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Azoospermia
Azoospermia is the medical condition of a man whose semen contains no sperm. It is associated with male infertility, but many forms are amenable to medical treatment. In humans, azoospermia affects about 1% of the male population and may be seen in up to 20% of male infertility situations in Canada. In a non-pathological context, azoospermia is also the intended result of a vasectomy. Classification Azoospermia can be classified into three major types. Many conditions listed may also cause various degrees of oligospermia rather than azoospermia. Pretesticular and testicular azoospermia are known as non-obstructive azoospermia, whereas post-testicular azoospermia is considered obstructive. Pretesticular Inadequate stimulation of normal testicles and the genital tract characterizes pretesticular azoospermia. Typically, follicle-stimulating hormone (FSH) levels are low (hypogonadotropic), commensurate with inadequate stimulation of the testes to produce sperm. Examples include ...
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Semen Analysis
A semen analysis (plural: semen analyses), also called seminogram or spermiogram, evaluates certain characteristics of a male's semen and the spermatozoon, sperm contained therein. It is done to help evaluate male fertility, whether for those seeking pregnancy or verifying the success of vasectomy. Depending on the measurement method, just a few characteristics may be evaluated (such as with a home kit) or many characteristics may be evaluated (generally by a diagnostic laboratory). Collection techniques and precise measurement method may influence results. The assay is also referred to as ejaculate analysis, human sperm assay (HSA), sperm function test, and sperm assay. Semen analysis is a complex test that should be performed in andrology laboratories by experienced technicians with quality control and validation of test systems. A routine semen analysis should include: physical characteristics of semen (color, odor, pH, viscosity and liquefaction), volume, concentration, morp ...
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Male Infertility
Male infertility refers to a sexually mature male's inability to impregnate a fertile female. Male infertility can wholly or partially account for 40% of infertility among couples who are trying to have children. "A problem with the male is the sole cause, or a contributing cause, of infertility in about 40 percent of infertile couples. It affects approximately 7% of all men. Male infertility is commonly due to deficiencies in the semen, and semen quality is used as a surrogate measure of male fecundity. More recently, advance sperm analyses that examine intracellular sperm components are being developed. Age considerations Sperm motility increases from puberty through one's mid-thirties. Research shows that from the age of 36 onwards, sperm motility decreases from 40% Grade A & B to 31% in one's 50s. The effects of aging on semen quality is summarized below based on a study of 1,219 subjects: 90% of seminiferous tubules in men in their 20s and 30s contain spermatids, whereas ...
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Sertoli Cell-only Syndrome
Sertoli cell-only syndrome (SCOS), also known as germ cell aplasia, is defined by azoospermia where the testicular seminiferous tubules are lined solely with sertoli cells. Sertoli cells contribute to the formation of the blood-testis barrier and aid in sperm generation. These cells respond to follicle-stimulating hormone, which is secreted by the hypothalamus and aids in spermatogenesis. Men often learn they have Sertoli cell-only syndrome between the ages of 20 and 40 when they are checked for infertility and found to produce no sperm. Other signs and symptoms are uncommon, yet in some cases, an underlying cause of SCO syndrome, such as Klinefelter syndrome, may produce other symptoms. Most cases of SCO syndrome are idiopathic, however, causes may include deletions of genetic material on Y-chromosome regions, particularly the azoospermia factor area. Other factors include chemical or toxin exposure, previous exposure to radiation therapy, and a history of severe trauma. A ...
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Aspermia
Aspermia is the complete lack of semen with ejaculation (not to be confused with azoospermia, the lack of sperm cells in the semen). It is associated with infertility. One of the causes of aspermia is retrograde ejaculation, because of that the sperm is kept into the bladder and the final ejaculate is 0 mL. It can be brought on by excessive drug use, or as a result of prostate surgery. It can also be caused by alpha blockers such as tamsulosin and silodosin. Another cause of aspermia is ejaculatory duct obstruction, which may result in a complete lack or a very low-concentration of semen ( oligospermia), in which the semen contains only the secretion of accessory prostate glands downstream to the orifice of the ejaculatory ducts. Aspermia can be caused by androgen deficiency. This can be the result of absence of puberty, in which the prostate gland and seminal vesicles (which are the main sources of semen) remain small due to lack of androgen exposure and do not produce ...
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Anejaculation
Anejaculation is the pathological inability to ejaculate despite an erection in males, with (''orgasmic'') or without ( ''anorgasmic'') orgasm. Causes It can depend on one or more of several causes, including: * Sexual inhibition * Pharmacological inhibition. They include mostly antidepressant and antipsychotic medication, and the patients experiencing that tend to quit them
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Retrograde Ejaculation
Retrograde ejaculation occurs when semen which would be ejaculated via the urethra is redirected to the urinary bladder. Normally, the sphincter of the bladder contracts before ejaculation, inhibiting urination and preventing a reflux of semen into the bladder. The semen is forced to exit via the urethra, the path of least resistance. When the bladder sphincter does not function properly, retrograde ejaculation may occur. It can also be induced deliberately as a primitive form of male birth control (known as ''coitus saxonicus'') or as part of certain alternative medicine practices. The retrograde-ejaculated semen is excreted from the bladder during the next urination. Signs and symptoms Retrograde ejaculation is sometimes referred to as a " dry orgasm." A man may notice that no semen is produced during masturbation despite the occurrence of orgasm. Another underlying cause for this phenomenon may be ejaculatory duct obstruction. During a male orgasm, sperm are released fro ...
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Ejaculation
Ejaculation is the discharge of semen (the ''ejaculate''; normally containing sperm) from the penis through the urethra. It is the final stage and natural objective of male sexual stimulation, and an essential component of natural conception. After forming an erection, many men emit Pre-ejaculate, pre-ejaculatory fluid during stimulation prior to ejaculating. Ejaculation involves involuntary Muscle contraction, contractions of the pelvic floor and is normally linked with orgasm. It is a normal part of male Puberty, human sexual development. Ejaculation can occur spontaneously during sleep (a nocturnal emission or "wet dream") or in rare cases because of prostate, prostatic disease. ''Anejaculation'' is the condition of being unable to ejaculate. ''Painful ejaculation, Dysejaculation'' is an ejaculation that is painful or uncomfortable. Retrograde ejaculation is the backward flow of semen from the urethra into the urinary bladder, bladder. Premature ejaculation happens shortly ...
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Ejaculatory Duct Obstruction
Ejaculatory duct obstruction (EDO) is a pathological condition which is characterized by the obstruction of one or both ejaculatory ducts. Thus, the efflux of (most constituents of) semen is not possible. It can be congenital or acquired. It is a cause of male infertility and/or pelvic pain. Ejaculatory duct obstruction must not be confused with an obstruction of the vas deferens. Cause If both ejaculatory ducts are completely obstructed, affected men will demonstrate male infertility due to aspermia/ azoospermia. They will suffer from a very low volume of semen which lacks the gel-like fluid of the seminal vesicles or from no semen at all while they are able to have the sensation of an orgasm during which they will have involuntary contractions of the pelvic musculature. This is contrary to some other forms of anejaculation. In addition, it is reported to be a cause for pelvic pain, especially shortly after ejaculation. In case of proven fertility but unresolved pelvic pain, ...
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Cystic Fibrosis
Cystic fibrosis (CF) is a genetic disorder inherited in an autosomal recessive manner that impairs the normal clearance of Sputum, mucus from the lungs, which facilitates the colonization and infection of the lungs by bacteria, notably ''Staphylococcus aureus''. CF is a rare genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine. The hallmark feature of CF is the accumulation of thick mucus in different organs. Long-term issues include Shortness of breath, difficulty breathing and coughing up mucus as a result of frequent pneumonia, lung infections. Other signs and symptoms may include Sinusitis, sinus infections, failure to thrive, poor growth, Steatorrhea, fatty stool, Nail clubbing, clubbing of the fingers and toes, and infertility in most males. Different people may have different degrees of symptoms. Cystic fibrosis is inherited in an autosomal recessive manner. It is caused by the presence of mutations in both copies (alleles) ...
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Vas Deferens
The vas deferens (: vasa deferentia), ductus deferens (: ductūs deferentes), or sperm duct is part of the male reproductive system of many vertebrates. In mammals, spermatozoa are produced in the seminiferous tubules and flow into the epididymal duct. The end of the epididymis is connected to the vas deferens. The vas deferens ends with an opening into the ejaculatory duct at a point where the duct of the seminal vesicle also joins the ejaculatory duct. The vas deferens is a partially coiled tube which exits the abdominal cavity through the inguinal canal. Etymology ''Vas deferens'' is Latin, meaning "carrying-away vessel" while ''ductus deferens'', also Latin, means "carrying-away duct". Structure The human vas deferens measures 30–35 cm in length, and 2–3 mm in diameter. It is continuous proximally with the tail of the epididymis, and exhibits a tortuous, convoluted initial/proximal section (which measures 2–3 cm in length). Distally, it forms a dilated ...
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Agenesis
In medicine, agenesis () refers to the failure of an organ to develop during embryonic growth and development due to the absence of primordial tissue. Many forms of agenesis are referred to by individual names, depending on the organ affected: * Agenesis of the corpus callosum - failure of the Corpus callosum to develop *Renal agenesis - failure of one or both of the kidneys to develop * Amelia - failure of the arms or legs to develop * Penile agenesis - failure of penis to develop * Müllerian agenesis - failure of the uterus and part of the vagina to develop * Agenesis of the gallbladder - failure of the Gallbladder to develop. A person may not realize they have this condition unless they undergo surgery or medical imaging, since the gallbladder is neither externally visible nor essential. __TOC__ Eye agenesis Eye agenesis is a medical condition in which people are born with no eyes. Dental & oral agenesis * Anodontia, absence of all primary or permanent teeth. * Aglossia, ...
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ASRM
The American Society for Reproductive Medicine (ASRM) is a nonprofit, multidisciplinary organization for advancement of the science and practice of reproductive medicine. The society has its headquarters in Washington, D.C., and its administrative office in Birmingham, Alabama. An associated special interest group, the Society for Assisted Reproductive Technology (SART), maintains a national registry for tracking IVF attempts and outcomes. History and activities Founded in 1944 by a small group of fertility experts who met in Chicago, the initial name was the American Society for the Study of Sterility, changed in 1965 to American Fertility Society (AFS). The current name, American Society for Reproductive Medicine, was adopted in 1994. In 2018, ASRM created its own research institute. In 2019, it moved its headquarters to Washington, D.C., from Birmingham, Alabama. Though primarily an American organization, it had members from over 100 countries as of 2020. The society hosts ...
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