HOME



picture info

Feline Immunodeficiency Virus
Feline immunodeficiency virus (FIV) is a lentivirus that affects cats worldwide and 2.5% to 4.4% of felines are infected. FIV was first isolated in 1986, by Niels C. Pedersen and Janet K. Yamamoto at the UC Davis School of Veterinary Medicine in a colony of cats that had a high prevalence of opportunistic infections and degenerative conditions, and was originally called ''feline T-lymphotropic virus''. It has since been identified in domestic cats. Effects FIV compromises the immune system of cats by infecting many cell types, including CD4+ and CD8+ T lymphocytes, B lymphocytes, and macrophages. FIV can be tolerated well by cats, but can eventually lead to debilitation of the immune system in its feline hosts by the infection and exhaustion of T-helper (CD4+) cells. FIV and HIV are both lentiviruses. However, humans cannot be infected by FIV, nor can cats be infected by HIV. FIV is transmitted primarily through deep bite wounds, where the virus present in the in ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]  


picture info

Feline Infectious Peritonitis
Feline infectious peritonitis (FIP) is a common and aberrant immune response in cats to infection with feline coronavirus (FCoV). The virus and pathogenesis of FIP FCoV is a virus of the gastrointestinal tract. Most infections are either asymptomatic or cause diarrhea, especially in kittens, as maternally derived antibody wanes at between 5 and 7 weeks of age. The virus is a mutation of feline enteric coronavirus (FECV). From the gut, the virus very briefly undergoes a Systemic disease, systemic phase, before returning to the gut where it is shed in the feces. The pathogenesis of FIP is complex. There is a general consensus that FIPVs arise from mutations enabling them to enter or replicate more successfully in monocytes (a type of white blood cell). However, many aspects of virus–host interactions affecting the disease remain uncertain, such as the factors that influence disease form (wet or dry), outcome (death or resistance), and host susceptibility. Virus and disease tr ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]  


picture info

Secondary Infection
infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable disease, is an illness resulting from an infection. Infections can be caused by a wide range of pathogens, most prominently bacteria and viruses. Hosts can fight infections using their immune systems. Mammalian hosts react to infections with an innate response, often involving inflammation, followed by an adaptive response. Treatment for infections depends on the type of pathogen involved. Common medications include: * Antibiotics for bacterial infections. * Antivirals for viral infections. * Antifungals for fungal infections. * Antiprotozoals for protozoan infections. * Antihelminthics for infections caused by parasitic worms. Infectious diseases remain a significant global health concern, causing approximately 9.2 million deaths ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]  


picture info

Glycoprotein
Glycoproteins are proteins which contain oligosaccharide (sugar) chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. Secreted extracellular proteins are often glycosylated. In proteins that have segments extending extracellularly, the extracellular segments are also often glycosylated. Glycoproteins are also often important integral membrane proteins, where they play a role in cell–cell interactions. It is important to distinguish endoplasmic reticulum-based glycosylation of the secretory system from reversible cytosolic-nuclear glycosylation. Glycoproteins of the cytosol and nucleus can be modified through the reversible addition of a single GlcNAc residue that is considered reciprocal to phosphorylation and the functions of these are likely to be an additional regulatory mechanism that controls phosphorylation-based signalling. In ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]  


picture info

Feral Cat
A feral cat or a stray cat is an unowned domestic cat (''Felis catus'') that lives outdoors and avoids human contact; it does not allow itself to be handled or touched, and usually remains hidden from humans. Feral cats may breed over dozens of generations and become a local apex predator in urban, savannah and bushland environments, and especially on islands where native animals did not evolve alongside predators. Some feral cats may become more comfortable with people who regularly feed them, but even with long-term attempts at socialization of animals, socialization, they usually remain aloof and reject human touch. Of the 700 million cats in the world, an estimated 480 million are feral. Feral cats are devastating to wildlife, and conservation biologists consider them to be one of the worst invasive species on Earth. They are included in the list of 100 of the World's Worst Invasive Alien Species, the world's 100 worst invasive alien species. Attempts to control feral cat ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]  




American Association Of Feline Practitioners
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label that was previously known as Def American * American University, in Washington, D.C. Sports teams S ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]  


picture info

Animal Euthanasia
Animal euthanasia (euthanasia from ; "good death") is the act of killing an animal humanely, most commonly with injectable drugs. Reasons for euthanasia include incurable (and especially painful) conditions or diseases, lack of resources to continue supporting the animal, or laboratory test procedures. Euthanasia methods are designed to cause minimal pain and distress. Euthanasia is distinct from animal slaughter and pest control. In domesticated animals, the discussion of animal euthanasia may be substituted with euphemisms, such as "put down" or "put to sleep" to make the wording less harsh. Methods The methods of euthanasia can be divided into pharmacological and physical methods. Acceptable pharmacological methods include injected drugs and gases that first depress the central nervous system and then cardiovascular activity. Acceptable physical methods must first cause rapid loss of consciousness by disrupting the central nervous system. The most common methods are discus ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]  


Viral Infectivity Factor
Viral infectivity factor, or Vif, is an accessory protein found in HIV and other lentiviruses. Its role is to disrupt the antiviral activity of the human enzyme APOBEC (specifically APOBEC3G, "A3G" in short, and other A3 enzymes) by targeting it for ubiquitination and cellular degradation. APOBEC is a cytidine deaminase enzyme that mutates viral nucleic acids. Despite the functional and (weak) structural similarities, Vif found in lentiviruses can function in quite different ways. For example, the HIV-1 Vif ("Vif1" hereafter) and HIV-2 Vif ("Vif2") attach to APOBEC from different ends of themselves and have a different spectrum of inhibition. As HIV-1 is older and more virulent, many more studies have been done on the Vif1 than on the Vif2. Similarly, more studies have been done on the HIV/ SIV Vif than on any other lentiviral Vif. Mechanism HIV-1 Vif1 is a 23-kilodalton protein that is essential for viral replication. Vif1 inhibits the cellular protein APOBEC3G from enteri ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]  


picture info

APOBEC3
APOBEC3G (apolipoprotein B mRNA editing enzyme, catalytic subunit 3G) is a human enzyme encoded by the ''APOBEC3G'' gene that belongs to the APOBEC superfamily of proteins. This family of proteins has been suggested to play an important role in innate anti-viral immunity. APOBEC3G belongs to the family of cytidine deaminases that catalyze the deamination of cytidine to uridine in the single stranded DNA substrate. The C-terminal domain of A3G renders catalytic activity, several NMR and crystal structures explain the substrate specificity and catalytic activity. APOBEC3G exerts innate antiretroviral immune activity against retroviruses, most notably HIV, by interfering with proper replication. However, lentiviruses such as HIV have evolved the Viral infectivity factor (Vif) protein in order to counteract this effect. Vif interacts with APOBEC3G and triggers the ubiquitination and degradation of APOBEC3G via the proteasomal pathway. On the other hand, foamy viruses produce an acc ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]  


Puma (genus)
''Puma'' ( or ) is a genus in the family Felidae whose only extant species is the cougar (also known as the puma, mountain lion, and panther, among other names), and may also include several poorly known Old World fossil representatives (for example, '' Puma pardoides'', or Owen's panther, a large, cougar-like cat of Eurasia's Pliocene). In addition to these potential Old World fossils, a few New World fossil representatives are possible, such as '' Puma pumoides'' and the two species of the so-called " American cheetah", currently classified under the genus ''Miracinonyx''. Description Pumas are large, secretive cats. They are also commonly known as cougars and mountain lions, and are able to reach larger sizes than some other "big" cat individuals. Despite their large size, they are more closely related to smaller feline species than to lions or leopards. The two subspecies of pumas have similar characteristics but tend to vary in color and size. Pumas are the most adaptable fe ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]  


picture info

Clade
In biology, a clade (), also known as a Monophyly, monophyletic group or natural group, is a group of organisms that is composed of a common ancestor and all of its descendants. Clades are the fundamental unit of cladistics, a modern approach to taxonomy adopted by most biological fields. The common ancestor may be an individual, a population, or a species (extinct or Extant taxon, extant). Clades are nested, one in another, as each branch in turn splits into smaller branches. These splits reflect evolutionary history as populations diverged and evolved independently. Clades are termed ''monophyletic'' (Greek: "one clan") groups. Over the last few decades, the cladistic approach has revolutionized biological classification and revealed surprising evolutionary relationships among organisms. Increasingly, taxonomists try to avoid naming Taxon, taxa that are not clades; that is, taxa that are not Monophyly, monophyletic. Some of the relationships between organisms that the molecul ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]  


picture info

Lion
The lion (''Panthera leo'') is a large Felidae, cat of the genus ''Panthera'', native to Sub-Saharan Africa and India. It has a muscular, broad-chested body (biology), body; a short, rounded head; round ears; and a dark, hairy tuft at the tip of its tail. It is sexually dimorphic; adult male lions are larger than females and have a prominent mane. It is a social species, forming groups called prides. A lion's pride consists of a few adult males, related females, and cubs. Groups of female lions usually hunt together, preying mostly on medium-sized and large ungulates. The lion is an apex predator, apex and keystone predator. The lion inhabits grasslands, savannahs, and shrublands. It is usually more diurnality, diurnal than other wild cats, but when persecuted, it adapts to being active nocturnality, at night and crepuscular, at twilight. During the Neolithic period, the lion ranged throughout Africa and Eurasia, from Southeast Europe to India, but it has been reduced to fr ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]  


picture info

Wildcat
The wildcat is a species complex comprising two small wild cat species: the European wildcat (''Felis silvestris'') and the African wildcat (''F. lybica''). The European wildcat inhabits forests in Europe, Anatolia and the Caucasus, while the African wildcat inhabits semi- arid landscapes and steppes in Africa, the Arabian Peninsula, Central Asia, into western India and western China. The wildcat species differ in fur pattern, tail, and size: the European wildcat has long fur and a bushy tail with a rounded tip; the smaller African wildcat is more faintly striped, has short sandy-gray fur and a tapering tail; the Asiatic wildcat (''F. lybica ornata'') is spotted. The wildcat and the other members of the cat family had a common ancestor about 10–15 million years ago. The European wildcat evolved during the Cromerian Stage about 866,000 to 478,000 years ago; its direct ancestor was '' Felis lunensis''. The ''silvestris'' and ''lybica'' lineages probably diverged about 173 ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]