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Vijay Kumar (molecular Biologist)
Vijay Kumar (born 7 November 1954) is an Indian molecular biologist, virologist and an honorary scientist at the International Centre for Genetic Engineering and Biotechnology. Known for his research in hepatology, Kumar is an elected fellow of National Academy of Sciences, India, National Academy of Medical Sciences, and National Academy of Agricultural Sciences as well as a J. C. Bose National Fellow of the Department of Biotechnology. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards for his contributions to Medical Sciences in 1997. Biography Vijay Kumar was born on 7 November 1954 at Sasaram, a place known for its quarries, in Rohtas district in the Indian state of Bihar. His early college education was at Sahibganj College of Tilka Manjhi Bhagalpur University from where he completed his BSc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sasaram
Sasaram ()sometimes also spelled as Sahasram, is an ancient historical city and a municipal corporation region in the Rohtas district of the Bihar state in eastern India, with a history that goes to thousands of years. During the prehistoric age, Buddha walked through this way and lived for some days and then travelled to Gaya to be enlightened with verity and wisdom under the Mahabodhi tree, the city is also known as gateway of "Vihar" to visit rest "Bihar" including Gaya, Rajgriha, and Nalanda. It has also served as the capital of the Sur dynasty during Shershah Suri ruled over India in 16th Century, and was residence place sub capital of epic monarch Sahstrabahu ( Kartivirya Arjuna's ). The Rohtasgarh fort, one of the world's oldest forts, has served as the capital for several dynasties, Britishers and other rulers, including Shershah Suri and Akbar Governor King Man Singh, as well as the Shashanka and Kharvar empires. The historical fort has been linked to both pol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Council Of Scientific And Industrial Research
The Council of Scientific and Industrial Research ( IAST: ''vaigyanik tathā audyogik anusandhāna pariṣada''), abbreviated as CSIR, was established by the Government of India in September 1942 as an autonomous body that has emerged as the largest research and development organisation in India. CSIR is also among the world's largest publicly funded R&D organisation which is pioneering sustained contribution to S&T human resource development in the country. , it runs 37 laboratories/institutes, 39 outreach centres, 3 Innovation Centres and 5 units throughout the nation, with a collective staff of over 14,000, including a total of 4,600 scientists and 8,000 technical and support personnel. Although it is mainly funded by the Ministry of Science and Technology, it operates as an autonomous body through the Societies Registration Act, 1860. The research and development activities of CSIR include aerospace engineering, structural engineering, ocean sciences, life sciences a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trans-activating Domain
The transactivation domain or trans-activating domain (TAD) is a transcription factor scaffold domain which contains binding sites for other proteins such as transcription coregulators. These binding sites are frequently referred to as activation functions (AFs). TADs are named after their amino acid composition. These amino acids are either essential for the activity or simply the most abundant in the TAD. Transactivation by the Gal4 transcription factor is mediated by acidic amino acids, whereas hydrophobic residues in Gcn4 play a similar role. Hence, the TADs in Gal4 and Gcn4 are referred to as acidic or hydrophobic, respectively. In general we can distinguish four classes of TADs: * acidic domains (called also “acid blobs” or “negative noodles", rich in D and E amino acids, present in Gal4, Gcn4 and VP16). * glutamine-rich domains (contains multiple repetitions like "QQQXXXQQQ", present in SP1) * proline-rich domains (contains repetitions like "PPPXXXPPP" present i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hepatitis B Virus
''Hepatitis B virus'' (HBV) is a partially double-stranded DNA virus, a species of the genus '' Orthohepadnavirus'' and a member of the '' Hepadnaviridae'' family of viruses. This virus causes the disease hepatitis B. Disease Despite there being a vaccine to prevent Hepatitis B, HBV remains a global health problem. Hepatitis B can be acute and later become chronic, leading to other diseases and health conditions. In addition to causing hepatitis, infection with HBV can lead to cirrhosis and hepatocellular carcinoma. It has also been suggested that it may increase the risk of pancreatic cancer. Roles in disease Viral infection by ''Hepatitis B virus'' (HBV) causes many hepatocyte changes due to the direct action of a protein encoded by the virus, HBx, and to indirect changes due to a large increase in intracellular reactive oxygen species (ROS) after infection. HBx appears to dysregulate a number of cellular pathways. HBx causes dysregulation in part by binding to genomic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oncogenic
Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells. The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division. Cell division is a physiological process that occurs in almost all tissues and under a variety of circumstances. Normally, the balance between proliferation and programmed cell death, in the form of apoptosis, is maintained to ensure the integrity of tissues and organs. According to the prevailing accepted theory of carcinogenesis, the somatic mutation theory, mutations in DNA and epimutations that lead to cancer disrupt these orderly processes by interfering with the programming regulating the processes, upsetting the normal balance between proliferation and cell death. This results in uncontrolled cell division and the evolution of those cells by natural selection in the body. Only certain mutations lead to cancer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, protein or non-coding RNA, and ultimately affect a phenotype, as the final effect. These products are often proteins, but in non-protein-coding genes such as transfer RNA (tRNA) and small nuclear RNA (snRNA), the product is a functional non-coding RNA. Gene expression is summarized in the central dogma of molecular biology first formulated by Francis Crick in 1958, further developed in his 1970 article, and expanded by the subsequent discoveries of reverse transcription and RNA replication. The process of gene expression is used by all known life— eukaryotes (including multicellular organisms), prokaryotes (bacteria and archaea), and utilized by viruses—to generate the macromolecular machinery for life. In genetics, gene expression is the most fundamental level at which the genotype gives rise to the phenot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Cloning
Molecular cloning is a set of experimental methods in molecular biology that are used to assemble recombinant DNA molecules and to direct their replication within host organisms. The use of the word ''cloning'' refers to the fact that the method involves the replication of one molecule to produce a population of cells with identical DNA molecules. Molecular cloning generally uses DNA sequences from two different organisms: the species that is the source of the DNA to be cloned, and the species that will serve as the living host for replication of the recombinant DNA. Molecular cloning methods are central to many contemporary areas of modern biology and medicine. In a conventional molecular cloning experiment, the DNA to be cloned is obtained from an organism of interest, then treated with enzymes in the test tube to generate smaller DNA fragments. Subsequently, these fragments are then combined with vector DNA to generate recombinant DNA molecules. The recombinant DNA is then i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HBV Genome , a former German trade union
{{disambiguation ...
HBV may refer to: * Buskerud and Vestfold University College (Norwegian: ') * Hamengkubuwono V, 19th-century ruler of Yogyakarta, Java * ''Handbuch der Vögel Mitteleuropas'' (''Handbook of the Birds of Central Europe'') * HBV hydrology model * Hepatitis B virus * Hepatitis B vaccine * Heterostructure barrier varactor * Trade, Banking and Insurance Union The Trade, Banking and Insurance Union (german: Gewerkschaft Handel, Banken und Versicherungen, HBV) was a trade union representing workers in commerce and finance in Germany. During 1947 and 1948, German trade unionists were regrouping and the ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Strasbourg
Strasbourg (, , ; german: Straßburg ; gsw, label= Bas Rhin Alsatian, Strossburi , gsw, label= Haut Rhin Alsatian, Strossburig ) is the prefecture and largest city of the Grand Est region of eastern France and the official seat of the European Parliament. Located at the border with Germany in the historic region of Alsace, it is the prefecture of the Bas-Rhin department. In 2019, the city proper had 287,228 inhabitants and both the Eurométropole de Strasbourg (Greater Strasbourg) and the Arrondissement of Strasbourg had 505,272 inhabitants. Strasbourg's metropolitan area had a population of 846,450 in 2018, making it the eighth-largest metro area in France and home to 14% of the Grand Est region's inhabitants. The transnational Eurodistrict Strasbourg-Ortenau had a population of 958,421 inhabitants. Strasbourg is one of the ''de facto'' four main capitals of the European Union (alongside Brussels, Luxembourg and Frankfurt), as it is the seat of several European ins ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lady Tata Memorial Trust
Lady Tata Memorial Trust is a philanthropic body established by Sir Dorabji Tata in April 1932 in memory of his wife, Lady Meherbai, who was diagnosed with leukemia in 1930 at the age of 50, and succumbed to the disease on 18 June 1931. The Trust spends its income for supporting research, both international and Indian, on leukemia. Four-fifth of the income of the Trust is spent on supporting international research. The international awards are restricted to research on leukaemogenic agents, and the epidemiology, pathogenesis, immunology Immunology is a branch of medicineImmunology for Medical Students, Roderick Nairn, Matthew Helbert, Mosby, 2007 and biology that covers the medical study of immune systems in humans, animals, plants and sapient species. In such we can see the ... and genetic basis of leukaemia and related disorders. One-fifth of the income is spent for supporting scholars working in Indian universities and institutes. The Indian awards are offered as Post-Doc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
All India Institute Of Medical Sciences, Delhi
All India Institute of Medical Sciences, New Delhi, also known as AIIMS Delhi, is a public medical research university and hospital in New Delhi, India. The institute is governed by the AIIMS Act, 1956 and operates autonomously under the Ministry of Health and Family Welfare (India), Ministry of Health and Family Welfare. History The idea of AIIMS arose in 1946, after a recommendation by the Health Survey of the Government of India. From then to the establishment and development of AIIMS (New Delhi) over the ensuing years, several illustrious individuals played their part in bringing the idea to fruition. Originally proposed by the then Prime Minister of India Jawaharlal Nehru for establishment in Calcutta, it was established in New Delhi following the refusal of Chief Minister of West Bengal Bidhan Chandra Roy. The foundation stone of AIIMS Delhi was laid in 1952. On February 18, 1956, the then Minister of Health, Rajkumari Amrit Kaur, introduced a new bill in the Lok Sabha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rohtas District
Rohtas District is one of the thirty-eight districts of Bihar state, India. It came into existence when Shahabad District was bifurcated into Bhojpur & Rohtas in 1972. Administrative headquarter of the district is Sasaram. Rohtas district has the highest literacy in Bihar. The literacy rate of Rohtas district which is 73.37% as per 2011 census is highest among all 38 districts of Bihar. Rohtas district also has one of the highest forest cover among all 38 districts of Bihar. The Rohtas district is a part of Patna Division, and it has an area of 3850 km², a population of 2,959,918 (2011 census), and a population density of 763 persons per km². Languages spoken here are Bhojpuri, Hindi and English. History Rohtas district was created in 1972, when the former Shahabad district was divided in two. It corresponded to the former district's sub-divisions of Sasaram and Bhabua. In 1991, Bhabua was split off as a separate district, which was renamed Kaimur district in 1994. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
