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Rabbit Test
The rabbit test, or Friedman test, was an early pregnancy test developed in 1931 by Maurice Friedman and Maxwell Edward Lapham at the University of Pennsylvania. Test The hormone human chorionic gonadotropin (hCG) is produced during pregnancy and can be found in a pregnant woman's urine and blood; it indicates the presence of an implanted fertilized egg. An earlier test, known as the AZ test, was developed by Selmar Aschheim and Bernhard Zondek. When urine from a woman in the early months of pregnancy was injected into immature female mice, their ovaries would enlarge and show follicular maturation. The test was considered reliable, with an error rate of less than 2%. Friedman and Lapham's test was essentially identical, but replaced the mouse with a rabbit. A few days after the injection, the animal would be dissected and the size of her ovaries examined. The rabbit test became a widely used bioassay (animal-based test) to test for pregnancy. The term "rabbit test" wa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pregnancy Test
A pregnancy test is used to determine whether a female is pregnant or not. The two primary methods are testing for the female pregnancy hormone (human chorionic gonadotropin (hCG)) in blood or urine using a pregnancy test kit, and scanning with ultrasonography. Testing blood for hCG results in the earliest detection of pregnancy. Almost all pregnant women will have a positive urine pregnancy test one week after the first day of a missed menstrual period. Types Human chorionic gonadotropin (hCG) Identified in the early 20th century, human chorionic gonadotropin (hCG) is a glycoprotein hormone that rises quickly in the first few weeks of pregnancy, typically reaching a peak at 8- to 10-weeks gestational age. hCG is produced by what will become the placenta. hCG testing can be performed with a blood (serum) sample (typically done in a medical facility) or with urine (which can be performed in a medical facility or at home). The assays used to detect the presence of hCG in b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ovarian Follicle
An ovarian follicle is a roughly spheroid cellular aggregation set found in the ovaries. It secretes hormones that influence stages of the menstrual cycle. At the time of puberty, women have approximately 200,000 to 300,000 follicles, each with the potential to release an egg cell (ovum) at ovulation for fertilization. These eggs are developed once every menstrual cycle with around 450–500 being ovulated during a woman's reproductive lifetime. Structure Ovarian follicles are the basic units of female reproductive biology. Each of them contains a single oocyte (immature ovum or egg cell). These structures are periodically initiated to grow and develop, culminating in ovulation of usually a single competent oocyte in humans. They also consist of granulosa cells and theca of follicle. Oocyte Once a month, one of the ovaries releases a mature egg (ovum), known as an oocyte. The nucleus of such an oocyte is called a '' germinal vesicle (see picture).'' Cumulus oophorus C ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Urban Legends Reference Pages
''Snopes'' , formerly known as the ''Urban Legends Reference Pages'', is a fact-checking website. It has been described as a "well-regarded reference for sorting out myths and rumors" on the Internet. The site has also been seen as a source for both validating and debunking urban legends and similar stories in American popular culture. History 1990s In 1994, David and Barbara Mikkelson created an urban folklore web site that would become ''Snopes.com''. ''Snopes'' was an early online encyclopedia focused on urban legends, which mainly presented search results of user discussions. The site grew to encompass a wide range of subjects and became a resource to which Internet users began submitting pictures and stories of questionable veracity. According to the Mikkelsons, ''Snopes'' predated the search engine concept of fact-checking via search results. David Mikkelson had originally adopted the username "Snopes" (the name of a family of often unpleasant people in the works of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
African Clawed Frog
The African clawed frog (''Xenopus laevis'', also known as the xenopus, African clawed toad, African claw-toed frog or the ''platanna'') is a species of African aquatic frog of the family Pipidae. Its name is derived from the three short claws on each hind foot, which it uses to tear apart its food. The word ''Xenopus'' means 'strange foot' and ''laevis'' means 'smooth'. The species is found throughout much of Sub-Saharan Africa (Nigeria and Sudan to South Africa),Weldon; du Preez; Hyatt; Muller; and Speare (2004). Origin of the Amphibian Chytrid Fungus.' Emerging Infectious Diseases 10(12). and in isolated, introduced populations in North America, South America, Europe, and Asia. All species of the family Pipidae are tongueless, toothless and completely aquatic. They use their hands to shove food in their mouths and down their throats and a hyobranchial pump to draw or suck things in their mouth. Pipidae have powerful legs for swimming and lunging after food. They also use the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lancelot Hogben
Lancelot Thomas Hogben FRS FRSE (9 December 1895 – 22 August 1975) was a British experimental zoologist and medical statistician. He developed the African clawed frog ''(Xenopus laevis)'' as a model organism for biological research in his early career, attacked the eugenics movement in the middle of his career, and popularised books on science, mathematics and language in his later career. Early life and education Hogben was born and raised in Southsea near Portsmouth in Hampshire. His parents were Methodists. He attended Tottenham County School in London, his family having moved to Stoke Newington, where his mother had grown up, in 1907, and then as a medical student studied physiology at Trinity College, Cambridge. Hogben had matriculated into the University of London as an external student before he could apply to Cambridge and he graduated as a Bachelor of Science (BSc) in 1914. He took his Cambridge degree in 1915, graduating with an Ordinary BA. He had acquired sociali ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bioassay
A bioassay is an analytical method to determine the concentration or potency of a substance by its effect on living animals or plants (''in vivo''), or on living cells or tissues(''in vitro''). A bioassay can be either quantal or quantitative, direct or indirect. If the measured response is binary, the assay is quantal, if not, it is quantitative. A bioassay may be used to detect biological hazards or to give an assessment of the quality of a mixture. A bioassay is often used to monitor water quality as well as wastewater discharges and its impact on the surroundings. It is also used to assess the environmental impact and safety of new technologies and facilities. Principle A bioassay is a biochemical test to estimate the potency of a sample compound. Usually this potency can only be measured relative to a standard compound. A typical bioassay involves a ''stimulus'' (ex. drugs) applied to a ''subject'' (ex. animals, tissues, plants). The corresponding ''response'' (ex. death ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dissection
Dissection (from Latin ' "to cut to pieces"; also called anatomization) is the dismembering of the body of a deceased animal or plant to study its anatomical structure. Autopsy is used in pathology and forensic medicine to determine the cause of death in humans. Less extensive dissection of plants and smaller animals preserved in a formaldehyde solution is typically carried out or demonstrated in biology and natural science classes in middle school and high school, while extensive dissections of cadavers of adults and children, both fresh and preserved are carried out by medical students in medical schools as a part of the teaching in subjects such as anatomy, pathology and forensic medicine. Consequently, dissection is typically conducted in a morgue or in an anatomy lab. Dissection has been used for centuries to explore anatomy. Objections to the use of cadavers have led to the use of alternatives including virtual dissection of computer models. Overview Plant and animal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rabbit
Rabbits, also known as bunnies or bunny rabbits, are small mammals in the family Leporidae (which also contains the hares) of the order Lagomorpha (which also contains the pikas). ''Oryctolagus cuniculus'' includes the European rabbit species and its descendants, the world's 305 breeds of domestic rabbit. ''Sylvilagus'' includes 13 wild rabbit species, among them the seven types of cottontail. The European rabbit, which has been introduced on every continent except Antarctica, is familiar throughout the world as a wild prey animal and as a domesticated form of livestock and pet. With its widespread effect on ecologies and cultures, the rabbit is, in many areas of the world, a part of daily life—as food, clothing, a companion, and a source of artistic inspiration. Although once considered rodents, lagomorphs like rabbits have been discovered to have diverged separately and earlier than their rodent cousins and have a number of traits rodents lack, like two extra i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Developmental Biology
Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of regeneration, asexual reproduction, metamorphosis, and the growth and differentiation of stem cells in the adult organism. Perspectives The main processes involved in the embryonic development of animals are: tissue patterning (via regional specification and patterned cell differentiation); tissue growth; and tissue morphogenesis. * Regional specification refers to the processes that create the spatial patterns in a ball or sheet of initially similar cells. This generally involves the action of cytoplasmic determinants, located within parts of the fertilized egg, and of inductive signals emitted from signaling centers in the embryo. The early stages of regional specification do not generate functional differentiated cells, but cell populations committed to developing to a specific region or part of the organism. These a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ovaries
The ovary is an organ in the female reproductive system that produces an ovum. When released, this travels down the fallopian tube into the uterus, where it may become fertilized by a sperm. There is an ovary () found on each side of the body. The ovaries also secrete hormones that play a role in the menstrual cycle and fertility. The ovary progresses through many stages beginning in the prenatal period through menopause. It is also an endocrine gland because of the various hormones that it secretes. Structure The ovaries are considered the female gonads. Each ovary is whitish in color and located alongside the lateral wall of the uterus in a region called the ovarian fossa. The ovarian fossa is the region that is bounded by the external iliac artery and in front of the ureter and the internal iliac artery. This area is about 4 cm x 3 cm x 2 cm in size.Daftary, Shirish; Chakravarti, Sudip (2011). Manual of Obstetrics, 3rd Edition. Elsevier. pp. 1-16. . The ovari ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maurice Friedman
Maurice Harold Friedman (October 27, 1903 – March 8, 1991) was an American physician and reproductive-physiology researcher. He is known for the development of the rabbit test, a pregnancy test developed in 1931 while he was teaching at the Perelman School of Medicine at the University of Pennsylvania. Biography Friedman was born on October 27, 1903, in Gary, Indiana, United States. Aged 16, he entered the University of Chicago and was awarded a bachelor's degree and doctorates, both in physiology and medicine. From 1928, he taught at the University of Pennsylvania in physiology. He moved to Washington in 1936 and joined the Georgetown University Hospital and held roles at the Georgetown University School of Medicine and the Washington Hospital Center. He gained employment at the Henry A. Wallace Beltsville Agricultural Research Center, where he continued with his research in reproductive physiology. He retired from medical work in 1959 and joined the Planned Parenthood, Children ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mice
A mouse ( : mice) is a small rodent. Characteristically, mice are known to have a pointed snout, small rounded ears, a body-length scaly tail, and a high breeding rate. The best known mouse species is the common house mouse (''Mus musculus''). Mice are also popular as pets. In some places, certain kinds of field mice are locally common. They are known to invade homes for food and shelter. Mice are typically distinguished from rats by their size. Generally, when a muroid rodent is discovered, its common name includes the term ''mouse'' if it is smaller, or ''rat'' if it is larger. The common terms ''rat'' and ''mouse'' are not taxonomically specific. Typical mice are classified in the genus ''Mus'', but the term ''mouse'' is not confined to members of ''Mus'' and can also apply to species from other genera such as the deer mouse, ''Peromyscus''. Domestic mice sold as pets often differ substantially in size from the common house mouse. This is attributable to breeding an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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