|
Bemegride
Bemegride (trademarked as Megimide) is a central nervous system stimulant. The drug was first made in 1911. It has been used in hypnotic overdose. As with other chemoreceptor agonists, it is a potent emetic at doses above those normally used in management of barbiturate overdose although emesis and aspiration are a concern during treatment. It is a controlled substance in some countries. Animal use Bemegride is also used to induce convulsions in experimental animals. Synthesis The original synthesis involves first the condensation of methylethylketone with two equivalents of cyanoacetamide. The product can be rationalized by assuming first aldol condensation of ketone and active methylene compound followed by dehydration to give 3. Conjugate addition of a second molecule of cyanoacetamide would afford 4. Addition of one of the amide amines to the nitrile would then afford the iminonitrile 5. The observed product 6 can be rationalized by assuming loss of the carboxamide u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bemegride Synthesis
Bemegride (trademarked as Megimide) is a central nervous system stimulant. The drug was first made in 1911. It has been used in hypnotic overdose. As with other chemoreceptor agonists, it is a potent emetic at doses above those normally used in management of barbiturate overdose although emesis and aspiration are a concern during treatment. It is a controlled substance in some countries. Animal use Bemegride is also used to induce convulsions in experimental animals. Synthesis The original synthesis involves first the condensation of methylethylketone with two equivalents of cyanoacetamide. The product can be rationalized by assuming first aldol condensation of ketone and active methylene compound followed by dehydration to give 3. Conjugate addition of a second molecule of cyanoacetamide would afford 4. Addition of one of the amide amines to the nitrile would then afford the iminonitrile 5. The observed product 6 can be rationalized by assuming loss of the carboxamide u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Convulsants
A convulsant is a drug which induces convulsions and/or epileptic seizures, the opposite of an anticonvulsant. These drugs generally act as stimulants at low doses, but are not used for this purpose due to the risk of convulsions and consequent excitotoxicity. Most convulsants are antagonists (or inverse agonists) at either the GABAA or glycine receptors, or ionotropic glutamate receptor agonists. Many other drugs may cause convulsions as a side effect at high doses (e.g. bupropion, tramadol, pethidine, dextropropoxyphene, clomipramine) but only drugs whose primary action is to cause convulsions are known as convulsants. Nerve agents such as sarin, which were developed as chemical weapons, produce convulsions as a major part of their toxidrome, but also produce a number of other effects in the body and are usually classified separately. Dieldrin which was developed as an insecticide blocks chloride influx into the neurons causing hyperexcitability of the CNS and convu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Bodkin Adams
John Bodkin Adams (21 January 18994 July 1983) was an Irish-born British general practitioner, convicted fraudster, and suspected serial killer. Between 1946 and 1956, 163 of his patients died while in comas, which was deemed to be worthy of investigation. In addition, 132 out of 310 patients had left Adams money or items in their wills. Adams was tried and acquitted for the murder of one patient in 1957, while another count of murder was withdrawn by the prosecution in what was later described as "an abuse of process" by the presiding judge Patrick Devlin, Baron Devlin, causing questions to be asked in Parliament of the United Kingdom about the prosecution's handling of events. Adams was found guilty in a subsequent trial of thirteen offences of prescription drug fraud, lying on cremation forms, obstruction of justice during a police search, and failing to keep a dangerous drugs register. He was struck off by the General Medical Council in 1957 and reinstated in 1961 af ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Central Nervous System
The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord. The CNS is so named because the brain integrates the received information and coordinates and influences the activity of all parts of the bodies of bilaterally symmetric and triploblastic animals—that is, all multicellular animals except sponges and diploblasts. It is a structure composed of nervous tissue positioned along the rostral (nose end) to caudal (tail end) axis of the body and may have an enlarged section at the rostral end which is a brain. Only arthropods, cephalopods and vertebrates have a true brain (precursor structures exist in onychophorans, gastropods and lancelets). The rest of this article exclusively discusses the vertebrate central nervous system, which is radically distinct from all other animals. Overview In vertebrates, the brain and spinal cord are both enclosed in the meninges. The meninges provide a barrier to chemicals ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serial Killer
A serial killer is typically a person who murders three or more persons,A * * * * with the murders taking place over more than a month and including a significant period of time between them. While most authorities set a threshold of three murders, others extend it to four or lessen it to two. Psychological gratification is the usual motive for serial killing, and many serial murders involve sexual contact with the victim. The Federal Bureau of Investigation (FBI) states that the motives of serial killers can include anger, thrill-seeking, financial gain, and attention seeking, and killings may be executed as such. The victims may have something in common; for example, demographic profile, appearance, gender or race. Often the FBI will focus on a particular pattern serial killers follow. Based on this pattern, this will give key clues into finding the killer along with their motives. Although a serial killer is a distinct classification that differs from that of a mass mu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Respiratory Agents
The respiratory system (also respiratory apparatus, ventilatory system) is a biological system consisting of specific organs and structures used for gas exchange in animals and plants. The anatomy and physiology that make this happen varies greatly, depending on the size of the organism, the environment in which it lives and its evolutionary history. In land animals the respiratory surface is internalized as linings of the lungs. Gas exchange in the lungs occurs in millions of small air sacs; in mammals and reptiles these are called alveoli, and in birds they are known as atria. These microscopic air sacs have a very rich blood supply, thus bringing the air into close contact with the blood. These air sacs communicate with the external environment via a system of airways, or hollow tubes, of which the largest is the trachea, which branches in the middle of the chest into the two main bronchi. These enter the lungs where they branch into progressively narrower secondary and ter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stimulants
Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and invigorating, or drugs that have sympathomimetic effects. Stimulants are widely used throughout the world as prescription medicines as well as without a prescription (either legally or illicitly) as performance-enhancing or recreational drugs. Among narcotics, stimulants produce a noticeable crash or '' comedown'' at the end of their effects. The most frequently prescribed stimulants as of 2013 were lisdexamfetamine (Vyvanse), methylphenidate (Ritalin), and amphetamine (Adderall). It was estimated in 2015 that the percentage of the world population that had used cocaine during a year was 0.4%. For the category "amphetamines and prescription stimulants" (with "amphetamines" including amphetamine and methamphetamine) the value was 0.7%, an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antidotes
An antidote is a substance that can counteract a form of poisoning. The term ultimately derives from the Greek term φάρμακον ἀντίδοτον ''(pharmakon) antidoton'', "(medicine) given as a remedy". Antidotes for anticoagulants are sometimes referred to as reversal agents. The antidotes for some particular toxins are manufactured by injecting the toxin into an animal in small doses and extracting the resulting antibodies from the host animals' blood. This results in an antivenom that can be used to counteract venom produced by certain species of snakes, spiders, and other venomous animals. Some animal venoms, especially those produced by arthropods (such as certain spiders, scorpions, and bees) are only potentially lethal when they provoke allergic reactions and induce anaphylactic shock; as such, there is no "antidote" for these venoms; however anaphylactic shock can be treated (e.g. with epinephrine). Some other toxins have no known antidote. For example, the p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cubic Centimetre
A cubic centimetre (or cubic centimeter in US English) (SI unit symbol: cm3; non-SI abbreviations: cc and ccm) is a commonly used unit of volume that corresponds to the volume of a cube that measures 1 cm × 1 cm × 1 cm. One cubic centimetre corresponds to a volume of one millilitre. The mass of one cubic centimetre of water at 3.98 °C (the temperature at which it attains its maximum density) is almost equal to one gram. In internal combustion engines, "cc" refers to the total volume of its engine displacement in cubic centimetres. The displacement can be calculated using the formula :d = \times b^2 \times s \times n where is engine displacement, is the bore of the cylinders, is length of the stroke and is the number of cylinders. Conversions *1 millilitre = 1 cm3 *1 litre = 1000 cm3 *1 cubic inch = . Unicode character The "cubic centimetre" symbol is encoded by Unicode at code point . See also * Cubic inch The cubic inch (s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gertrude Hullett
Gertrude or Gertrud may refer to: Places In space *Gertrude (crater), a crater on Uranus's moon Titania *710 Gertrud, a minor planet Terrestrial placenames * Gertrude, Arkansas * Gertrude, Washington * Gertrude, West Virginia People * Gertrude (given name), a given name (including a list of people with the name) People with Gertrude as the full name: *Blessed Gertrude of Aldenberg (1227–1297), daughter of Saint Elizabeth of Thuringia and abbess near Trier * Gertrude of Austria (1226–1288), Duchess of Austria and Styria * Gertrude of Babenberg (c.1118–1150), Duchess of Bohemia * Gertrude of Baden (c.1160–1225), Margravine of Baden *Gertrude of Bavaria (died 1197), daughter of Henry the Lion, Queen consort of Denmark * Gertrude of Brunswick (c.1060–1117), Margravine of Frisia and Meissen * Gertrude of Comburg (died 1130), Queen consort of Germany *Gertrude of Dagsburg (died 1225), Duchess of Lorraine * Gertrude of Delft (died 1358), Dutch Beguine and mystic *Gertrude of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carboxamide
In organic chemistry, an amide, also known as an organic amide or a carboxamide, is a compound with the general formula , where R, R', and R″ represent organic groups or hydrogen atoms. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. It can be viewed as a derivative of a carboxylic acid () with the hydroxyl group () replaced by an amine group (); or, equivalently, an acyl (alkanoyl) group () joined to an amine group. Common examples of amides are acetamide (), benzamide (), and dimethylformamide (). Amides are qualified as primary, secondary, and tertiary according to whether the amine subgroup has the form , , or , where R and R' are groups other than hydrogen. The core of amides is called the amide group (specifically, carboxamide group). Amides are pervasive in nature and technology. Proteins and important plasti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stimulant
Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and invigorating, or drugs that have sympathomimetic effects. Stimulants are widely used throughout the world as prescription medicines as well as without a prescription (either legally or illicitly) as performance-enhancing or recreational drugs. Among narcotics, stimulants produce a noticeable crash or '' comedown'' at the end of their effects. The most frequently prescribed stimulants as of 2013 were lisdexamfetamine (Vyvanse), methylphenidate (Ritalin), and amphetamine (Adderall). It was estimated in 2015 that the percentage of the world population that had used cocaine during a year was 0.4%. For the category "amphetamines and prescription stimulants" (with "amphetamines" including amphetamine and methamphetamine) the value was 0.7%, an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
.svg "Click for more on -> Carboxamide")
