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UCL Institute Of Neurology
The UCL Queen Square Institute of Neurology is an institute within the Faculty of Brain Sciences of University College London (UCL) and is located in London, United Kingdom. Together with the National Hospital for Neurology and Neurosurgery, an adjacent facility with which it cooperates closely, the institute forms a major centre for teaching, training and research in neurology and allied clinical and basic neurosciences. The institute has a staff of around 710 and 500 graduate students, an annual turnover of £81million and occupies around 12,000 sq m of laboratory and office space. Four of the 12 most highly cited authors in neuroscience and behaviour in the world are currently based at the institute. The institute conducts research into a wide range of neurological diseases, including movement disorders, multiple sclerosis, epilepsy, brain cancer, stroke and brain injury, muscle and nerve disorders, cognitive dysfunction and dementia. It forms a key part of UCL Neuroscien ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Hospital For Neurology And Neurosurgery
The National Hospital for Neurology and Neurosurgery (informally the National Hospital or Queen Square) is a neurological hospital in Queen Square, London. It is part of the University College London Hospitals NHS Foundation Trust. It was the first hospital to be established in England dedicated exclusively to treating the diseases of the nervous system. It is closely associated with University College London (UCL) and in partnership with the UCL Institute of Neurology, which occupies the same site, is a major centre for neuroscience research. History The hospital was founded by Johanna Chandler as the National Hospital for the Paralysed and Epileptic at Queen Square in 1859. The hospital was completely rebuilt in the early 1880s: the East Wing was re-opened by Princess Helena in 1881 and the West Wing was re-opened by the Prince of Wales in 1885. In 1904, it adopted the name National Hospital for the Relief and Cure of the Paralysed and Epileptic. The hospital served as a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Down's Syndrome
Down syndrome or Down's syndrome, also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. It is usually associated with physical growth delays, mild to moderate intellectual disability, and characteristic facial features. The average IQ of a young adult with Down syndrome is 50, equivalent to the mental ability of an eight- or nine-year-old child, but this can vary widely. The parents of the affected individual are usually genetically normal. The probability increases from less than 0.1% in 20-year-old mothers to 3% in those of age 45. The extra chromosome is believed to occur by chance, with no known behavioral activity or environmental factor that changes the probability. Down syndrome can be identified during pregnancy by prenatal screening followed by diagnostic testing or after birth by direct observation and genetic testing. Since the introduction of screening, Down syndrome pregnancies are often aborte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elizabeth Fisher (neuroscientist)
Elizabeth Mary Claire Fisher is a British geneticist and Professor at University College London. Her research investigates the degeneration of motor neurons during amyotrophic lateral sclerosis and Alzheimer's disease triggered by Down syndrome. Education Fisher studied physiological sciences at the University of Oxford where she was an undergraduate student at St Anne's College, Oxford in 1981. After completing her undergraduate studies Fisher left science and trained as a typist and worked in several different jobs in UK and Australia and in 1983 moved to Imperial College London, where she worked on mouse molecular genetics. At St Mary's Hospital, London Fisher completed microdissection on the mouse X chromosome. During her doctoral research she worked alongside Mary F. Lyon and Stephen Brown at the Medical Research Council in Harwell. She dissected individual chromosomes and cloned DNA fragments into plasmids. Career and research After graduating from Imperial C ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wellcome Trust
The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of GlaxoSmithKline) to fund research to improve human and animal health. The aim of the Trust is to "support science to solve the urgent health challenges facing everyone." It had a financial endowment of £29.1 billion in 2020, making it the fourth wealthiest charitable foundation in the world. In 2012, the Wellcome Trust was described by the ''Financial Times'' as the United Kingdom's largest provider of non-governmental funding for scientific research, and one of the largest providers in the world. According to their annual report, the Wellcome Trust spent GBP £1.1Bn on charitable activities across their 2019/2020 financial year. According to the OECD, the Wellcome Trust's financing for 2019 development increased by 22% to US$327 millio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Variant CJD
Variant may refer to: In arts and entertainment * ''Variant'' (magazine), a former British cultural magazine * Variant cover, an issue of comic books with varying cover art * ''Variant'' (novel), a novel by Robison Wells * " The Variant", 2021 episode of the TV series ''Loki'' **Sylvie (Marvel Cinematic Universe), a character who was originally referred to as the Variant In gaming * Chess variant, a game derived from, related to or similar to chess in at least one respect *List of poker variants * List of ''Tetris'' variants In mathematics and computing * Variant (logic), a term or formula obtained from another one by consistently renaming all variables * Variant symlinks, a symbolic link to a file that has a variable name embedded in it *Variant type, in programming languages * Z-variant, unicode characters that share the same etymology but have slightly different appearances Computer security * In network security, varieties of computer worms are called variants. In biol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bovine Spongiform Encephalopathy
Bovine spongiform encephalopathy (BSE), commonly known as mad cow disease, is an incurable and invariably fatal neurodegenerative disease of cattle. Symptoms include abnormal behavior, trouble walking, and weight loss. Later in the course of the disease the cow becomes unable to function normally. There is conflicting information around the time between infection and onset of symptoms. In 2002, the WHO suggested it to be approximately four to five years. Time from onset of symptoms to death is generally weeks to months. Spread to humans is believed to result in variant Creutzfeldt–Jakob disease (vCJD). As of 2018, a total of 231 cases of vCJD had been reported globally. BSE is thought to be due to an infection by a misfolded protein, known as a prion. Cattle are believed to have been infected by being fed meat-and-bone meal (MBM) that contained either the remains of cattle who spontaneously developed the disease or scrapie-infected sheep products. The outbreak increased t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wellcome Centre For Human Neuroimaging
The 'Wellcome Centre for Human Neuroimaging'' at University College London is a world-leading interdisciplinary centre for neuroimaging research based in London, United Kingdom. Researchers at the Centre use expertise to investigate how the human brain generates behaviour, thoughts and feelings and how to use this knowledge to help patients with neurological and psychiatric disorders. Human neuroimaging allows scientists to non-invasively investigate the brain structure and functions including Action, Decision Making, Emotion, Hearing, Language, Memory, Navigation, Seeing, Self awareness, Social Behaviour and the Bayesian Brain The Wellcome Centre for Human Neuroimaging is part of UCL'Department for Imaging Neuroscience alongsidThe Max Planck UCL Centre for Computational Psychiatry and Ageingand Affiliated Principal Investigators (PIs). The current team of researchers and support staff use their diverse and interdisciplinary skills to work collaboratively towards one shared go ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuroinflammation
Neuroinflammation is inflammation of the nervous tissue. It may be initiated in response to a variety of cues, including infection, traumatic brain injury,Ebert SE, Jensen P, Ozenne B, Armand S, Svarer C, Stenbaek DS ''et al.'' Molecular imaging of neuroinflammation in patients after mild traumatic brain injury: a longitudinal 123 I-CLINDE SPECT study. ''Eur J Neurol'' 2019. doi:10.1111/ene.13971. toxic metabolites, or autoimmunity. In the central nervous system (CNS), including the brain and spinal cord, microglia are the resident innate immune cells that are activated in response to these cues. The CNS is typically an immunologically privileged site because peripheral immune cells are generally blocked by the blood–brain barrier (BBB), a specialized structure composed of astrocytes and endothelial cells. However, circulating peripheral immune cells may surpass a compromised BBB and encounter neurons and glial cells expressing major histocompatibility complex molecules, perpet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Huntington's Disease
Huntington's disease (HD), also known as Huntington's chorea, is a neurodegenerative disease that is mostly inherited. The earliest symptoms are often subtle problems with mood or mental abilities. A general lack of coordination and an unsteady gait often follow. It is also a basal ganglia disease causing a hyperkinetic movement disorder known as chorea. As the disease advances, uncoordinated, involuntary body movements of chorea become more apparent. Physical abilities gradually worsen until coordinated movement becomes difficult and the person is unable to talk. Mental abilities generally decline into dementia. The specific symptoms vary somewhat between people. Symptoms usually begin between 30 and 50 years of age but can start at any age. The disease may develop earlier in each successive generation. About eight percent of cases start before the age of 20 years, and are known as ''juvenile HD'', which typically present with the slow movement symptoms of Parkinson's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurodegeneration
A neurodegenerative disease is caused by the progressive loss of structure or function of neurons, in the process known as neurodegeneration. Such neuronal damage may ultimately involve cell death. Neurodegenerative diseases include amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's disease, Huntington's disease, multiple system atrophy, and prion diseases. Neurodegeneration can be found in the brain at many different levels of neuronal circuitry, ranging from molecular to systemic. Because there is no known way to reverse the progressive degeneration of neurons, these diseases are considered to be incurable; however research has shown that the two major contributing factors to neurodegeneration are oxidative stress and inflammation. Biomedical research has revealed many similarities between these diseases at the subcellular level, including atypical protein assemblies (like proteinopathy) and induced cell death. These similarities suggest t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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