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Fesoterodine
Fesoterodine (International Nonproprietary Name, INN, used as the fumarate under the brand name Toviaz) is an antimuscarinic drug developed by Schwarz Pharma AG to treat overactive bladder, overactive bladder syndrome (OAB). It was approved by the European Medicines Agency in April 2007, the US Food and Drug Administration on October 31, 2008 and Health Canada on February 9, 2012. Fesoterodine is a prodrug. It is broken down into its active metabolite, desfesoterodine, by plasma esterases. Efficacy Fesoterodine has the advantage of allowing more flexible dosage than other muscarinic antagonists. Its tolerability and side effects are similar to other muscarinic antagonists and as a new drug seems unlikely to make great changes in practices of treatment for overactive bladder. A Japanese study from 2017, showed that urgency and urge incontinence are improved after 3 days administration of the drug, with full efficacy able to be judged after 7 days administration. Overactive blad ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Desfesoterodine
Desfesoterodine (International Nonproprietary Name, INN, also called 5-hydroxymethyltolterodine) is an antimuscarinic drug. It is the active metabolite of fesoterodine, its Isobutyric acid, isobutyrate ester. References Muscarinic antagonists Primary alcohols Phenols Diisopropylamino compounds {{genito-urinary-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prodrug
A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. Instead of administering a drug directly, a corresponding prodrug can be used to improve how the drug is absorbed, distributed, metabolized, and excreted (ADME). Prodrugs are often designed to improve bioavailability when a drug itself is poorly absorbed from the gastrointestinal tract. A prodrug may be used to improve how selectively the drug interacts with cells or processes that are not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. History Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, sal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Schwarz Pharma AG
UCB (Union Chimique Belge) is a multinational biopharmaceutical company headquartered in Brussels, Belgium. UCB is an international company with revenue of €4.178 billion in 2016 which focuses primarily on research and development, specifically involving medications centered on epilepsy, Parkinson's disease, and Crohn's disease. The company's efforts are focused on treatments for severe diseases treated by specialists, particularly in the fields of central nervous system (CNS) disorders (including epilepsy), inflammatory disorders (including allergy), and oncology. Every three years, the company presents the UCB Award under the patronage of the Queen Elisabeth Medical Foundation to promote neuroscience research. The winner of this award is selected by an independent scientific committee. History UCB was founded on 18 January 1928 by Emmanuel Janssen, a Belgian businessman. Initially focused on industrial chemicals (it was one of the first companies to distill ammonia fro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Overactive Bladder
Overactive bladder (OAB) is a common condition where there is a frequent feeling of needing to urinate to a degree that it negatively affects a person's life. The frequent need to urinate may occur during the day, at night, or both. Loss of bladder control (urge incontinence) may occur with this condition. This condition is also sometimes characterized by a sudden and involuntary contraction of the bladder muscles, in response to excitement or anticipation. This in turn leads to a frequent and urgent need to urinate. Overactive bladder affects approximately 11% of the population and more than 40% of people with overactive bladder have incontinence. Conversely, about 40% to 70% of urinary incontinence is due to overactive bladder. Overactive bladder is not life-threatening, but most people with the condition have problems for years. The cause of overactive bladder is unknown. Risk factors include obesity, caffeine, and constipation. Poorly controlled diabetes, poor function ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenol Esters
Phenol (also known as carbolic acid, phenolic acid, or benzenol) is an aromatic organic compound with the molecular formula . It is a white crystalline solid that is volatile and can catch fire. The molecule consists of a phenyl group () bonded to a hydroxy group (). Mildly acidic, it requires careful handling because it can cause chemical burns. It is acutely toxic and is considered a health hazard. Phenol was first extracted from coal tar, but today is produced on a large scale (about 7 million tonnes a year) from petroleum-derived feedstocks. It is an important industrial commodity as a precursor to many materials and useful compounds, and is a liquid when manufactured. It is primarily used to synthesize plastics and related materials. Phenol and its chemical derivatives are essential for production of polycarbonates, epoxies, explosives such as picric acid, Bakelite, nylon, detergents, herbicides such as phenoxy herbicides, and numerous pharmaceutical drugs. Propertie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
M5 Receptor Antagonists
M5, M-5, M.5, M-V, or M05 may refer to: Transportation Automobiles * AITO M5, a Chinese mid-size crossover SUV * BMW M5, a German mid-size performance car series * Dongfeng Fengxing Lingzhi M5, a Chinese MPV * Haima M5, a Chinese compact sedan * JAC Refine M5, a Chinese MPV * Studebaker M5, an American pickup truck Aviation and aerospace * M-5 rocket, a Japanese rocket * Macchi M.5, an Italian flying boat fighter in service from 1917 until the mid-1920s * Miles M.5 Sparrowhawk, a 1930s British single-seat racing and touring monoplane * Fokker M.5, a 1913 unarmed single-seat monoplane aircraft * Grigorovich M-5, a Russian World War I-era biplane flying boat * Kenmore Air (IATA airline designator: M5), a small airline based in the United States Military * M5 Stuart, a variant of the Stuart tank, a World War II-era American light tank * M5 half-track, a variant of the M3 Half-track military armored personnel carrier * M5 tractor, World War II-era artillery-towing tractor * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
M4 Receptor Antagonists
M4 or M-4 most often refers to: * M4 carbine, an American carbine * M4 Sherman, an American World War II medium tank M4, M04, or M-4 may also refer to: Arts and entertainment * ''M4'' (EP), a 2006 EP by Faunts * ''M4'' (video game), a 1992 computer game developed for the Macintosh * ''M.IV'' ("Matrix IV"), the fictional Warner Brothers videogame project inside the 2021 film '' The Matrix Resurrections'' * Former name of band First to Eleven * M4, the robot assistant to the character Flint in the Star Trek episode Requiem for Methuselah Military Weapons * Benelli M4 Super 90, an Italian semi-automatic,gas-operated shotgun * M4 autocannon, an American 37 mm automatic gun * M4 Selectable Lightweight Attack Munition (SLAM), an American land mine * M4 SLBM, a French submarine-launched ballistic missile from 1985 * M4 Survival Rifle, an American rifle in aircraft survival gear * Spectre M4, an Italian submachine gun * M4 bayonet, an American World War II bayon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
M3 Receptor Antagonists
M3, M-3 or M03 may refer to: Computing and electronics * Apple M3, a central processing unit in the Apple M series * Intel m3, a brand of microprocessors * M.3 (aka NF1/NGSFF), a specification for internally mounted expansion cards * Leica M3, a landmark 35mm rangefinder camera * Modula-3 (M3), a programming language * M3, a British peak programme meter standard used for measuring the volume of audio broadcasts * m3, a macro processor for the AP-3 minicomputer, the predecessor to m4 * M3, a surface-mount version of the 1N4003 general-purpose silicon rectifier diode * M3 (email client), an unreleased email client for the Vivaldi browser Entertainment * M3, a comic book created by Vicente Alcazar * M3 adapter, a Game Boy Advance movie player * M3 (Canadian TV channel), a music and entertainment television channel * M3 (Hungarian TV channel), a Hungarian television channel * '' M3: Malay Mo Ma-develop'', a 2010 Philippine TV series * M3 Music Card, a 2007 flash-based MP ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
M2 Receptor Antagonists
M, or m, is the thirteenth letter of the Latin alphabet, used in the modern English alphabet, the alphabets of several western European languages and others worldwide. Its name in English is ''em'' (pronounced ), plural ''ems''. History The letter M is derived from the Phoenician Mem via the Greek Mu (Μ, μ). Semitic Mem is most likely derived from a " Proto-Sinaitic" (Bronze Age) adoption of the "water" ideogram in Egyptian writing. The Egyptian sign had the acrophonic value , from the Egyptian word for "water", ''nt''; the adoption as the Semitic letter for was presumably also on acrophonic grounds, from the Semitic word for "water", '' *mā(y)-''. Use in writing systems English In English, represents the voiced bilabial nasal . The Oxford English Dictionary (first edition) says that is sometimes a vowel, such as in words like ''spasm'' and in the suffix ''-ism''. In modern terminology, this is described as a syllabic consonant (IPA: ). M is the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
M1 Receptor Antagonists
M1, M01 or M-1 may refer to: Arts, entertainment & media * M-1 (rapper), one half of hip hop duo Dead Prez * Korg M1, a keyboard synthesizer * Leica M1, a 1959 35 mm camera model * Olympus OM-1, a 1972 manually operated 35mm single-lens reflex camera * M1 (TV channel), news channel of the Hungarian MTVA * M-1 (Lithuanian radio station) * M1 (Ukraine), a television channel * M1 (Russian TV channel) Economics and finance * M1 (money supply measure), in economics, a measure of the money supply * M1 Finance, an online financial services company Military equipment Vehicles US Armed Forces * M1 Abrams, a main battle tank * M1 armored car * M1 combat car, an early tank * M1 light tractor * M1 medium tractor * M1 heavy tractor Other * Bristol M.1, a 1916 British fighter aircraft * (M1), a WWI Royal Navy monitor * (1919), an early British submarine * , a Swedish Navy mine sweeper * , a Swedish Royal Navy mine layer Weapons US Armed Forces * 120 mm gun M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drugs Developed By Pfizer
A drug is any chemical substance other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect. Consumption of drugs can be via inhalation, injection, smoking, ingestion, absorption via a patch on the skin, suppository, or dissolution under the tongue. In pharmacology, a drug is a chemical substance, typically of known structure, which, when administered to a living organism, produces a biological effect. A pharmaceutical drug, also called a medication or medicine, is a chemical substance used to treat, cure, prevent, or diagnose a disease or to promote well-being. Traditionally drugs were obtained through extraction from medicinal plants, but more recently also by organic synthesis. Pharmaceutical drugs may be used for a limited duration, or on a regular basis for chronic disorders. Classification Pharmaceutical drugs are often classified into drug classes—groups of related drugs that have sim ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
