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Combined Intracavernous Injection And Stimulation Test
Combined intracavernous injection and stimulation test or CIS test is the most commonly performed office diagnostic procedure for erectile dysfunction. It consists of an intracavernosal injection, visual or manual sexual stimulation, and a rating of the subsequent erection. Neurogenic and hormonal influences are thus bypassed as the status of the blood vessels of the penis is assessed directly and objectively. A rigid erection of more than 10 minutes indicates normal function of veins. The same conclusion cannot be made for the function of arteries An artery (plural arteries) () is a blood vessel in humans and most animals that takes blood away from the heart to one or more parts of the body (tissues, lungs, brain etc.). Most arteries carry oxygenated blood; the two exceptions are the pul ... as some men with mild arterial problems can also have the same response.Emil A. Tanagho, MD & Jack W. McAninch MD, FACS (ed., 2008), ''Smith's General Urology'', p. 597. Lange Medical Boo ...
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Erectile Dysfunction
Erectile dysfunction (ED), also called impotence, is the type of sexual dysfunction in which the penis fails to become or stay erect during sexual activity. It is the most common sexual problem in men.Cunningham GR, Rosen RC. Overview of male sexual dysfunction. In: UpToDate, Martin KA (Ed), UpToDate, Waltham, MA, 2018. Through its connection to self-image and to problems in sexual relationships, erectile dysfunction can cause psychological harm. In about 80% of cases, physical causes can be identified. These include cardiovascular disease; diabetes mellitus; neurological problems, such as those following prostatectomy; hypogonadism; and drug side effects. About 10% of cases are psychological impotence, caused by thoughts or feelings; here, there is a strong response to placebo treatment. The term ''erectile dysfunction'' is not used for other disorders of erection, such as priapism. Treatment involves addressing the underlying causes, lifestyle modifications, and ...
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Intracavernosal Injection
An intracavernous (or intracavernosal) injection is an injection into the base of the penis. This injection site is often used to administer medications to check for or treat erectile dysfunction in adult men (in, for example, a combined intracavernous injection and stimulation test). The more common medications administered in this manner include Caverject, Trimix (prostaglandin, papaverine, and phentolamine), Bimix (papaverine and phentolamine), and Quadmix (prostaglandin, papaverine, phentolamine, and either atropine or forskolin). These medications are all types of vasodilators and cause tumescence within 10-15 minutes. Common side effects include priapism, bruising, fibrosis, Peyronie's disease, and pain. Priapism is also often treated with intracavernous injections, usually with sympathomimetic vasoconstricting drugs like adrenaline or phenylephrine Phenylephrine is a medication primarily used as a decongestant, to dilate the pupil, to increase blood pressure, and to r ...
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Manual Sexual Stimulation
Non-penetrative sex or outercourse is sexual activity that usually does not include sexual penetration. It generally excludes the penetrative aspects of vaginal, anal, or oral sexual activity, but includes various forms of sexual and non-sexual activity, such as frottage, mutual masturbation, kissing, or cuddling.Se272 anpage 301 for two different definitions of outercourse (first of the pages for no-penetration definition; second of the pages for no-penile-penetration definition). Some forms of non-penetrative sex, particularly when termed ''outercourse,'' include penetrative aspects, such as penetration that may result from forms of fingering or oral sex. People engage in non-penetrative sex for a variety of reasons, including as a form of foreplay or as a primary or preferred sexual act.Sehere onwards anpages 47–49 for views on what constitutes virginity loss and therefore sexual intercourse or other sexual activity; source discusses how gay and lesbian individuals defi ...
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Erection
An erection (clinically: penile erection or penile tumescence) is a physiological phenomenon in which the penis becomes firm, engorged, and enlarged. Penile erection is the result of a complex interaction of psychological, neural, vascular, and endocrine factors, and is often associated with sexual arousal or sexual attraction, although erections can also be spontaneous. The shape, angle, and direction of an erection varies considerably between humans. Physiologically, an erection is required for a male to effect vaginal penetration or sexual intercourse and is triggered by the parasympathetic division of the autonomic nervous system, causing the levels of nitric oxide (a vasodilator) to rise in the trabecular arteries and smooth muscle of the penis. The arteries dilate causing the corpora cavernosa of the penis (and to a lesser extent the corpus spongiosum) to fill with blood; simultaneously the ischiocavernosus and bulbospongiosus muscles compress the veins of the ...
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Penis
A penis (plural ''penises'' or ''penes'' () is the primary sexual organ that male animals use to inseminate females (or hermaphrodites) during copulation. Such organs occur in many animals, both vertebrate and invertebrate, but males do not bear a penis in every animal species, and in those species in which the male does bear a so-called penis, the penises in the various species are not necessarily homologous. The term ''penis'' applies to many intromittent organs, but not to all. As an example, the intromittent organ of most cephalopoda is the hectocotylus, a specialized arm, and male spiders use their pedipalps. Even within the Vertebrata there are morphological variants with specific terminology, such as hemipenes. In most species of animals in which there is an organ that might reasonably be described as a penis, it has no major function other than intromission, or at least conveying the sperm to the female, but in the placental mammals the penis bears the d ...
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Veins
Veins are blood vessels in humans and most other animals that carry blood towards the heart. Most veins carry deoxygenated blood from the tissues back to the heart; exceptions are the pulmonary and umbilical veins, both of which carry oxygenated blood to the heart. In contrast to veins, arteries carry blood away from the heart. Veins are less muscular than arteries and are often closer to the skin. There are valves (called ''pocket valves'') in most veins to prevent backflow. Structure Veins are present throughout the body as tubes that carry blood back to the heart. Veins are classified in a number of ways, including superficial vs. deep, pulmonary vs. systemic, and large vs. small. *Superficial veins are those closer to the surface of the body, and have no corresponding arteries. * Deep veins are deeper in the body and have corresponding arteries. * Perforator veins drain from the superficial to the deep veins. These are usually referred to in the lower limbs and feet. * Co ...
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Arteries
An artery (plural arteries) () is a blood vessel in humans and most animals that takes blood away from the heart to one or more parts of the body (tissues, lungs, brain etc.). Most arteries carry oxygenated blood; the two exceptions are the pulmonary and the umbilical arteries, which carry deoxygenated blood to the organs that oxygenate it (lungs and placenta, respectively). The effective arterial blood volume is that extracellular fluid which fills the arterial system. The arteries are part of the circulatory system, that is responsible for the delivery of oxygen and nutrients to all cells, as well as the removal of carbon dioxide and waste products, the maintenance of optimum blood pH, and the circulation of proteins and cells of the immune system. Arteries contrast with veins, which carry blood back towards the heart. Structure The anatomy of arteries can be separated into gross anatomy, at the macroscopic level, and microanatomy, which must be studied with a micro ...
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