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Fungal Diseases
Pathogenic fungi are fungi A fungus (: fungi , , , or ; or funguses) is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and mold (fungus), molds, as well as the more familiar mushrooms. These organisms are classified as one ... that cause disease in humans or other organisms. Although fungi are eukaryotic, many pathogenic fungi are microorganisms. Approximately 300 fungi are known to be pathogenic to humans; their study is called "medical mycology". Fungal infections are estimated to kill more people than either tuberculosis or malaria—about two million people per year. In 2022 the World Health Organization (WHO) published a list of fungal pathogens which should be a priority for public health action. Markedly more fungi are known to be pathogenic to plant life than those of the Animal, animal kingdom. The study of fungi and other organisms pathogenic to plants is called plant pathology. Pathogens of particular concern Accordi ...
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Fungi
A fungus (: fungi , , , or ; or funguses) is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and mold (fungus), molds, as well as the more familiar mushrooms. These organisms are classified as one of the kingdom (biology)#Six kingdoms (1998), traditional eukaryotic kingdoms, along with Animalia, Plantae, and either Protista or Protozoa and Chromista. A characteristic that places fungi in a different kingdom from plants, bacteria, and some protists is chitin in their cell walls. Fungi, like animals, are heterotrophs; they acquire their food by absorbing dissolved molecules, typically by secreting digestive enzymes into their environment. Fungi do not photosynthesize. Growth is their means of motility, mobility, except for spores (a few of which are flagellated), which may travel through the air or water. Fungi are the principal decomposers in ecological systems. These and other differences place fungi in a single group of related o ...
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Gut Flora
Gut microbiota, gut microbiome, or gut flora are the microorganisms, including bacteria, archaea, fungi, and viruses, that live in the digestive tracts of animals. The gastrointestinal metagenome is the aggregate of all the genomes of the gut microbiota. The gut is the main location of the human microbiome. The gut microbiota has broad impacts, including effects on colonization, resistance to pathogens, maintaining the intestinal epithelium, metabolizing dietary and pharmaceutical compounds, controlling immune function, and even behavior through the gut–brain axis. The microbial composition of the gut microbiota varies across regions of the digestive tract. The colon contains the highest microbial density of any human-associated microbial community studied so far, representing between 300 and 1000 different species. Bacteria are the largest and to date, best studied component and 99% of gut bacteria come from about 30 or 40 species. About 55% of the dry mass of feces ...
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Aspergillus Fumigatus
''Aspergillus fumigatus'' is a species of fungus in the genus ''Aspergillus'', and is one of the most common ''Aspergillus'' species to cause disease in individuals with an immunodeficiency. ''Aspergillus fumigatus'', a saprotroph widespread in nature, is typically found in soil and decaying organic matter, such as compost heaps, where it plays an essential role in carbon and nitrogen recycling. Colonies of the fungus produce from conidiophores; thousands of minute grey-green conidia (2–3 μm) which readily become airborne. For many years, ''A. fumigatus'' was thought to only reproduce asexually, as neither mating nor meiosis had ever been observed. In 2008, ''A. fumigatus'' was shown to possess a fully functional sexual reproductive cycle, 145 years after its original description by Fresenius. Although ''A. fumigatus'' occurs in areas with widely different climates and environments, it displays low genetic variation and a lack of population genetic differentiation on a global s ...
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Pulmonary Aspergillosis
The lungs are the primary organs of the respiratory system in many animals, including humans. In mammals and most other tetrapods, two lungs are located near the backbone on either side of the heart. Their function in the respiratory system is to extract oxygen from the atmosphere and transfer it into the bloodstream, and to release carbon dioxide from the bloodstream into the atmosphere, in a process of gas exchange. Respiration is driven by different muscular systems in different species. Mammals, reptiles and birds use their musculoskeletal systems to support and foster breathing. In early tetrapods, air was driven into the lungs by the pharyngeal muscles via buccal pumping, a mechanism still seen in amphibians. In humans, the primary muscle that drives breathing is the diaphragm. The lungs also provide airflow that makes vocalisation including speech possible. Humans have two lungs, a right lung and a left lung. They are situated within the thoracic cavity of the chest ...
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Burgess Publishing Company
Burgess may refer to: People and fictional characters * Burgess (surname), a list of people and fictional characters * Burgess (given name), a list of people Places Canada * Mount Burgess, a mountain in Yoho National Park, British Columbia England * Burgess Park, a park in London *Burgess Field, a nature reserve in Oxford *Burgess Hill, a town and parish in West Sussex United States * Burgess, Michigan, an unincorporated community *Burgess, Missouri, an unincorporated community * Burgess, South Carolina, an unincorporated community *Burgess, Virginia, an unincorporated community *Burgess Township, Bond County, Illinois, a township *Burgess Branch, a tributary of the Missisquoi River in Vermont Other uses *Burgess (title), a political official or representative *Burgess Company, an American airplane manufacturer *Burgess GAA, an athletic club in Ireland See also *Burgess House (other), several buildings named *Burgess model, or Concentric zone model, a theore ...
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Candida Guilliermondii
''Meyerozyma guilliermondii'' (formerly known as ''Pichia guilliermondii'' until its rename in 2010) is a species of yeast of the genus '' Meyerozyma'' whose asexual or anamorph In mycology, the terms teleomorph, anamorph, and holomorph apply to portions of the life cycles of fungi in the phyla Ascomycota and Basidiomycota: *Teleomorph: the sexual reproductive stage (morph), typically a fruiting body. *Anamorph: an ase ...ic form is known as ''Candida guilliermondii''. ''Candida guilliermondii'' has been isolated from numerous human infections, mostly of cutaneous origin, if only from immunosuppressed patients. ''C. guilliermondii'' has also been isolated from normal skin and in seawater, feces of animals, fig wasps, buttermilk, leather, fish, and beer. Morphology ''Candida guilliermondii'' colonies are flat, moist, smooth, and cream to yellow in color on Sabouraud dextrose agar. It does not grow on the surface when inoculated into Sabouraud broth. When grown on cornmeal ...
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Candida Parapsilosis
''Candida parapsilosis'' is a fungal species of yeast that has become a significant cause of sepsis and of wound and tissue infections in immunocompromised people. Unlike ''Candida albicans'' and ''Candida tropicalis'', ''C. parapsilosis'' is not an obligate human pathogen, having been isolated from nonhuman sources such as domestic animals, insects and soil. ''C. parapsilosis'' is also a normal human commensal and it is one of the fungi most frequently isolated from human hands. There are several risk factors that can contribute to ''C. parapsilosis'' colonization. Immunocompromised individuals and surgical patients, particularly those undergoing surgery of the gastrointestinal tract, are at high risk for infection with ''C. parapsilosis''. There is currently no consensus on the treatment of invasive candidiasis caused by ''C. parapsilosis'', although the therapeutic approach typically includes the removal of foreign bodies such as implanted prostheses and the administration of sy ...
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Candida Krusei
''Pichia kudriavzevii'' (formerly ''Candida krusei'') is a budding yeast (a species of fungus) involved in chocolate production. ''P. kudriavzevii'' is an emerging fungal nosocomial pathogen primarily found in the immunocompromised and those with hematological malignancies. It has natural resistance to fluconazole, a standard antifungal agent. It is most often found in patients who have had prior fluconazole exposure, sparking debate and conflicting evidence as to whether fluconazole should be used prophylactically. Mortality due to ''P. kudriavzevii'' fungemia is much higher than the more common ''C. albicans''. Other ''Candida'' species that also fit this profile are ''C. parapsilosis'', ''C. glabrata'', ''C. tropicalis'', ''C. guillermondii'' and ''C. rugosa''. ''P. kudriavzevii'' can be successfully treated with voriconazole, amphotericin'' ''B, and echinocandins (micafungin, caspofungin, and anidulafungin). Role in chocol ...
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C Pseudotropicalis
C, or c, is the third letter of the Latin alphabet, used in the modern English alphabet, the alphabets of other western European languages and others worldwide. Its name in English is ''cee'' (pronounced ), plural ''cees''. History "C" comes from the same letter as "G". The Semites named it gimel. The sign is possibly adapted from an Egyptian hieroglyph for a staff sling, which may have been the meaning of the name ''gimel''. Another possibility is that it depicted a camel, the Semitic name for which was ''gamal''. Barry B. Powell, a specialist in the history of writing, states "It is hard to imagine how gimel = "camel" can be derived from the picture of a camel (it may show his hump, or his head and neck!)". In the Etruscan language, plosive consonants had no contrastive voicing, so the Greek ' Γ' (Gamma) was adopted into the Etruscan alphabet to represent . Already in the Western Greek alphabet, Gamma first took a '' form in Early Etruscan, then '' in Classical E ...
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Candida Tropicalis
''Candida tropicalis'' is a species of yeast in the genus '' Candida''. It is a common pathogen in neutropenic hosts, in whom it may spread through the bloodstream to peripheral organs. For invasive disease, treatments include amphotericin B, echinocandins, or extended-spectrum triazole antifungals. History and taxonomy In the history of fungi, the name of genus ''Candida'', derived from the family Debaryomycetaceae, comes from the Latin term "" which has the meaning of “glowing white” and also refers to as smooth and glistening. Genus ''Candida'' referred to any asexual yeast without any of the following characteristics: production of acetic acid, pigments of colours red, pink or orange, arthroconidia, unipolar or bipolar budding, enteroblastic-basipetal budding, blastoconidia formation on sympodulae, buds formation on stalks, triangular cells, needle-shaped terminal conidia, and having the ability to grow on inositol as a sole carbon source. Although there are 200 spec ...
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Candida Stellatoidea
''Candida albicans'' is an opportunistic pathogenic yeast that is a common member of the human gut flora. It can also survive outside the human body. It is detected in the gastrointestinal tract and mouth in 40–60% of healthy adults. It is usually a commensal organism, but it can become pathogenic in immunocompromised individuals under a variety of conditions. It is one of the few species of the genus '' Candida'' that cause the human infection candidiasis, which results from an overgrowth of the fungus. Candidiasis is, for example, often observed in HIV-infected patients. ''C. albicans'' is the most common fungal species isolated from biofilms either formed on (permanent) implanted medical devices or on human tissue. ''C. albicans'', ''C. tropicalis'', ''C. parapsilosis'', and ''C. glabrata'' are together responsible for 50–90% of all cases of candidiasis in humans. A mortality rate of 40% has been reported for patients with systemic candidiasis due to ''C. albicans''. B ...
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Candida Auris
''Candidozyma auris'' is a species of fungus that grows as a yeast. It is one of the few species of the genus ''Candidozyma'' which cause candidiasis in humans. Often, candidiasis is hospital-acquired infection, acquired in hospitals by patients with Immunodeficiency, weakened immune systems. ''C.auris'' can cause invasive candidiasis (fungemia) in which the bloodstream, central nervous system, and internal Organ (anatomy), organs are infected. It has attracted widespread attention because of its multiple drug resistance. Treatment is also complicated because it is easily misidentified as other ''Candida'' species. ''Candidozyma auris'' was first described in 2009 after it was isolated from the ear canal of a 70-year-old Japanese woman at the Tokyo Metropolitan Geriatric Hospital in Japan. In 2011, South Korea had its first cases of disease-causing ''C.auris''. Reportedly, this spread across Asia and Europe, and first appeared in the U.S. in 2013. DNA analysis of four distinct ...
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