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Fibrocartilaginous
Fibrocartilage consists of a mixture of white fibrous tissue and Cartilage, cartilaginous tissue in various proportions. It owes its inflexibility and toughness to the former of these constituents, and its Elasticity (physics), elasticity to the latter. It is the only type of cartilage that contains type I collagen in addition to the normal Type II collagen, type II. Structure The extracellular matrix of fibrocartilage is mainly made from type I collagen secreted by Chondrocyte, chondroblasts. Locations of fibrocartilage in the human body * Symphysis, secondary cartilaginous joints: ** pubic symphysis ** annulus fibrosis of Intervertebral disc, intervertebral discs ** manubriosternal joint * glenoid labrum of shoulder joint * acetabular labrum of hip joint * medial and lateral Meniscus (anatomy), menisci of the knee joint * location where Tendon, tendons and Ligament, ligaments attach to bone * triangular fibrocartilage complex (UTFCC) Function Repair If hyaline cartila ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Symphysis Pubis
The pubic symphysis (: symphyses) is a secondary cartilaginous joint between the left and right superior rami of the pubis of the hip bones. It is in front of and below the urinary bladder. In males, the suspensory ligament of the penis attaches to the pubic symphysis. In females, the pubic symphysis is attached to the suspensory ligament of the clitoris. In most adults, it can be moved roughly 2 mm and with 1 degree rotation. This increases for women at the time of childbirth. The name comes from the Greek word ''symphysis'', meaning 'growing together'. Structure The pubic symphysis is a nonsynovial amphiarthrodial joint. The width of the pubic symphysis at the front is 3–5 mm greater than its width at the back. This joint is connected by fibrocartilage and may contain a fluid-filled cavity; the center is avascular, possibly due to the nature of the compressive forces passing through this joint, which may lead to harmful vascular disease. The ends of both pubic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Meniscus (anatomy)
A meniscus (: menisci or meniscuses) is a crescent-shaped fibrocartilage, fibrocartilaginous anatomy, anatomical structure that, in contrast to an articular disc, only partly divides a synovial joint#Structure, joint cavity.Platzer (2004), p 208 In humans, they are present in the knee, wrist, acromioclavicular joint, acromioclavicular, sternoclavicular joint, sternoclavicular, and temporomandibular joints; in other animals they may be present in other joints. Generally, the term "meniscus" is used to refer to the cartilage of the knee, either to the lateral meniscus, lateral or medial meniscus. Both are Cartilaginous#Fibrocartilage, cartilaginous tissues that provide structural integrity to the knee when it undergoes tension (mechanics), tension and torsion (mechanics), torsion. The menisci are also known as "semi-lunar" cartilages, referring to their half-moon, crescent shape. The term "meniscus" is from the Ancient Greek word (), meaning "crescent". Structure The menisci of t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Symphysis
A symphysis (, : symphyses) is a fibrocartilaginous fusion between two bones. It is a type of cartilaginous joint, specifically a secondary cartilaginous joint. # A symphysis is an amphiarthrosis, a slightly movable joint. # A growing together of parts or structures. Unlike synchondroses, symphyses are permanent. Examples The more prominent symphyses are: * the pubic symphysis * sacrococcygeal symphysis * intervertebral disc between two vertebrae * in the sternum, between the manubrium and body * mandibular symphysis In human anatomy, the facial skeleton of the skull the external surface of the mandible is marked in the median line by a faint ridge, indicating the mandibular symphysis (Latin: ''symphysis menti'') or line of junction where the two lateral ha ..., in the jaw Symphysis disorders Pubic symphysis diastasis Pubic symphysis diastasis is an extremely rare complication that occurs in women who are giving birth. Separation of the two pubic bones during deli ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetabular Labrum
The acetabular labrum (glenoidal labrum of the hip joint or cotyloid ligament in older texts) is a fibrocartilaginous ring which surrounds the circumference of the acetabulum of the hip, deepening the acetabulum. The labrum is attached onto the bony rim and transverse acetabular ligament. It is triangular in cross-section (with the apex represented by the free margin). The labrum contributes to the articular surface of the joint (increasing it by almost 10%). It embraces the femoral head, holding it firmly in the joint socket to stabilise the joint. It thus also seals the joint cavity, facilitating even distribution of synovial fluid Synovial fluid, also called synovia, elp 1/sup> is a viscous, non-Newtonian fluid found in the cavities of synovial joints. With its egg white–like consistency, the principal role of synovial fluid is to reduce friction between the articul ... so that friction is reduced and dissolved nutrients are better distributed. The labrum is about 2 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glenoid Labrum
The glenoid labrum (glenoid ligament) is a fibrocartilaginous (but not fibrocartilage, as previously thought) structure attached around the rim of the glenoid cavity on the shoulder blade. The shoulder joint is considered a ball-and-socket joint. However, in bony terms the 'socket' (the Glenoid cavity, glenoid fossa of the scapula) is quite shallow and small, covering at most only a third of the 'ball' (the Humerus, head of the humerus). The socket is deepened by the glenoid labrum, stabilizing the shoulder joint. The labrum is triangular in section; the base is fixed to the circumference of the cavity, while the free edge is thin and sharp. It is continuous above with the tendon of the long head of the biceps brachii, which gives off two muscle fascicle, fascicles to blend with the fibrous tissue of the labrum. Structure Clinical significance Injury Tearing of the labrum can occur from either Major trauma, acute trauma or repetitive shoulder motion such as in the sports of s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intervertebral Disc
An intervertebral disc (British English), also spelled intervertebral disk (American English), lies between adjacent vertebrae in the vertebral column. Each disc forms a fibrocartilaginous joint (a symphysis), to allow slight movement of the vertebrae, to act as a ligament to hold the vertebrae together, and to function as a shock absorber for the spine. Structure Intervertebral discs consist of an outer fibrous ring, the ''anulus (or annulus) fibrosus disci intervertebralis'', which surrounds an inner gel-like center, the ''nucleus pulposus''. The ''anulus fibrosus'' consists of several layers (laminae) of fibrocartilage made up of both type I and type II collagen. Type I is concentrated toward the edge of the ring, where it provides greater strength. The stiff laminae can withstand compressive forces. The fibrous intervertebral disc contains the ''nucleus pulposus'' and this helps to distribute pressure evenly across the disc. This prevents the development of stress conc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Extracellular Matrix
In biology, the extracellular matrix (ECM), also called intercellular matrix (ICM), is a network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM. The animal extracellular matrix includes the interstitial matrix and the basement membrane. Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). Gels of polysaccharides and fibrous proteins fill the interstitial space and act as a compression buffer against the stress placed on the ECM. Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest. Each type of connective tissue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chondrocyte
Chondrocytes (, ) are the only cells found in healthy cartilage. They produce and maintain the cartilaginous matrix, which consists mainly of collagen and proteoglycans. Although the word '' chondroblast'' is commonly used to describe an immature chondrocyte, the term is imprecise, since the progenitor of chondrocytes (which are mesenchymal stem cells) can differentiate into various cell types, including osteoblasts. Development From least- to terminally-differentiated, the chondrocytic lineage is: # Colony-forming unit-fibroblast # Mesenchymal stem cell / marrow stromal cell # Chondrocyte # Hypertrophic chondrocyte Mesenchymal (mesoderm origin) stem cells are undifferentiated, meaning they can differentiate into a variety of generative cells commonly known as osteochondrogenic (or osteogenic, chondrogenic, osteoprogenitor, etc.) cells. When referring to bone, or in this case cartilage, the originally undifferentiated mesenchymal stem cells lose their pluripotency, proliferate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Type II Collagen
Type II collagen is the basis for hyaline cartilage, including the articular cartilages at joint surfaces. It is formed by homotrimers of collagen, type II, alpha 1 chains. It makes up 50% of all protein in cartilage and 85–90% of collagen of articular cartilage. Type II collagen is organised into fibrils. This fibrillar network of collagen allows the cartilage to entrap the proteoglycan aggregate, as well as providing tensile strength to the tissue. Oral administration of native type II collagen induces oral tolerance to pathological immune responses and the administration of type II collagen tablets together with paracetamol might be more effective at reducing symptoms of osteoarthritis than paracetamol by itself. See also * Type I collagen Type I collagen is the most abundant collagen of the human body, consisting of around 90% of the body's total collagen in vertebrates. Due to this, it is also the most abundant protein type found in all vertebrates. Type I form ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Type I Collagen
Type I collagen is the most abundant collagen of the human body, consisting of around 90% of the body's total collagen in vertebrates. Due to this, it is also the most abundant protein type found in all vertebrates. Type I forms large, eosinophilic fibers known as collagen fibers, which make up most of the rope-like dense connective tissue in the body. Collagen I itself is created by the combination of both a proalpha1 and a proalpha2 chain created by the COL1alpha1 and COL1alpha2 genes respectively. The Col I gene itself takes up a triple-helical conformation due to its Glycine-X-Y structure, x and y being any type of amino acid. Collagen can also be found in two different isoforms, either as a homotrimer or a heterotrimer, both of which can be found during different periods of development. Heterotrimers, in particular, play an important role in wound healing, and are the dominant isoform found in the body. Type I collagen can be found in a myriad of different places in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
