Apicomplexans
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Apicomplexans
The Apicomplexa (also called Apicomplexia) are a large phylum of parasitic alveolates. Most of them possess a unique form of organelle that comprises a type of non-photosynthetic plastid called an apicoplast, and an apical complex structure. The organelle is an adaptation that the apicomplexan applies in penetration of a host cell. The Apicomplexa are unicellular and spore-forming. All species are obligate endoparasites of animals, except '' Nephromyces'', a symbiont in marine animals, originally classified as a chytrid fungus. Motile structures such as flagella or pseudopods are present only in certain gamete stages. The Apicomplexa are a diverse group that includes organisms such as the coccidia, gregarines, piroplasms, haemogregarines, and plasmodia. Diseases caused by Apicomplexa include: * Babesiosis (''Babesia'') * Malaria (''Plasmodium'') * Cryptosporidiosis (''Cryptosporidium parvum'') * Cyclosporiasis (''Cyclospora cayetanensis'') * Cystoisosporiasis (''Cystoi ...
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Plasmodium
''Plasmodium'' is a genus of unicellular eukaryotes that are obligate parasites of vertebrates and insects. The life cycles of ''Plasmodium'' species involve development in a blood-feeding insect host which then injects parasites into a vertebrate host during a blood meal. Parasites grow within a vertebrate body tissue (often the liver) before entering the bloodstream to infect red blood cells. The ensuing destruction of host red blood cells can result in malaria. During this infection, some parasites are picked up by a blood-feeding insect (mosquitoes in majority cases), continuing the life cycle. ''Plasmodium'' is a member of the phylum Apicomplexa, a large group of parasitic eukaryotes. Within Apicomplexa, ''Plasmodium'' is in the order Haemosporida and family Plasmodiidae. Over 200 species of ''Plasmodium'' have been described, many of which have been subdivided into 14 subgenera based on parasite morphology and host range. Evolutionary relationships among different ''Pl ...
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Nephromyces
''Nephromyces'' is a genus of apicomplexans that are symbionts of the ascidian genus ''Molgula'' (sea grapes). Systematics ''Nephromyces'' was first described in 1888 by Alfred Mathieu Giard as a chytrid fungus, because of its filamentous cells. He formally named three species, each corresponding to a different species of the host animal. Molecular phylogenetics later showed that ''Nephromyces'' are not actually fungi, but instead constitute a group within the Apicomplexa that is related to the Piroplasmida. Species of ''Nephromyces'' * ''Nephromyces molgularum'' Giard, 1888 * ''Nephromyces rosocovitanus'' Giard, 1888 * ''Nephromyces sorokini'' Giard, 1888 Description ''Nephromyces'' is found in the lumen of the renal sac of its host animals. The renal sac is a closed, fluid-filled structure that is derived from the epicardium during development. There are different cell types (at least seven in ''Nephromyces'' from ''Molgula manhattensis'') which appear to be different ...
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Gregarine
The gregarines are a group of Apicomplexan alveolates, classified as the Gregarinasina or Gregarinia. The large (roughly half a millimeter) parasites inhabit the intestines of many invertebrates. They are not found in any vertebrates. However, gregarines are closely related to both ''Toxoplasma'' and ''Plasmodium'', which cause toxoplasmosis and malaria, respectively. Both protists use protein complexes similar to those that are formed by the gregarines for gliding motility and invading target cells. This makes them excellent models for studying gliding motility with the goal of developing treatment options for toxoplasmosis and malaria. Thousands of different species of gregarines are expected to be found in insects, and 99% of these gregarines still need to be described. Each insect can be the host of multiple species. One of the most studied gregarines is ''Gregarina garnhami''. In general, gregarines are regarded as very successful parasites, as their hosts are spread over the ...
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Coccidia
Coccidia (Coccidiasina) are a subclass of microscopic, spore-forming, single-celled obligate intracellular parasites belonging to the apicomplexan class Conoidasida. As obligate intracellular parasites, they must live and reproduce within an animal cell. Coccidian parasites infect the intestinal tracts of animals, and are the largest group of apicomplexan protozoa. Infection with these parasites is known as coccidiosis. Coccidia can infect all mammals, some birds, some fish, some reptiles, and some amphibians. Most species of coccidia are species-specific in their host. An exception is ''Toxoplasma gondii'', which can infect all mammals, although it can only undergo sexual reproduction in cats. Depending on the species of coccidia, infection can cause fever, vomiting, diarrhea, muscle pain, and nervous system effects and changes to behavior, and may lead to death. Healthy adults may recover without medication—but those who are immunocompromised or young almost certainly requi ...
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Coccidiasina
Coccidia (Coccidiasina) are a subclass of microscopic, spore-forming, single-celled obligate intracellular parasites belonging to the apicomplexan class Conoidasida. As obligate intracellular parasites, they must live and reproduce within an animal cell. Coccidian parasites infect the intestinal tracts of animals, and are the largest group of apicomplexan protozoa. Infection with these parasites is known as coccidiosis. Coccidia can infect all mammals, some birds, some fish, some reptiles, and some amphibians. Most species of coccidia are species-specific in their host. An exception is ''Toxoplasma gondii'', which can infect all mammals, although it can only undergo sexual reproduction in cats. Depending on the species of coccidia, infection can cause fever, vomiting, diarrhea, muscle pain, and nervous system effects and changes to behavior, and may lead to death. Healthy adults may recover without medication—but those who are immunocompromised or young almost certainly requi ...
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Gregarinia
The gregarines are a group of Apicomplexan alveolates, classified as the Gregarinasina or Gregarinia. The large (roughly half a millimeter) parasites inhabit the intestines of many invertebrates. They are not found in any vertebrates. However, gregarines are closely related to both ''Toxoplasma'' and ''Plasmodium'', which cause toxoplasmosis and malaria, respectively. Both protists use protein complexes similar to those that are formed by the gregarines for gliding motility and invading target cells. This makes them excellent models for studying gliding motility with the goal of developing treatment options for toxoplasmosis and malaria. Thousands of different species of gregarines are expected to be found in insects, and 99% of these gregarines still need to be described. Each insect can be the host of multiple species. One of the most studied gregarines is ''Gregarina garnhami''. In general, gregarines are regarded as very successful parasites, as their hosts are spread over the ...
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Gregarinasina
The gregarines are a group of Apicomplexan alveolates, classified as the Gregarinasina or Gregarinia. The large (roughly half a millimeter) parasites inhabit the intestines of many invertebrates. They are not found in any vertebrates. However, gregarines are closely related to both ''Toxoplasma'' and ''Plasmodium'', which cause toxoplasmosis and malaria, respectively. Both protists use protein complexes similar to those that are formed by the gregarines for gliding motility and invading target cells. This makes them excellent models for studying gliding motility with the goal of developing treatment options for toxoplasmosis and malaria. Thousands of different species of gregarines are expected to be found in insects, and 99% of these gregarines still need to be described. Each insect can be the host of multiple species. One of the most studied gregarines is ''Gregarina garnhami''. In general, gregarines are regarded as very successful parasites, as their hosts are spread over the ...
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Coccidia
Coccidia (Coccidiasina) are a subclass of microscopic, spore-forming, single-celled obligate intracellular parasites belonging to the apicomplexan class Conoidasida. As obligate intracellular parasites, they must live and reproduce within an animal cell. Coccidian parasites infect the intestinal tracts of animals, and are the largest group of apicomplexan protozoa. Infection with these parasites is known as coccidiosis. Coccidia can infect all mammals, some birds, some fish, some reptiles, and some amphibians. Most species of coccidia are species-specific in their host. An exception is ''Toxoplasma gondii'', which can infect all mammals, although it can only undergo sexual reproduction in cats. Depending on the species of coccidia, infection can cause fever, vomiting, diarrhea, muscle pain, and nervous system effects and changes to behavior, and may lead to death. Healthy adults may recover without medication—but those who are immunocompromised or young almost certainly requi ...
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Plastid
The plastid (Greek: πλαστός; plastós: formed, molded – plural plastids) is a membrane-bound organelle found in the Cell (biology), cells of plants, algae, and some other eukaryotic organisms. They are considered to be intracellular endosymbiotic cyanobacteria. Examples include chloroplasts (used for photosynthesis), chromoplasts (used for pigment synthesis and storage), and leucoplasts (non-pigmented plastids that can sometimes differentiate). The event which led to permanent endosymbiosis in the Archaeplastida clade (of Embryophyte, land plants, red algae, and green algae) probably occurred with a cyanobiont (a symbiotic cyanobacteria) related to the genus ''Gloeomargarita lithophora, Gloeomargarita'', around 1.5 billion years ago. A later primary endosymbiosis event occurred in photosynthetic ''Paulinella'' amoeboids about 90–140 million years ago. This plastid belongs to the "PS-clade" (of the cyanobacteria genera ''Prochlorococcus'' and ''Synechococcus''). Chloroplas ...
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Plasmodiidae
The Plasmodiidae are a family (biology), family of apicomplexan parasites, including the type genus ''Plasmodium'', which is responsible for malaria. This family was erected in 1903 by Mesnil and is one of the four families in the Order (biology), order Haemospororida. Diagnostic criteria The diagnostic criteria of the Plasmodiidae are: * Macrogametes and microgamonts develop independently * Meiosis is absent * Microgametocyte produces eight flagellated microgametes * Zygote is motile (known as an ookinete) * Conoid present in ookinete stage only * Sporozoites naked in oocyst (that is without a Apicomplexa lifecycle stages, sporocyst) * Sporozoites have three walls * Heteroxenous: Protozoal merogony, merogony and Apicomplexan life cycle#gametogony, gamogony occur in vertebrate host, and fertilization and sporogony in definitive host (a blood-sucking insect) * Hemozoin pigment is produced Taxonomy The family Plasmodiidae has three sister taxa in the order Haemospororida: the f ...
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Piroplasm
Piroplasmida is an order of parasites in the phylum Apicomplexa. They divide by binary fission and as sporozoan parasites they possess sexual and asexual phases (sexual reproduction occurs in the tick gut). They include the tick parasites ''Babesia'' and ''Theileria''. Description They are minute rounded or pyriform parasites found within erythrocytes, or other circulating or endothelial cells of vertebrates, where they reproduce by merogony. The trophozoite stage is separated from erythrocyte by a single membrane. This distinguishes them from other blood parasites that usually have at least two membranes. An apical complex with a polar ring and rhopteries occurs, but without a conoid and usually without associated pellicular microtubules. They lack flagella and do not form either oocysts or spores. The known vectors are ticks or leeches in which they undergo sporogony; sexual reproduction probably occurs in the vector. See also * Babesiosis Babesiosis or piroplasmos ...
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Haemogregarine
''Adeleorina'' is a suborder of parasites in the phylum Apicomplexa. History Léger proposed this taxon in 1911. The first species identified was '' Dactylosoma ranarum'' by Lankester (1871) in a frog in Europe. It was initially called ''Undulina ranarum'', but this was changed in 1882 to ''Drepanidium ranarum''. This species was subsequently moved to the genus ''Dactylosoma''. Canine hepatozoonosis was first described in India in 1905 by James. The organism was named ''Leukocytozoon canis''. The vector was identified in 1907 by Christopher to be the brown dog tick (''Rhipicephalus sanguineus''). The genus '' Hepatozoon'' was created by Miller in 1908 for a parasite of the white rat (''Rattus norvegicus'') that underwent merogony in the liver and sporogony in the mite '' Laelap echidinus''. Ledger initially placed this genus in the family Haemogregarinidae, but Wenyon subsequently removed it and placed it in the newly created taxon Hepatozoidae in 1926. Life cycle All species ...
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