|
Entorhinal
The entorhinal cortex (EC) is an area of the brain's allocortex, located in the medial temporal lobe, whose functions include being a widespread network hub for memory, navigation, and the perception of time.Integrating time from experience in the lateral entorhinal cortex Albert Tsao, Jørgen Sugar, Li Lu, Cheng Wang, James J. Knierim, May-Britt Moser & Edvard I. Moser Naturevolume 561, pages57–62 (2018) The EC is the main interface between the hippocampus and neocortex. The EC-hippocampus system plays an important role in declarative (autobiographical/episodic/semantic) memories and in particular spatial memories including memory formation, memory consolidation, and memory optimization in sleep. The EC is also responsible for the pre-processing (familiarity) of the input signals in the reflex nictitating membrane response of classical trace conditioning; the association of impulses from the eye and the ear occurs in the entorhinal cortex. Anatomy The entorhinal co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Grid Cells
A grid cell is a type of neuron within the entorhinal cortex that fires at regular intervals as an animal navigates an open area, allowing it to understand its position in space by storing and integrating information about location, distance, and direction. Grid cells have been found in many animals, including rats, mice, bats, monkeys, and humans. Grid cells were discovered in 2005 by Edvard Moser, May-Britt Moser, and their students Torkel Hafting, Marianne Fyhn, and Sturla Molden at the Centre for the Biology of Memory (CBM) in Norway. They were awarded the 2014 Nobel Prize in Physiology or Medicine together with John O'Keefe for their discoveries of cells that constitute a positioning system in the brain. The arrangement of spatial firing fields, all at equal distances from their neighbors, led to a hypothesis that these cells encode a neural representation of Euclidean space. The discovery also suggested a mechanism for dynamic computation of self-position based on continu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hippocampus
The hippocampus (: hippocampi; via Latin from Ancient Greek, Greek , 'seahorse'), also hippocampus proper, is a major component of the brain of humans and many other vertebrates. In the human brain the hippocampus, the dentate gyrus, and the subiculum are components of the hippocampal formation located in the limbic system. The hippocampus plays important roles in the Memory consolidation, consolidation of information from short-term memory to long-term memory, and in spatial memory that enables Navigation#Navigation in spatial cognition, navigation. In humans, and other primates the hippocampus is located in the archicortex, one of the three regions of allocortex, in each cerebral hemisphere, hemisphere with direct neural projections to, and reciprocal indirect projections from the neocortex. The hippocampus, as the medial pallium, is a structure found in all vertebrates. In Alzheimer's disease (and other forms of dementia), the hippocampus is one of the first regions of th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spatial Memory
In cognitive psychology and neuroscience, spatial memory is a form of memory responsible for the recording and recovery of information needed to plan a course to a location and to recall the location of an object or the occurrence of an event. Spatial memory is necessary for orientation in space. Spatial memory can also be divided into egocentric and allocentric spatial memory. A person's spatial memory is required to navigate in a familiar city. A rat's spatial memory is needed to learn the location of food at the end of a maze. In both humans and animals, spatial memories are summarized as a cognitive map. Spatial memory has representations within working, short-term memory and long-term memory. Research indicates that there are specific areas of the brain associated with spatial memory. Many methods are used for measuring spatial memory in children, adults, and animals. Short-term spatial memory Short-term memory (STM) can be described as a system allowing one to temporarily ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cognitive Map
A cognitive map is a type of mental representation used by an individual to order their personal store of information about their everyday or metaphorical spatial environment, and the relationship of its component parts. The concept was introduced by Edward Tolman in 1948. He tried to explain the behavior of rats that appeared to learn the spatial layout of a maze, and subsequently the concept was applied to other animals, including humans. The term was later generalized by some researchers, especially in the field of operations research, to refer to a kind of semantic network representing an individual's personal knowledge or schemas. Overview Cognitive maps have been studied in various fields, such as psychology, education, archaeology, planning, geography, cartography, architecture, landscape architecture, urban planning, management and history. Because of the broad use and study of cognitive maps, it has become a colloquialism for almost any mental representation or model ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Subiculum
The subiculum (Latin for "support") also known as the subicular complex, or subicular cortex, is the most inferior component of the hippocampal formation. It lies between the entorhinal cortex and the CA1 hippocampal subfield. The subicular complex comprises a set of four related structures including the prosubiculum, presubiculum, postsubiculum and parasubiculum. Name The subiculum got its name from Karl Friedrich Burdach in his three-volume work ''Vom Bau und Leben des Gehirns'' (Vol. 2, §199). He originally named it subiculum cornu ammonis and so associated it with the rest of the hippocampal subfields. Structure The subicular complex receives input from CA1 and entorhinal cortical layer III pyramidal neurons and is the main output of the hippocampus proper. The pyramidal neurons send projections to the nucleus accumbens, septal nuclei, prefrontal cortex, lateral hypothalamus, nucleus reuniens, mammillary nuclei, entorhinal cortex and amygdala. The pyramidal neuro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brodmann Area 34
Brodmann area 34 is a region of the brain. It has been described as part of the entorhinal area and the superior temporal gyrus. The entorhinal area is the main interface between the hippocampus and neocortex and involved in memory, navigation and the perception of time. Destruction of Brodmann area 34 results in ipsilateral anosmia Anosmia, also known as smell blindness, is the lack of ability to detect one or more smells. Anosmia may be temporary or permanent. It differs from hyposmia, which is a decreased sensitivity to some or all smells. Anosmia can be categorized int .... See also * Brodmann area References 34 Olfactory system Temporal lobe Medial surface of cerebral hemisphere {{Neuroanatomy-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dentate Gyrus
The dentate gyrus (DG) is one of the subfields of the hippocampus, in the hippocampal formation. The hippocampal formation is located in the temporal lobe of the brain, and includes the hippocampus (including CA1 to CA4) subfields, and other subfields including the dentate gyrus, subiculum, and presubiculum. The dentate gyrus is part of the trisynaptic circuit, a neural circuit of the hippocampus, thought to contribute to the formation of new episodic memories, the spontaneous exploration of novel environments and other functions. The dentate gyrus has toothlike projections from which it is named. The subgranular zone of the dentate gyrus is one of only two major sites of adult neurogenesis in the brain, and is found in many mammals. The other main site is the subventricular zone in the ventricular system. Other sites may include the striatum and the cerebellum. However, whether significant neurogenesis takes place in the adult human dentate gyrus has been a matter of d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brodmann Area 28
Brodmann area 28 is a subdivision of the cerebral cortex defined on the basis of cytoarchitecture. It is located on the medial aspect of the temporal lobe and is part of the entorhinal cortex Human In humans, Brodmann area 28, and Brodmann area 34 together constitute approximately the entorhinal cortex. Guenon Brodmann regarded the location of area 28 adjacent to the hippocampus as imprecisely represented in the illustration of the cortex of the guenon brain in Brodmann-1909. It is located on the medial aspect of the temporal lobe. Distinctive features The molecular layer (I) is unusually wide; the external granular layer (II) contains nests of, for the most part, multipolar cells: the external pyramidal layer (III) contains medium-sized pyramidal cells which merge with cells of the internal pyramidal layer (V); a clear cell free zone represents sublayer 5b of layer V; the multiform layer is wide and has a less clear two sublayer structure; the internal granular layer (I ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EC-hippocampus System
The entorhinal cortex (EC) is a major part of the hippocampal formation of the brain, and is reciprocally connected with the hippocampus. The hippocampal formation, which consists of the hippocampus, perirhinal cortex, the dentate gyrus, the subicular areas and the EC forms one of the most important parts of the limbic system. The entorhinal cortex is an infolding of the parahippocampal gyrus into the inferior (temporal) horn of the lateral ventricle. Role in knowledge processing and memory Studies, with human patients and with experimental animals, suggest that knowledge stored as explicit memory is first acquired through processing in one or more of the three polymodal association cortices (prefrontal, limbic, and parieto-occipital-temporal) to form visual, auditory and somatic information. From there, the information is then conveyed in series to the parahippocampal and perirhinal cortices, then onwards to the EC, dentate gyrus, hippocampus, subiculum and then finally back to t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Perirhinal Cortex
The perirhinal cortex is a brain cortex, cortical region in the medial temporal lobe that is made up of Brodmann areas Brodmann area 35, 35 and Brodmann area 36, 36. It receives highly processed sensory information from all sensory regions, and is generally accepted to be an important region for memory. It is bordered caudally by postrhinal cortex or parahippocampal gyrus, parahippocampal cortex (homologous regions in rodents and primates, respectively) and ventrally and Anatomical terms of location#Left and right (lateral), and medial, medially by entorhinal cortex. Structure The perirhinal cortex is composed of two regions: areas 36 and 35. Area 36 is sometimes divided into three subdivisions: 36d is the most rostral and dorsal, 36r ventral and caudal, and 36c the most caudal. Area 35 can be divided in the same manner, into 35d and 35v (for dorsal and ventral, respectively). Area 36 is six-layered, dysgranular, meaning that its layer IV is relatively sparse. Area 35 is agran ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reelin
Reelin, encoded by the ''RELN'' gene, is a large secreted extracellular matrix glycoprotein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this important role in early Developmental biology, development, reelin continues to work in the adult brain. It modulates synaptic plasticity by enhancing the induction and maintenance of long-term potentiation. It also stimulates dendrite and dendritic spine development in the hippocampus, and regulates the continuing migration of neuroblasts generated in adult neurogenesis sites of the subventricular zone, subventricular and subgranular zones. It is found not only in the brain but also in the liver, Thyroid, thyroid gland, adrenal gland, fallopian tube, breast and in comparatively lower levels across a range of anatomical regions. Reelin has been suggested to be implicated in pathogenesis of several brain diseases. The expression of the protein has ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Memory
Memory is the faculty of the mind by which data or information is encoded, stored, and retrieved when needed. It is the retention of information over time for the purpose of influencing future action. If past events could not be remembered, it would be impossible for language, relationships, or personal identity to develop. Memory loss is usually described as forgetfulness or amnesia. Memory is often understood as an informational processing system with explicit and implicit functioning that is made up of a sensory processor, short-term (or working) memory, and long-term memory. This can be related to the neuron. The sensory processor allows information from the outside world to be sensed in the form of chemical and physical stimuli and attended to various levels of focus and intent. Working memory serves as an encoding and retrieval processor. Information in the form of stimuli is encoded in accordance with explicit or implicit functions by the working memory p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
