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Substituted Mescaline Analogue
A substituted mescaline analogue, also known as a scaline and typically but not always a 4-substituted 3,5-dimethoxyphenethylamine, is an structural analog, analogue of the substituted phenethylamine, phenethylamine serotonergic psychedelic mescaline (3,4,5-trimethoxyphenethylamine). Other related compounds include the 2C (psychedelics), 2C (4-substituted 2,5-dimethoxyphenethylamine) and DOx (4-substituted 2,5-dimethoxyamphetamine) chemical compound, compounds as well as 3,4,5-trimethoxyamphetamine (TMA) and other 4-substituted 3,5-dimethoxyamphetamines (3C drugs). They are also mescaline analogues, but the 2C and DOx drugs have a third methoxy group in the 2 position instead of the 3 position while TMA is an substituted amphetamine, amphetamine rather than a phenethylamine. The pharmacology of mescaline analogues has been studied. Mescaline analogues, or 4-substituted 3,5-dimethoxyphenethylamines specifically, tend to be much less potency (pharmacology), potent than the 2C and DO ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mescaline Structural Formulae Bondline
Mescaline or mescalin (3,4,5-trimethoxyphenethylamine) is a natural product, naturally occurring psychedelic drug, psychedelic alkaloid, protoalkaloid of the substituted phenethylamine class, known for its hallucinogenic effects comparable to those of lysergic acid diethylamide, LSD and psilocybin. Biological sources It occurs naturally in several species of Psychoactive cactus, cacti. It is also found in small amounts in certain members of the bean family, Fabaceae, including ''Acacia berlandieri''. However those claims concerning ''Acacia'' species have been challenged and have been unsupported in any additional analysis. History and use Peyote has been used for at least 5,700 years by Indigenous peoples of the Americas in Mexico. Europeans noted use of peyote in Native American religious ceremonies upon early contact, notably by the Huichol people, Huichols in Mexico. Other mescaline-containing cacti such as the San Pedro have a long history of use in South America, from ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4-Desoxymescaline
4-Desoxymescaline, or 4-methyl-3,5-dimethoxyphenethylamine, is a mescaline analogue related to other psychedelic phenethylamines. It is commonly referred to as DESOXY. DESOXY was discovered by Alexander Shulgin and published in his book '' PiHKAL''. Effects The effects of DESOXY vary significantly from mescaline, despite their chemical similarity. Dosage A typical dosage is within the range of 40–120 mg and lasts 6–8 hours. Legality In 1970 the Controlled Substances Act placed mescaline into Schedule I in the United States. It is similarly controlled in other nations. Depending on whether or not it is intended for human consumption, 4-desoxymescaline could be considered an analogue of mescaline, under the Federal Analogue Act and similar bills in other countries, making it illegal to manufacture, buy, possess, or distribute without a DEA or related license. DESOXY is also an isomer of 2C-D which makes it a schedule 1 drug in the United States. References ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyclopropylmescaline
Cyclopropylmescaline (CPM or 4-cyclopropylmethoxy-3,5-dimethoxyphenethylamine) is a lesser-known psychedelic drug. CPM was first synthesized by Alexander Shulgin. In his book '' PiHKAL'', the dosage range is listed as 60–80 mg and the duration listed as 12–18 hours. CPM produces closed-eye imagery, visuals, and fantasies. It also causes enhancement of music. Very little data exists about the pharmacological properties, metabolism, and toxicity of CPM. See also * Phenethylamine * Psychedelics, dissociatives and deliriants Hallucinogens are a large, diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mood, and perception as well as other changes. Most hallucinogens can be categorized ... References Psychedelic phenethylamines Mescalines Cyclopropyl compounds {{hallucinogen-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Buscaline
Buscaline (3,5-dimethoxy-4-butoxyphenethylamine) is a chemical compound prepared as a possible psychedelic drug. It is an analog of mescaline. Buscaline was first synthesized by Alexander Shulgin. In his book '' PiHKAL'', the minimum dosage is listed as 150 mg, and the duration is "several hours". Buscaline produces no psychedelic or psychoactive effects, but causes heart arrythmia and light diarrhea. It does not cause any visuals or insights. Very little data exists about the pharmacological properties, metabolism, and toxicity of buscaline. See also * Phenethylamine Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans. In the brain, phenethylamine regulates monoamine neurotransmission by binding to trace amin ... References Phenethylamines Pyrogallol ethers {{Psychoactive-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biscaline
Biscaline, also known as 3,5-dimethoxy-4-phenylphenethylamine, is a monoamine receptor modulator of the phenethylamine family. It is the analogue of mescaline (3,4,5-dimethoxyphenethylamine) in which the methoxy group at the 4 position has been replaced with a phenyl ring. The drug shows affinity for the serotonin 5-HT1A receptor (Ki = 4,021nM). Conversely, it did not bind to the serotonin 5-HT2A, 5-HT2B, or 5-HT2C receptors at the assessed concentrations (Ki = >13,400nM, >10,000nM, and >14,590nM, respectively). It is said to have lacked activational effects on the serotonin 5-HT2A and 5-HT2B receptors at the assessed concentrations. Biscaline also bound to the α2A-adrenergic receptor (Ki = 797nM), but not to the α1A-adrenergic receptor, the dopamine D2 receptor, or the monoamine transporters (, , or ) at the assessed concentrations (Ki = >7,510–10,550nM). It was a very weak monoamine reuptake inhibitor, with values of 457,000nM for serotonin, 160,000nM for norepine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benzscaline
Benzscaline (BZ), also known as 4-benzyloxy-3,5-dimethoxyphenethylamine (4-BzlO-3,5-DMPEA), is a serotonin receptor agonist and possible serotonergic psychedelic of the substituted phenethylamine, phenethylamine and substituted mescaline analogue, scaline families. It is a potency (pharmacology), potent serotonin 5-HT2A receptor, 5-HT2A receptor partial agonist, with an affinity (pharmacology), affinity (Ki) of 150nM, an receptor activation, activational potency (pharmacology), potency () of 27nM, and an maximal efficacy, efficacy () of 77%. Its affinity and activational potency were 63- and 370-fold more potent than those of mescaline, respectively, and it was the most potent assessed mescaline analogue. In addition, benzscaline was more efficacious in activating the receptor than mescaline ( = 56% vs. 77%, respectively). Benzscaline does not activate the serotonin 5-HT2B receptor, 5-HT2B receptor ( = >10,000nM), but does show affinity for the serotonin 5-HT2C receptor, 5-HT2C re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Allylescaline
Allylescaline (4-allyloxy-3,5-dimethoxyphenethylamine) is a lesser-known psychedelic drug. It is closely related in structure to mescaline. Allylescaline was first synthesized by Otakar Leminger in 1972. The compound was later synthesized by Alexander Shulgin and further described in his book '' PiHKAL''. The dosage range is listed as 20–35 mg, and the duration 8–12 hours. Allylescaline produces an entactogenic warmth, an entheogenic effect, and a feeling of flowing energy. Very little data exists about the pharmacological properties, metabolism, and toxicity of allylescaline. Legal status Allylescaline is illegal in Sweden as of January 2016. See also * Proscaline * Phenethylamine * Psychedelics, dissociatives and deliriants * Substituted phenethylamine * Elemicin Elemicin is a phenylpropene, a natural organic compound, and is a constituent of several plant species' essential oils. Natural occurrence Elemicin is a constituent of the oleoresin and the essent ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
