Canine Histiocytic Diseases

picture info	Canine Histiocytic Diseases Histiocytic diseases in dogs are a group of diseases in dogs which may involve the skin, and which can be difficult to differentiate from granulomatous, reactive inflammatory or lymphoproliferative diseases. The clinical presentation and behaviour as well as response to therapy vary greatly among the syndromes. There are at least four well-defined canine histiocytic diseases: :1. Canine cutaneous histiocytoma (derived from specialised epidermic dendritic cells, the Langerhans cells) :2. Reactive histiocytosis (immunohistochemical features show that interstitial/dermal DCs are involved) :2.a. Cutaneous histiocytosis (CH) :2.b. Systemic histiocytosis (SH) :3. Histiocytic sarcoma complex (immunohistochemical features of dendritic cells, possibly interdigitating or perivascular DCs) :3.a. Malignant histiocytosis :3.b. Histiocytic sarcoma Localized histiocytic sarcoma Diffuse histiocytic sarcoma Cutaneous histiocytoma Histiocytoma Histiocytoma is a common, benign, cutaneous neo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Histiocytosis In medicine, histiocytosis is an excessive number of histiocytes (tissue macrophages), and the term is also often used to refer to a group of rare diseases which share this sign as a characteristic. Occasionally and confusingly, the term "histiocytosis" is sometimes used to refer to individual diseases. According to the Histiocytosis Association of America, 1 in 200,000 children in the United States are born with histiocytosis each year. HAA also states that most of the people diagnosed with histiocytosis are children under the age of 10, although the disease can afflict adults. The disease usually occurs from birth to age 15. Histiocytosis (and malignant histiocytosis) are both important in veterinary as well as human pathology. Diagnosis Histiocytosis is a rare disease, thus its diagnosis may be challenging. A variety of tests may be used, including: * Imaging CT scans of various organs such as lung, heart and kidneys. MRI of the brain, pituitary gland, heart, among ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Histiocytic Sarcoma Histiocytic sarcoma is a tumor derived from histiocytes. The tumor is often positive for CD163 and can appear in the thyroid. However, in some cases it can also appear in the brain A brain is an organ (biology), organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It is located in the head, usually close to the sensory organs for senses such as Visual perception, vision. I .... References External links Sarcoma {{neoplasm-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Canine Histiocytoma Canine may refer to: Zoology and anatomy * a dog-like Canid animal in the subfamily Caninae ''Canis'', a genus including dogs, wolves, coyotes, and jackals Dog, the domestic dog * Canine tooth, in mammalian oral anatomy People with the surname * Henry Canine (), American football coach * Ralph Canine (1895–1969), founding director of the United States National Security Agency Other uses * Canine, a fictional dog in the '' Glenn Martin, DDS'' animated television series * Canine Hills, Antarctic landform in the Bowers Mountains, Victoria Land See also * K9 (other) * Kanine (other) * Canina (other) * Cani (other) * List of canids Canidae is a family of mammals in the order Carnivora, which includes domestic dogs, wolves, coyotes, foxes, jackals, dingoes, and many other extant and extinct dog-like mammals. A member of this family is called a canid; all extant species ... {{disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Histiocytoma A histiocytoma is a tumour consisting of histiocytes. Histiocytes are cells that are a part of the mononuclear phagocytic system, a part of the body's immune system that consists of phagocytic cells, which are responsible for engulfing solid particles by the cell membrane to form an internal phagosome by phagocytes and protists. Myxofibrosarcoma had been classified as a type of histiocytoma. However, the World Health Organization (2020) reclassified myxofibrosarcoma as a malignant tumor in the category of fibroblastic/myofibroblastic tumors. Types include: * benign fibrous histiocytoma: This tumor has also been termed benign fibrous histiocytomas of the skin, superficial/cutaneous benign fibrous histiocytomas, common fibrous histiocytoma, and more recently dermatofibroma. The use of "histiocytoma" in these terms refers more to the morphologic appearance of some of the cells that comprise these lesions rather than their lineage: studies to date have not fully determined the li ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Benign Tumor A benign tumor is a mass of cells (tumor) that does not invade neighboring tissue or metastasize (spread throughout the body). Compared to malignant (cancerous) tumors, benign tumors generally have a slower growth rate. Benign tumors have relatively well differentiated cells. They are often surrounded by an outer surface (fibrous sheath of connective tissue) or stay contained within the epithelium. Common examples of benign tumors include moles and uterine fibroids. Some forms of benign tumors may be harmful to health. Benign tumor growth causes a mass effect that can compress neighboring tissues. This can lead to nerve damage, blood flow reduction ( ischemia), tissue death ( necrosis), or organ damage. The health effects of benign tumor growth may be more prominent if the tumor is contained within an enclosed space such as the cranium, respiratory tract, sinus, or bones. For example, unlike most benign tumors elsewhere in the body, benign brain tumors can be life-threa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Lesion A lesion is any damage or abnormal change in the tissue of an organism, usually caused by disease or trauma. ''Lesion'' is derived from the Latin "injury". Lesions may occur in plants as well as animals. Types There is no designated classification or naming convention for lesions. Since lesions can occur anywhere in the body and the definition of a lesion is so broad, the varieties of lesions are virtually endless. Generally, lesions may be classified by their patterns, their sizes, their locations, or their causes. They can also be named after the person who discovered them. For example, Ghon lesions, which are found in the lungs of those with tuberculosis, are named after the lesion's discoverer, Anton Ghon. The characteristic skin lesions of a varicella zoster virus infection are called '' chickenpox''. Lesions of the teeth are usually called dental caries. Location Lesions are often classified by their tissue types or locations. For example, a "skin lesion" or a " b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Lymphoma In Animals Lymphoma (lymphosarcoma) in animals is a type of cancer defined by a proliferation of malignant lymphocytes within solid organs such as the lymph nodes, bone marrow, liver and spleen. The disease also may occur in the eye, skin, and gastrointestinal tract. Lymphoma in dogs Lymphoma is one of the most common malignant tumors to occur in dogs. The cause is genetic, but there are also suspected environmental factors involved, including in one study an increased risk with the use of the herbicide 2,4-D. This risk was not confirmed in another study. Breeds that are commonly affected include Boxer, Scottish Terrier, Basset Hound, Airedale Terrier, Chow Chow, German Shepherd, Poodle, St. Bernard, Bulldog, Beagle, Rottweiler and Golden Retriever. The Golden Retriever is especially susceptible to developing lymphoma, with a lifetime risk of 1:8. Classification The cancer is classified into low and high grade types. Classification is also based on location. The four location t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Langerhans Cell A Langerhans cell (LC) is a tissue-resident macrophage of the skin. These cells contain organelles called Birbeck granules. They are present in all layers of the epidermis and are most prominent in the stratum spinosum. They also occur in the papillary dermis, particularly around blood vessels, as well as in the mucosa of the mouth, foreskin, and vaginal epithelium. They can be found in other tissues, such as lymph nodes, particularly in association with the condition Langerhans cell histiocytosis (LCH). Function In skin infections, the local Langerhans cells take up and process microbial antigens to become fully functional antigen-presenting cells. Generally, tissue-resident macrophages are involved in immune homeostasis and the uptake of apoptotic bodies. However, Langerhans cells can also take on a dendritic cell-like phenotype and migrate to lymph nodes to interact with naive T-cells. Langerhans cells derive from primitive erythro-myeloid progenitors that arise in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Stertorous Stertor, from Latin 'stertere' to snore, and first used in 1804, is a noisy breathing sound like snoring.O Cathain E, Gaffey MMUpper Airway Obstruction In: StatPearls. StatPearls Publishing, Treasure Island (FL); 2020. It is caused by partial obstruction of the upper airways, at the level of the pharynx and nasopharynx. It is distinguished from stridor by its pitch. Stertor is low-pitched, and can occur when breathing in, out or both. Stertor and stridor can occur together, such as when adenotonsillar hypertrophy and laryngomalacia Laryngomalacia (literally, "soft larynx") is the most common cause of chronic stridor in infancy, in which the soft, immature cartilage of the upper larynx collapses inward during inhalation, causing airway obstruction. It can also be seen in olde ... occur together. References Respiration {{Med-sign-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]