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Receptive Field
The receptive field, or sensory space, is a delimited medium where some physiological stimuli can evoke a sensory neuronal response in specific organisms. Complexity of the receptive field ranges from the unidimensional chemical structure of odorants to the multidimensional spacetime of human visual field, through the bidimensional skin surface, being a receptive field for touch perception. Receptive fields can positively or negatively alter the membrane potential with or without affecting the rate of action potentials. A sensory space can be dependent of an animal's location. For a particular sound wave traveling in an appropriate transmission medium, by means of sound localization, an auditory space would amount to a reference system that continuously shifts as the animal moves (taking into consideration the space inside the ears as well). Conversely, receptive fields can be largely independent of the animal's location, as in the case of place cells. A sensory space can als ...
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Stimulus (physiology)
In physiology, a stimulus is a detectable change in the physical or chemical structure of an organism's internal or external environment. The ability of an organism or organ to detect external stimuli, so that an appropriate reaction can be made, is called sensitivity (excitability). Sensory receptors can receive information from outside the body, as in touch receptors found in the skin or light receptors in the eye, as well as from inside the body, as in chemoreceptors and mechanoreceptors. When a stimulus is detected by a sensory receptor, it can elicit a reflex via stimulus transduction. An internal stimulus is often the first component of a homeostatic control system. External stimuli are capable of producing systemic responses throughout the body, as in the fight-or-flight response. In order for a stimulus to be detected with high probability, its level of strength must exceed the absolute threshold; if a signal does reach threshold, the information is transmitted to t ...
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Somatosensory System
In physiology, the somatosensory system is the network of neural structures in the brain and body that produce the perception of touch (haptic perception), as well as temperature (thermoception), body position (proprioception), and pain. It is a subset of the sensory nervous system, which also represents visual, auditory, olfactory, and gustatory stimuli. Somatosensation begins when mechano- and thermosensitive structures in the skin or internal organs sense physical stimuli such as pressure on the skin (see mechanotransduction, nociception). Activation of these structures, or receptors, leads to activation of peripheral sensory neurons that convey signals to the spinal cord as patterns of action potentials. Sensory information is then processed locally in the spinal cord to drive reflexes, and is also conveyed to the brain for conscious perception of touch and proprioception. Note, somatosensory information from the face and head enters the brain through periphera ...
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Spectrogram
A spectrogram is a visual representation of the spectrum of frequencies of a signal as it varies with time. When applied to an audio signal, spectrograms are sometimes called sonographs, voiceprints, or voicegrams. When the data are represented in a 3D plot they may be called '' waterfall displays''. Spectrograms are used extensively in the fields of music, linguistics, sonar, radar, speech processing, seismology, and others. Spectrograms of audio can be used to identify spoken words phonetically, and to analyse the various calls of animals. A spectrogram can be generated by an optical spectrometer, a bank of band-pass filters, by Fourier transform or by a wavelet transform (in which case it is also known as a scaleogram or scalogram). A spectrogram is usually depicted as a heat map, i.e., as an image with the intensity shown by varying the colour or brightness. Format A common format is a graph with two geometric dimensions: one axis represents time, and the other ...
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Spectro-temporal Receptive Field
The spectro-temporal receptive field or spatio-temporal receptive field (STRF) of a neuron represents which types of stimuli excite or inhibit that neuron. "Spectro-temporal" refers most commonly to audition, where the neuron's response depends on frequency versus time, while "spatio-temporal" refers to vision, where the neuron's response depends on spatial location versus time. Thus they are not exactly the same concept, but both are referred to as STRF and serve a similar role in the analysis of neural responses. If linearity is assumed, the neuron can be modeled as having a time-varying firing rate equal to the convolution of the stimulus with the STRF. Auditory STRFs The example STRF here is for an auditory neuron from the area CM (caudal medial) of a male zebra finch, when played conspecific Biological specificity is the tendency of a characteristic such as a behavior or a biochemical variation to occur in a particular species. Biochemist Linus Pauling stated that "Biologic ...
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Deep Neural Networks
Deep learning (also known as deep structured learning) is part of a broader family of machine learning methods based on artificial neural networks with representation learning. Learning can be supervised, semi-supervised or unsupervised. Deep-learning architectures such as deep neural networks, deep belief networks, deep reinforcement learning, recurrent neural networks, convolutional neural networks and Transformers have been applied to fields including computer vision, speech recognition, natural language processing, machine translation, bioinformatics, drug design, medical image analysis, climate science, material inspection and board game programs, where they have produced results comparable to and in some cases surpassing human expert performance. Artificial neural networks (ANNs) were inspired by information processing and distributed communication nodes in biological systems. ANNs have various differences from biological brains. Specifically, artificial neural ...
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Photoreceptor Cell
A photoreceptor cell is a specialized type of neuroepithelial cell found in the retina that is capable of visual phototransduction. The great biological importance of photoreceptors is that they convert light (visible electromagnetic radiation) into signals that can stimulate biological processes. To be more specific, photoreceptor proteins in the cell absorb photons, triggering a change in the cell's membrane potential. There are currently three known types of photoreceptor cells in mammalian eyes: rods, cones, and intrinsically photosensitive retinal ganglion cells. The two classic photoreceptor cells are rods and cones, each contributing information used by the visual system to form an image of the environment, sight. Rods primarily mediate scotopic vision (dim conditions) whereas cones primarily mediate to photopic vision (bright conditions), but the processes in each that supports phototransduction is similar. A third class of mammalian photoreceptor cell was di ...
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Retinal Ganglion Cell
A retinal ganglion cell (RGC) is a type of neuron located near the inner surface (the ganglion cell layer) of the retina of the eye. It receives visual information from photoreceptors via two intermediate neuron types: bipolar cells and retina amacrine cells. Retina amacrine cells, particularly narrow field cells, are important for creating functional subunits within the ganglion cell layer and making it so that ganglion cells can observe a small dot moving a small distance. Retinal ganglion cells collectively transmit image-forming and non-image forming visual information from the retina in the form of action potential to several regions in the thalamus, hypothalamus, and mesencephalon, or midbrain. Retinal ganglion cells vary significantly in terms of their size, connections, and responses to visual stimulation but they all share the defining property of having a long axon that extends into the brain. These axons form the optic nerve, optic chiasm, and optic tract. A s ...
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Cell (biology)
The cell is the basic structural and functional unit of life forms. Every cell consists of a cytoplasm enclosed within a membrane, and contains many biomolecules such as proteins, DNA and RNA, as well as many small molecules of nutrients and metabolites.Cell Movements and the Shaping of the Vertebrate Body
in Chapter 21 of
Molecular Biology of the Cell
'' fourth edition, edited by Bruce Alberts (2002) published by Garland Science. The Alberts text discusses how the "cellular building blocks" move to shape developing embryos. It is also common to describe small molecules such as ...
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Synapses
In the nervous system, a synapse is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron or to the target effector cell. Synapses are essential to the transmission of nervous impulses from one neuron to another. Neurons are specialized to pass signals to individual target cells, and synapses are the means by which they do so. At a synapse, the plasma membrane of the signal-passing neuron (the ''presynaptic'' neuron) comes into close apposition with the membrane of the target (''postsynaptic'') cell. Both the presynaptic and postsynaptic sites contain extensive arrays of molecular machinery that link the two membranes together and carry out the signaling process. In many synapses, the presynaptic part is located on an axon and the postsynaptic part is located on a dendrite or soma. Astrocytes also exchange information with the synaptic neurons, responding to synaptic activity and, in turn, regulating neurotransmission. Sy ...
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Retina
The retina (from la, rete "net") is the innermost, light-sensitive layer of tissue of the eye of most vertebrates and some molluscs. The optics of the eye create a focused two-dimensional image of the visual world on the retina, which then processes that image within the retina and sends nerve impulses along the optic nerve to the visual cortex to create visual perception. The retina serves a function which is in many ways analogous to that of the film or image sensor in a camera. The neural retina consists of several layers of neurons interconnected by synapses and is supported by an outer layer of pigmented epithelial cells. The primary light-sensing cells in the retina are the photoreceptor cells, which are of two types: rods and cones. Rods function mainly in dim light and provide monochromatic vision. Cones function in well-lit conditions and are responsible for the perception of colour through the use of a range of opsins, as well as high-acuity vision used fo ...
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Frog
A frog is any member of a diverse and largely carnivorous group of short-bodied, tailless amphibians composing the order Anura (ανοὐρά, literally ''without tail'' in Ancient Greek). The oldest fossil "proto-frog" ''Triadobatrachus'' is known from the Early Triassic of Madagascar, but molecular clock dating suggests their split from other amphibians may extend further back to the Permian, 265 million years ago. Frogs are widely distributed, ranging from the tropics to subarctic regions, but the greatest concentration of species diversity is in tropical rainforest. Frogs account for around 88% of extant amphibian species. They are also one of the five most diverse vertebrate orders. Warty frog species tend to be called toads, but the distinction between frogs and toads is informal, not from taxonomy or evolutionary history. An adult frog has a stout body, protruding eyes, anteriorly-attached tongue, limbs folded underneath, and no tail (the tail of tailed frogs is an ext ...
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Haldan Keffer Hartline
Haldan Keffer Hartline (December 22, 1903 – March 17, 1983) was an American physiologist who was a co-recipient (with George Wald and Ragnar Granit) of the 1967 Nobel Prize in Physiology or Medicine for his work in analyzing the neurophysiological mechanisms of vision. Education Hartline did his undergraduate studies at Lafayette College in Easton, Pennsylvania, graduating in 1923. He began his study of retinal electrophysiology as a National Research Council Fellow at Johns Hopkins School of Medicine, receiving his medical degree in 1927. Career and research After attending the universities of Leipzig and Munich as an Eldridge Johnson traveling research scholar from the University of Pennsylvania, he returned to the US to take a position in the Eldridge Reeves Johnson Foundation for Medical Physics at Penn, which was under the directorship of Detlev W. Bronk at that time. In 1940–1941, he was Associate Professor of Physiology at Cornell Medical College in New York City, but ...
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