Carbon Ion Radiotherapy
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Carbon Ion Radiotherapy
Particle therapy is a form of external beam radiotherapy using beams of energetic neutrons, protons, or other heavier positive ions for cancer treatment. The most common type of particle therapy as of August 2021 is proton therapy. In contrast to X-rays (photon beams) used in older radiotherapy, particle beams exhibit a Bragg peak in energy loss through the body, delivering their maximum radiation dose at or near the tumor and minimizing damage to surrounding normal tissues. Particle therapy is also referred to more technically as hadron therapy, excluding photon and electron therapy. Neutron capture therapy, which depends on a secondary nuclear reaction, is also not considered here. Muon therapy, a rare type of particle therapy not within the categories above, has also been attempted however, muons are still most commonly used for imaging, rather than therapy. Method Particle therapy works by aiming energetic ionizing particles at the target tumor. These particles damage ...
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External Beam Radiotherapy
External beam radiotherapy (EBRT) is the most common form of radiotherapy (radiation therapy). The patient sits or lies on a couch and an external source of ionizing radiation is pointed at a particular part of the body. In contrast to brachytherapy (sealed source radiotherapy) and unsealed source radiotherapy, in which the radiation source is inside the body, external beam radiotherapy directs the radiation at the tumour from outside the body. Orthovoltage ("superficial") X-rays are used for treating skin cancer and superficial structures. Megavoltage X-rays are used to treat deep-seated tumours (e.g. bladder, bowel, prostate, lung, or brain), whereas megavoltage electron beams are typically used to treat superficial lesions extending to a depth of approximately 5 cm (increasing beam energy corresponds to greater penetration). X-rays and electron beams are by far the most widely used sources for external beam radiotherapy. A small number of centers operate experimental and pi ...
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Stopping Power (particle Radiation)
In nuclear and materials physics, stopping power is the retarding force acting on charged particles, typically alpha and beta particles, due to interaction with matter, resulting in loss of particle kinetic energy. Its application is important in areas such as radiation protection, ion implantation and nuclear medicine.ICRU Report 73: Stopping of Ions heavier than Helium, Journal of the ICRU, 5 No. 1 (2005), Oxford Univ. Press Definition and Bragg curve Both charged and uncharged particles lose energy while passing through matter. Positive ions are considered in most cases below. The stopping power depends on the type and energy of the radiation and on the properties of the material it passes. Since the production of an ion pair (usually a positive ion and a (negative) electron) requires a fixed amount of energy (for example, 33.97 eV in dry air), the number of ionizations per path length is proportional to the stopping power. The ''stopping power'' of the material is numeri ...
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Radiation Therapy Procedures
In physics, radiation is the emission or transmission of energy in the form of waves or particles through space or through a material medium. This includes: * ''electromagnetic radiation'', such as radio waves, microwaves, infrared, visible light, ultraviolet, x-rays, and gamma radiation (γ) * ''particle radiation'', such as alpha radiation (α), beta radiation (β), proton radiation and neutron radiation (particles of non-zero rest energy) * '' acoustic radiation'', such as ultrasound, sound, and seismic waves (dependent on a physical transmission medium) * '' gravitational radiation'', that takes the form of gravitational waves, or ripples in the curvature of spacetime Radiation is often categorized as either ''ionizing'' or '' non-ionizing'' depending on the energy of the radiated particles. Ionizing radiation carries more than 10 eV, which is enough to ionize atoms and molecules and break chemical bonds. This is an important distinction due to the large differenc ...
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Carbon
Carbon () is a chemical element with the symbol C and atomic number 6. It is nonmetallic and tetravalent—its atom making four electrons available to form covalent chemical bonds. It belongs to group 14 of the periodic table. Carbon makes up only about 0.025 percent of Earth's crust. Three isotopes occur naturally, C and C being stable, while C is a radionuclide, decaying with a half-life of about 5,730 years. Carbon is one of the few elements known since antiquity. Carbon is the 15th most abundant element in the Earth's crust, and the fourth most abundant element in the universe by mass after hydrogen, helium, and oxygen. Carbon's abundance, its unique diversity of organic compounds, and its unusual ability to form polymers at the temperatures commonly encountered on Earth, enables this element to serve as a common element of all known life. It is the second most abundant element in the human body by mass (about 18.5%) after oxygen. The atoms of carbo ...
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Fermilab
Fermi National Accelerator Laboratory (Fermilab), located just outside Batavia, Illinois, near Chicago, is a United States Department of Energy national laboratory specializing in high-energy particle physics. Since 2007, Fermilab has been operated by the Fermi Research Alliance, a joint venture of the University of Chicago, and the Universities Research Association (URA). Fermilab is a part of the Illinois Technology and Research Corridor. Fermilab's Main Injector, two miles (3.3 km) in circumference, is the laboratory's most powerful particle accelerator. The accelerator complex that feeds the Main Injector is under upgrade, and construction of the first building for the new PIP-II linear accelerator began in 2020. Until 2011, Fermilab was the home of the 6.28 km (3.90 mi) circumference Tevatron accelerator. The ring-shaped tunnels of the Tevatron and the Main Injector are visible from the air and by satellite. Fermilab aims to become a world center in neut ...
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Beryllium
Beryllium is a chemical element with the symbol Be and atomic number 4. It is a steel-gray, strong, lightweight and brittle alkaline earth metal. It is a divalent element that occurs naturally only in combination with other elements to form minerals. Notable gemstones high in beryllium include beryl ( aquamarine, emerald) and chrysoberyl. It is a relatively rare element in the universe, usually occurring as a product of the spallation of larger atomic nuclei that have collided with cosmic rays. Within the cores of stars, beryllium is depleted as it is fused into heavier elements. Beryllium constitutes about 0.0004 percent by mass of Earth's crust. The world's annual beryllium production of 220 tons is usually manufactured by extraction from the mineral beryl, a difficult process because beryllium bonds strongly to oxygen. In structural applications, the combination of high flexural rigidity, thermal stability, thermal conductivity and low density (1.85 times that of water) ...
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Radiation Therapy
Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is a therapy using ionizing radiation, generally provided as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator. Radiation therapy may be curative in a number of types of cancer if they are localized to one area of the body. It may also be used as part of adjuvant therapy, to prevent tumor recurrence after surgery to remove a primary malignant tumor (for example, early stages of breast cancer). Radiation therapy is synergistic with chemotherapy, and has been used before, during, and after chemotherapy in susceptible cancers. The subspecialty of oncology concerned with radiotherapy is called radiation oncology. A physician who practices in this subspecialty is a radiation oncologist. Radiation therapy is commonly applied to the cancerous tumor because of its ability to control cell growth. Ionizing radiation works by damaging the DNA of cancerous tissue ...
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Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate cancer, they can also have other causes. Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor diet, lack of physical activity or excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. In the developing world, 15% of cancers are due to infections such as ''Helicobacter pylori'', hepatitis B, hepatitis C, human papillomavirus infection, Epstein–Barr virus and human immunodeficiency virus (HIV). These factors act, at least partly, by changing the genes of ...
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Tissue (biology)
In biology, tissue is a biological organizational level between cells and a complete organ. A tissue is an ensemble of similar cells and their extracellular matrix from the same origin that together carry out a specific function. Organs are then formed by the functional grouping together of multiple tissues. The English word "tissue" derives from the French word "tissu", the past participle of the verb tisser, "to weave". The study of tissues is known as histology or, in connection with disease, as histopathology. Xavier Bichat is considered as the "Father of Histology". Plant histology is studied in both plant anatomy and physiology. The classical tools for studying tissues are the paraffin block in which tissue is embedded and then sectioned, the histological stain, and the optical microscope. Developments in electron microscopy, immunofluorescence, and the use of frozen tissue-sections have enhanced the detail that can be observed in tissues. With these tools, the cla ...
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Irradiation
Irradiation is the process by which an object is exposed to radiation. The exposure can originate from various sources, including natural sources. Most frequently the term refers to ionizing radiation, and to a level of radiation that will serve a specific purpose, rather than radiation exposure to normal levels of background radiation. The term irradiation usually excludes the exposure to non-ionizing radiation, such as infrared, visible light, microwaves from cellular phones or electromagnetic waves emitted by radio and TV receivers and power supplies. Applications Sterilization If administered at appropriate levels, all forms of ionizing radiation can sterilize objects, including medical instruments, disposables such as syringes, and sterilize food. Ionizing radiation ( electron beams, X-rays and gamma rays) may be used to kill bacteria in food or other organic material, including blood. Food irradiation, while effective, is seldom used due to problems with public accep ...
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Pion
In particle physics, a pion (or a pi meson, denoted with the Greek letter pi: ) is any of three subatomic particles: , , and . Each pion consists of a quark and an antiquark and is therefore a meson. Pions are the lightest mesons and, more generally, the lightest hadrons. They are unstable, with the charged pions and decaying after a mean lifetime of 26.033 nanoseconds ( seconds), and the neutral pion decaying after a much shorter lifetime of 85 attoseconds ( seconds). Charged pions most often decay into muons and muon neutrinos, while neutral pions generally decay into gamma rays. The exchange of virtual pions, along with vector, rho and omega mesons, provides an explanation for the residual strong force between nucleons. Pions are not produced in radioactive decay, but commonly are in high-energy collisions between hadrons. Pions also result from some matter–antimatter annihilation events. All types of pions are also produced in natural processes ...
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Raster Scan
A raster scan, or raster scanning, is the rectangular pattern of image capture and reconstruction in television. By analogy, the term is used for raster graphics, the pattern of image storage and transmission used in most computer bitmap image systems. The word '' raster'' comes from the Latin word '' rastrum'' (a rake), which is derived from '' radere'' (to scrape); see also rastrum, an instrument for drawing musical staff lines. The pattern left by the lines of a rake, when drawn straight, resembles the parallel lines of a raster: this line-by-line scanning is what creates a raster. It is a systematic process of covering the area progressively, one line at a time. Although often a great deal faster, it is similar in the most general sense to how one's gaze travels when one reads lines of text. The data to be drawn is stored in an area of memory called the Framebuffer. This memory area holds the values for each pixel on the screen. These values are retrieved from the refresh ...
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