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Butterbur
''Petasites'' is a genus of flowering plants in the sunflower family, Asteraceae, that are commonly referred to as butterburs and coltsfoots.''Petasites''.
Flora of North America. Volume 20, Page 635. efloras.org.
They are perennial plants with thick, creeping underground s and large -like leaves during the growing season. Most species are native to Asia or southern Europe.


Characteristics

The short spikes of s are produced just before the leaves in lat ...
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Petasites Japonicus Russia
''Petasites'' is a genus of flowering plants in the sunflower family, Asteraceae, that are commonly referred to as butterburs and coltsfoots.''Petasites''.
Flora of North America. Volume 20, Page 635. efloras.org.
They are perennial plants with thick, creeping underground rhizomes and large rhubarb-like leaves during the growing season. Most species are native to Asia or southern Europe.


Characteristics

The short spikes of s are produced just before the leaves in late winter (e.g. ''

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Petasites Hybridus
''Petasites hybridus'', the butterbur, is a herbaceous perennial flowering plant in the family Asteraceae, native to Europe and northern Asia. Although used over centuries in traditional medicine to treat various disorders, there are no approved medical uses, but it is sold as a dietary supplement. Concerns about the potential toxic effects of pyrrolizidine alkaloids in butterbur limit its use in human and animal studies. Etymology and common names The botanical name ''Petasites'' derived from the Greek word, ''petasos'', from the plant's broad leaves resembling a wide-brimmed hat. ''Butterbur'' may have derived from the use of leaves to wrap butter centuries ago. It is also called ''bog rhubarb'', ''Devil's hat'', and ''pestilence wort''. Synonyms include ''P. officinalis'', ''P. ovatus'', ''P. vulgaris'', and ''Tussilago petasites'' L. Description The species is dioecious, the male and female flowers being borne on separate plants. In Britain, the male flowers are widespread, ...
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Migraine
Migraine (, ) is a common neurological disorder characterized by recurrent headaches. Typically, the associated headache affects one side of the head, is pulsating in nature, may be moderate to severe in intensity, and could last from a few hours to three days. Non-headache symptoms may include nausea, vomiting, and sensitivity to light, sound, or smell. The pain is generally made worse by physical activity during an attack,as PDF
although regular physical exercise may prevent future attacks. Up to one-third of people affected have : typically, it ...
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Migraines
Migraine (, ) is a common neurological disorder characterized by recurrent headaches. Typically, the associated headache affects one side of the head, is pulsating in nature, may be moderate to severe in intensity, and could last from a few hours to three days. Non-headache symptoms may include nausea, vomiting, and sensitivity to light, sound, or smell. The pain is generally made worse by physical activity during an attack,as PDF
although regular physical exercise may prevent future attacks. Up to one-third of people affected have : typically, ...
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Tussilago
''Tussilago farfara'', commonly known as coltsfoot, is a plant in the tribe Senecioneae in the family Asteraceae, native to Europe and parts of western and central Asia. The name "tussilago" is derived from the Latin ''tussis'', meaning cough, and ''ago'', meaning to cast or to act on. It has had uses in traditional medicine, but the discovery of toxic pyrrolizidine alkaloids in the plant has resulted in liver health concerns. ''Tussilago farfara'' is the only accepted species in the genus ''Tussilago'', although more than two dozen other species have at one time or another been considered part of this group. Most of them are now regarded as members of other genera ''( Chaptalia, Chevreulia, Farfugium, Homogyne, Leibnitzia, Petasites, Senecio).''Flann, C (ed) 2009+ Global Composi ...
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Rhizome
In botany and dendrology, a rhizome (; , ) is a modified subterranean plant stem that sends out roots and shoots from its nodes. Rhizomes are also called creeping rootstalks or just rootstalks. Rhizomes develop from axillary buds and grow horizontally. The rhizome also retains the ability to allow new shoots to grow upwards. A rhizome is the main stem of the plant that runs underground horizontally. A stolon is similar to a rhizome, but a stolon sprouts from an existing stem, has long internodes, and generates new shoots at the end, such as in the strawberry plant. In general, rhizomes have short internodes, send out roots from the bottom of the nodes, and generate new upward-growing shoots from the top of the nodes. A stem tuber is a thickened part of a rhizome or stolon that has been enlarged for use as a storage organ. In general, a tuber is high in starch, e.g. the potato, which is a modified stolon. The term "tuber" is often used imprecisely and is sometimes applied ...
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Allergic Rhinitis
Allergic rhinitis, of which the seasonal type is called hay fever, is a type of inflammation in the nose that occurs when the immune system overreacts to allergens in the air. Signs and symptoms include a runny or stuffy nose, sneezing, red, itchy, and watery eyes, and swelling around the eyes. The fluid from the nose is usually clear. Symptom onset is often within minutes following allergen exposure, and can affect sleep and the ability to work or study. Some people may develop symptoms only during specific times of the year, often as a result of pollen exposure. Many people with allergic rhinitis also have asthma, allergic conjunctivitis, or atopic dermatitis. Allergic rhinitis is typically triggered by environmental allergens such as pollen, pet hair, dust, or mold. Inherited genetics and environmental exposures contribute to the development of allergies. Growing up on a farm and having multiple siblings decreases this risk. The underlying mechanism involves IgE antibodi ...
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Carbamazepine
Carbamazepine (CBZ), sold under the trade name Tegretol among others, is an anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain. It is used as an adjunctive treatment in schizophrenia along with other medications and as a second-line agent in bipolar disorder. Carbamazepine appears to work as well as phenytoin and valproate for focal and generalized seizures. It is not effective for absence or myoclonic seizures. Carbamazepine was discovered in 1953 by Swiss chemist Walter Schindler. It was first marketed in 1962. It is available as a generic medication. It is on the World Health Organization's List of Essential Medicines. In 2020, it was the 185th most commonly prescribed medication in the United States, with more than 2million prescriptions. Medical uses Carbamazepine is typically used for the treatment of seizure disorders and neuropathic pain. It is used off-label as a second-line treatment for bipolar disorder and in combin ...
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CYP3A4
Cytochrome P450 3A4 (abbreviated CYP3A4) () is an important enzyme in the body, mainly found in the liver and in the intestine. It oxidizes small foreign organic molecules ( xenobiotics), such as toxins or drugs, so that they can be removed from the body. It is highly homologous to CYP3A5, another important CYP3A enzyme. While many drugs are deactivated by CYP3A4, there are also some drugs which are ''activated'' by the enzyme. Some substances, such as some drugs and furanocoumarins present in grapefruit juice, interfere with the action of CYP3A4. These substances will therefore either amplify or weaken the action of those drugs that are modified by CYP3A4. CYP3A4 is a member of the cytochrome P450 family of oxidizing enzymes. Several other members of this family are also involved in drug metabolism, but CYP3A4 is the most common and the most versatile one. Like all members of this family, it is a hemoprotein, i.e. a protein containing a heme group with an iron atom. In huma ...
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Enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyze individual steps. The study of enzymes is called ''enzymology'' and the field of pseudoenzyme analysis recognizes that during evolution, some enzymes have lost the ability to carry out biological catalysis, which is often reflected in their amino acid sequences and unusual 'pseudocatalytic' properties. Enzymes are known to catalyze more than 5,000 biochemical reaction types. Other biocatalysts are catalytic RNA molecules, called ribozymes. Enzymes' specificity comes from their unique three-dimensional structures. Like all catalysts, enzymes increase the react ...
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Journal Of The National Cancer Institute
The ''Journal of the National Cancer Institute'' (''JNCI'') is a peer-reviewed medical journal covering research in oncology that was established in August 1940. It is published monthly by Oxford University Press and is edited by Patricia A. Ganz. It was merged with ''Cancer Treatment Reports'' in January 1988. ''JNCI'' used to be the official journal of the National Cancer Institute (NCI); however, in 1996, the NCI and ''JNCI'' agreed to grow apart. Over the next five years, ''JNCI'' became independent of the NCI. A related publication is ''Journal of the National Cancer Institute Monographs'' (''JNCI Monographs''), established in 1959, which publishes manuscripts from cancer and cancer-related conferences, as well as groups of papers on specific subjects related to cancer. In January 1986, ''Cancer Treatment Symposia'' was merged with ''JNCI Monographs''. Additionally, ''JNCI Cancer Spectrum'' (''JNCI CS'') is a fully open access journal, which was established in 2017. It is ...
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Rhizomes
In botany and dendrology, a rhizome (; , ) is a modified subterranean plant stem that sends out roots and shoots from its nodes. Rhizomes are also called creeping rootstalks or just rootstalks. Rhizomes develop from axillary buds and grow horizontally. The rhizome also retains the ability to allow new shoots to grow upwards. A rhizome is the main stem of the plant that runs underground horizontally. A stolon is similar to a rhizome, but a stolon sprouts from an existing stem, has long internodes, and generates new shoots at the end, such as in the strawberry plant. In general, rhizomes have short internodes, send out roots from the bottom of the nodes, and generate new upward-growing shoots from the top of the nodes. A stem tuber is a thickened part of a rhizome or stolon that has been enlarged for use as a storage organ. In general, a tuber is high in starch, e.g. the potato, which is a modified stolon. The term "tuber" is often used imprecisely and is sometimes applied ...
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