catholic high school in Miami Gardens, Florida People *Pace (surname), shared by various people *Paces (musician) from Australia Places *Pace, Florida, a census-designated place, United States * Pace, Mississippi, a town, United States * Paces, Virginia, an unincorporated community, United States * Pace, Podlaskie Voivo ...
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Long COVID
Long may refer to: Measurement * Long, characteristic of something of great duration * Long, characteristic of something of great length * Longitude (abbreviation: long.), a geographic coordinate * Longa (music), note value in early music mensural notation Places Asia * Long District, Laos * Long District, Phrae, Thailand * Longjiang (other) or River Long (lit. "dragon river"), one of several rivers in China * Yangtze River or Changjiang (lit. "Long River"), China Elsewhere * Long, Somme, France People * Long (Chinese surname) * Long (Western surname) Fictional characters * Long (''Bloody Roar''), in the video game series * Long, Aeon of Permanence in Honkai: Star Rail Sports * Long, a fielding term in cricket * Long, in tennis and similar games, beyond the service line during a serve and beyond the baseline during play Other uses * , a U.S. Navy ship name * Long (finance), a position in finance, especially stock markets * Lòng, name for a laneway in Sh ...
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ME Association
The ME Association is a UK health charitable organization that provides information, advocacy, and services to persons and families affected by ME/CFS (Myalgic encephalomyelitis/chronic fatigue syndrome), and raises funds for research into ME/CFS. It has been reported to be one of the two largest UK charities for ME/CFS. Activities The organisation informs its members of developments affecting sufferers, carers, family and friends, via its quarterly magazine ME Essential, its website, and other communication media. It promotes its members' interests in medical and political arenas, and in the media. It produces advice on specific aspects of the illness and its effect on sufferers, particularly in its clinical guidance booklet, 'ME/CFS/PVFS : An exploration of the key clinical issues', which informs both practitioners and patients. As of 2005, persons with ME/CFS in the UK still had difficulty obtaining treatment literature from their General Practitioners' surgeries. A majority ...
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Clinical Descriptions Of Chronic Fatigue Syndrome
Clinical descriptions of ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) vary. Different groups have produced sets of diagnostic criteria that share many similarities. The biggest differences between criteria are whether post-exertional malaise (PEM) is required, and the number of symptoms needed. The pathology of ME/CFS is poorly understood, and it can be a difficult condition to diagnose because there is no standard test, many symptoms are non-specific, and because doctors and patients may be unfamiliar with post-exertional malaise. Subgroup analysis suggests that, depending on the applied definition, CFS may represent a variety of conditions rather than a single disease entity. Definitions 2015 IOM criteria The IOM criteria come from the IOM's 2015 report on CFS, and the CDC currently uses this definition. The IOM criteria require the following three symptoms: * Severe, disabling fatigue of new onset * Post-exertional malaise (PEM) * Unrefreshing sleep. Al ...
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Cochrane (organisation)
Cochrane is a British international charitable organisation formed to synthesize medical research findings to facilitate evidence-based choices about health interventions involving health professionals, patients and policy makers. It includes 53 review groups that are based at research institutions worldwide. Cochrane has over volunteer experts from around the world. The group conducts systematic reviews of healthcare interventions and diagnostic tests and publishes them in the Cochrane Library. While Cochrane reviews typically focus on randomized controlled trials, some reviews, particularly in areas such as public and occupational health, also incorporate other study designs. These may include non-randomised observational studies as well as controlled before–after (CBA) studies and interrupted time-series studies. According to the Library, articles are available via one-click access, though some may require registration or a subscription. History Cochrane, prev ...
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Outcome Switching
Outcome switching is the practice of changing the primary or secondary outcomes of a clinical trial after its initiation. An outcome is the goal of the clinical trial, such as survival after five years for cancer treatment. Outcome switching can lead to bias and undermine the reliability of the trial, for instance when outcomes are switched after researchers already have access to trial data. That way, researchers can cherry pick an outcome which is statistically significant. Problem Outcome switching can undermine the reliability of the trial, for instance when outcomes are switched when researchers already have access to the trial data. It can lead to bias in terms of benefits and harms. For example, when the findings using the original protocol were statistically insignificant, a study may cherry pick a new outcome measure that is statistically significant. If there are a large number of outcomes to choose from, it is likely at least one will show significant findings, a ...
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Cognitive Behavioral Therapy
Cognitive behavioral therapy (CBT) is a form of psychotherapy that aims to reduce symptoms of various mental health conditions, primarily depression, PTSD, and anxiety disorders. Cognitive behavioral therapy focuses on challenging and changing cognitive distortions (thoughts, beliefs, and attitudes) and their associated behaviors in order to improve emotional regulation and help the individual develop coping strategies to address problems. Though originally designed as an approach to treat depression, CBT is often prescribed for the evidence-informed treatment of many mental health and other conditions, including anxiety, substance use disorders, marital problems, ADHD, and eating disorders. CBT includes a number of cognitive or behavioral psychotherapies that treat defined psychopathologies using evidence-based techniques and strategies. CBT is a common form of talk therapy based on the combination of the basic principles from behavioral and cognitive psychology. I ...
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PACE Trial
The PACE trial was a large and controversial trial which compared the effects of cognitive behavioural therapy (CBT), graded exercise therapy (GET), adaptive pacing therapy, and specialist medical care for people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The investigators reported that both CBT and GET were “moderately” effective at treating ME/CFS. The results have been questioned due to methodological weaknesses in the study design. For instance, the definition of recovery was weakened after the data was collected, leading to a larger share of recovered participants. Analyses under the original protocol did not find significant effects and concluded that GET is potentially unsafe for patients with ME/CFS. As of 2021, graded exercise therapy and cognitive behavioural therapy (intended as a treatment) are no longer recommended by the National Institute for Health and Care Excellence for people with ME/CFS. Initial study and findings The £5 million t ...
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Royal Australian College Of General Practitioners
Royal may refer to: People * Royal (name), a list of people with either the surname or given name * A member of a royal family or royalty Places United States * Royal, Arkansas, an unincorporated community * Royal, Illinois, a village * Royal, Iowa, a city * Royal, Missouri, an unincorporated community * Royal, Nebraska, a village * Royal, Franklin County, North Carolina, an unincorporated area * Royal, Utah, a ghost town * Royal, West Virginia, an unincorporated community * Royal Gorge, on the Arkansas River in Colorado * Royal Township (other) Elsewhere * Mount Royal, a hill in Montreal, Canada * Royal Canal, Dublin, Ireland * Royal National Park, New South Wales, Australia Arts, entertainment, and media * ''Royal'' (Jesse Royal album), 2021 * Royal (Ayo album), 2020 * '' The Royal'', a British medical drama television series * '' The Royal Magazine'', a monthly British literary magazine published between 1898 and 1939 * '' The Raja Saab'', working ti ...
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Myalgic Encephalomyelitis/chronic Fatigue Syndrome
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling Chronic condition, chronic illness. People with ME/CFS experience profound fatigue that does not go away with rest, as well as sleep issues and problems with memory or concentration. The Pathognomonic, hallmark symptom is post-exertional malaise (PEM), a worsening of the illness which can start immediately or hours to days after even minor physical or mental activity. This "crash" can last from hours or days to several months. Further common symptoms include orthostatic intolerance, dizziness or faintness when upright and pain. The cause of the disease is unknown. ME/CFS often starts after an infection, such as infectious mononucleosis, mononucleosis. It can run in families, but no genes that contribute to ME/CFS have been confirmed. ME/CFS is associated with changes in the nervous and immune systems, as well as in energy production. Diagnosis is based on distinctive symptoms, and a differential diag ...
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Mayo Clinic
Mayo Clinic () is a Nonprofit organization, private American Academic health science centre, academic Medical centers in the United States, medical center focused on integrated health care, healthcare, Mayo Clinic College of Medicine and Science, education, and research. It maintains three major campuses in Rochester, Minnesota; Jacksonville, Florida; and Phoenix, Arizona, Phoenix/Scottsdale, Arizona. Mayo Clinic employs over 7,300 physicians and scientists, along with another 66,000 administrative and allied health staff. The practice specializes in treating difficult cases through Health care#Tertiary care, tertiary care and Medical tourism#United States, destination medicine. It is home to the top-15 ranked Mayo Clinic Alix School of Medicine in addition to many of the highest regarded residency education programs in the United States. It spends over $660 million a year on research and has more than 3,000 full-time research personnel. William Worrall Mayo settled his family i ...
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