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Combination Chemotherapy
The era of cancer chemotherapy began in the 1940s with the first use of nitrogen mustards and folic acid antagonist drugs. The targeted therapy revolution has arrived, but many of the principles and limitations of chemotherapy discovered by the early researchers still apply. Beginnings The beginnings of the modern era of cancer chemotherapy can be traced directly to the German introduction of chemical warfare during World War I. Among the chemical agents used, mustard gas was particularly devastating. Although banned by the Geneva Protocol in 1925, the advent of World War II caused concerns over the possible re-introduction of chemical warfare. Such concerns led to the discovery of nitrogen mustard, a chemical warfare agent, as an effective treatment for some types of cancer. Two pharmacologists from the Yale School of Medicine, Louis S. Goodman and Alfred Gilman, Sr., Alfred Gilman, were recruited by the US Department of Defense to investigate potential therapeutic applicat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemotherapy Bottles NCI
Chemotherapy (often abbreviated chemo, sometimes CTX and CTx) is the type of cancer treatment that uses one or more anti-cancer drugs (list of chemotherapeutic agents, chemotherapeutic agents or alkylating agents) in a standard chemotherapy regimen, regimen. Chemotherapy may be given with a cure, curative intent (which almost always involves combinations of drugs), or it may aim only to prolong life or to Palliative care, reduce symptoms (Palliative care, palliative chemotherapy). Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called ''oncology#Specialties, medical oncology''. The term ''chemotherapy'' now means the non-specific use of intracellular poisons to inhibit mitosis (cell division) or to induce DNA damage (naturally occurring), DNA damage (so that DNA repair can augment chemotherapy). This meaning excludes the more-selective agents that block extracellular signals (signal transduction) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Non-Hodgkin's Lymphoma
Non-Hodgkin lymphoma (NHL), also known as non-Hodgkin's lymphoma, is a group of blood cancers that includes all types of lymphomas except Hodgkin lymphomas. Symptoms include enlarged lymph nodes, fever, night sweats, weight loss, and tiredness. Other symptoms may include bone pain, chest pain, or itchiness. Some forms are slow-growing while others are fast-growing. Unlike Hodgkin lymphoma, which spreads contiguously, NHL is largely a systemic illness. Signs and symptoms The signs and symptoms of non-Hodgkin lymphoma vary depending upon its location within the body. Symptoms include enlarged lymph nodes, fever, night sweats, weight loss, and tiredness. Other symptoms may include bone pain, chest pain, or itchiness. Some forms are slow growing, while others are fast growing. Enlarged lymph nodes may cause lumps to be felt under the skin when they are close to the surface of the body. Lymphomas in the skin may also result in lumps, which are commonly itchy, red, or purple ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jane Cooke Wright
Jane Cooke Wright (also known as "Jane Jones") (November 30, 1919 – February 19, 2013) was a pioneering cancer researcher and surgeon noted for her contributions to chemotherapy. In particular, Wright is credited with developing the technique of using human tissue culture rather than laboratory mice to test the effects of potential drugs on cancer cells. She also pioneered the use of the drug methotrexate to treat breast cancer and skin cancer ( mycosis fungoids). Early life, family, and education Wright's family had a strong history of academic achievement in medicine. She was born in 1919 in Manhattan, New York, to Corinne Cooke, a public school teacher, and Louis T. Wright, who was one of the first African American graduates from Harvard Medical School.Bruce Weber"Jane Wright, Oncology Pioneer, Dies at 93" ''The New York Times'' (obituary), March 2, 2013. He was the first African American doctor at a public hospital in New York City. During his 30 years working at the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sidney Farber Nci-vol-1926-300
Sidney may refer to: People * Sidney (surname), English surname * Sidney (given name), including a list of people with the given name * Sídney (footballer, born 1963) (Sídney José Tobias), Brazilian football forward * Sidney (footballer, born 1972) (Sidney da Silva Souza), Brazilian football defensive midfielder * Sidney (footballer, born 1979) (Sidney Santos de Brito), Brazilian football defender Fictional characters * Sidney Prescott, main character from the ''Scream'' horror trilogy * Sidney (''Ice Age''), a ground sloth in the ''Ice Age'' film series * Sidney, one of ''The Bash Street Kids'' * Sid Jenkins (Sidney Jenkins), a character in the British teen drama ''Skins'' * Sidney Hever, Edward's fireman from ''The Railway Series'' and the TV series ''Thomas and Friends''; see List of books in ''The Railway Series'' * Sidney, a diesel engine from the TV series; see List of ''Thomas & Friends'' characters * Sidney Freedman, a recurring character in the TV series ''M*A*S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Somatic Cell
In cellular biology, a somatic cell (), or vegetal cell, is any biological cell forming the body of a multicellular organism other than a gamete, germ cell, gametocyte or undifferentiated stem cell. Somatic cells compose the body of an organism and divide through mitosis. In contrast, gametes derive from meiosis within the germ cells of the germline and they fuse during sexual reproduction. Stem cells also can divide through mitosis, but are different from somatic in that they differentiate into diverse specialized cell types. In mammals, somatic cells make up all the internal organs, skin, bones, blood and connective tissue, while mammalian germ cells give rise to spermatozoa and ova which fuse during fertilization to produce a cell called a zygote, which divides and differentiates into the cells of an embryo. There are approximately 220 types of somatic cell in the human body. Theoretically, these cells are not germ cells (the source of gametes); they transmit their mut ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myeloid
Myeloid tissue, in the bone marrow sense of the word '' myeloid'' ('' myelo-'' + '' -oid''), is tissue of bone marrow, of bone marrow cell lineage, or resembling bone marrow, and myelogenous tissue (''myelo-'' + '' -genous'') is any tissue of, or arising from, bone marrow; in these senses the terms are usually used synonymously, as for example with chronic myeloid/myelogenous leukemia. In hematopoiesis, myeloid cells, or myelogenous cells are blood cells that arise from a progenitor cell for granulocytes, monocytes, erythrocytes, or platelets (the common myeloid progenitor, that is, CMP or CFU-GEMM), or in a narrower sense also often used, specifically from the lineage of the myeloblast (the myelocytes, monocytes, and their daughter types). Thus, although all blood cells, even lymphocytes, are normally born in the bone marrow in adults, myeloid cells in the narrowest sense of the term can be distinguished from lymphoid cells, that is, lymphocytes, which come from co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lymphoid
The lymphatic system, or lymphoid system, is an organ system in vertebrates that is part of the immune system and complementary to the circulatory system. It consists of a large network of lymphatic vessels, lymph nodes, lymphoid organs, lymphatic tissue and lymph. Lymph is a clear fluid carried by the lymphatic vessels back to the heart for re-circulation. The Latin word for lymph, , refers to the deity of fresh water, "Lympha". Unlike the circulatory system that is a closed system, the lymphatic system is open. The human circulatory system processes an average of 20 litres of blood per day through Starling equation, capillary filtration, which removes blood plasma, plasma from the blood. Roughly 17 litres of the filtered blood is reabsorbed directly into the blood vessels, while the remaining three litres are left in the interstitial fluid. One of the main functions of the lymphatic system is to provide an accessory return route to the blood for the surplus three litres. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autopsy
An autopsy (also referred to as post-mortem examination, obduction, necropsy, or autopsia cadaverum) is a surgical procedure that consists of a thorough examination of a corpse by dissection to determine the cause, mode, and manner of death; or the exam may be performed to evaluate any disease or injury that may be present for research or educational purposes. The term ''necropsy'' is generally used for non-human animals. Autopsies are usually performed by a specialized medical doctor called a pathologist. Only a small portion of deaths require an autopsy to be performed, under certain circumstances. In most cases, a medical examiner or coroner can determine the cause of death. Purposes of performance Autopsies are performed for either legal or medical purposes. Autopsies can be performed when any of the following information is desired: * Manner of death must be determined ** Determine if death was natural or unnatural ** Injury source and extent on the corpse * Pos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stewart Francis Alexander
Lieutenant-Colonel Stewart Francis Alexander (August 30, 1914 – December 6, 1991) was an American medical doctor from New Jersey and an expert on chemical warfare who was dispatched to attend the patients following the Air raid on Bari. Born and raised in Park Ridge, New Jersey, where his father was a family physician, Alexander attended Staunton Military Academy before enrolling at Dartmouth College and earning his medical degree from the Columbia University Medical School."Stewart F. Alexander Medical Specialist, 77" '''', December 11, 1991. Accessed August 18, 2020. "Dr. Stewart F. Alexander, a retired Ne ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bomb
A bomb is an explosive weapon that uses the exothermic reaction of an explosive material to provide an extremely sudden and violent release of energy. Detonations inflict damage principally through ground- and atmosphere-transmitted mechanical stress, the impact and penetration of pressure-driven projectiles, pressure damage, and explosion-generated effects. Bombs have been utilized since the 11th century starting in East Asia. The term ''bomb'' is not usually applied to explosive devices used for civilian purposes such as construction or mining, although the people using the devices may sometimes refer to them as a "bomb". The military use of the term "bomb", or more specifically aerial bomb action, typically refers to airdropped, unpowered explosive weapons most commonly used by air forces and naval aviation. Other military explosive weapons not classified as "bombs" include shells, depth charges (used in water), or land mines. In unconventional warfare, other names ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Harvey (ship)
SS ''John Harvey'' was a U.S. World War II Liberty ship. This ship is known for carrying a secret cargo of mustard gas and whose sinking by German aircraft in December 1943 at the port of Bari in south Italy caused an unintentional release of chemical weapons. The ''John Harvey'' was built by the North Carolina Shipbuilding Company in Wilmington, North Carolina, and launched on 9 January 1943. Her Maritime Commission Hull Number was 878, and she was rated as capable of carrying 504 soldiers. She was operated by Agwilines Inc. Bari incident In August 1943, Roosevelt approved the shipment of chemical munitions containing mustard agent to the Mediterranean theater. On 18 November 1943 the ''John Harvey'', commanded by Captain Elwin F. Knowles, sailed from Oran, Algeria, to Italy, carrying 2,000 M47A1 mustard gas bombs, each of which held 60–70 lb of sulfur mustard. After stopping for an inspection by an officer of the 7th Chemical Ordnance Company at Augusta, Sicily on 26 No ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Air Raid On Bari
The air raid on Bari (, ) was an air attack by German bombers on Allied forces and shipping in Bari, Italy, on 2 December 1943, during World War II. 105 German Junkers Ju 88 bombers of ''Luftflotte'' 2 surprised the port's defenders and bombed shipping and personnel operating in support of the Allied Italian Campaign, sinking 27 cargo and transport ships, as well as a schooner, in Bari harbour. The attack lasted a little more than an hour and put the port out of action until February 1944. The release of mustard gas from one of the wrecked cargo ships added to the loss of life. The British and US governments covered up the presence of mustard gas and its effects on victims of the raid. Background In early September 1943, coinciding with the Allied invasion of Italy, Italy surrendered to the Allies in the Armistice of Cassibile and changed sides, but the breakaway Italian Social Republic in central and northern Italy continued the war on the Axis side. On 11 September 1943, th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
