|
Robert Duggan (venture Capitalist)
Robert W. Duggan (born 1944) is an American billionaire entrepreneur, biotech and health care executive. He is the former CEO of biopharmaceutical company Pharmacyclics and was previously CEO of surgical systems maker Computer Motion from 1997 to 2003. Duggan is the majority shareholder and CEO of Pulse Biosciences and Summit Therapeutics. Early life Robert Duggan was born in Oakland, California, in 1944; the third of five children. His father was an Irish immigrant who became an industrial engineer in the U.S; his mother was a nurse. According to Robert Duggan in Investopedia, “We [our family] made about $800 a month…The last couple days of every month we scrambled around the house looking for lost quarters, dimes, and nickels [to pay the bills]." Duggan attended St. Francis High School in Mountain View, California, where he was both the captain and quarterback of the school football team. He is recorded as saying “I captained my football team, I'd get in a huddle, and I' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California, Santa Barbara
The University of California, Santa Barbara (UC Santa Barbara or UCSB) is a Public university, public Land-grant university, land-grant research university in Santa Barbara County, California, United States. Tracing its roots back to 1891 as an independent teachers college, UCSB joined the University of California system in 1944. It is the third-oldest undergraduate campus in the system, after University of California, Berkeley, UC Berkeley and University of California, Los Angeles, UCLA. UCSB's campus sits on the oceanfront site of a converted WWII-era United States Marine Corps, Marine Corps air station. UCSB is organized into three undergraduate colleges (UCSB College of Letters and Science, Letters and Science, UCSB College of Engineering, Engineering, College of Creative Studies, Creative Studies) and two graduate schools (Gevirtz Graduate School of Education, Education and Bren School of Environmental Science & Management, Environmental Science & Management), offering more ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Panera Bread
Panera Bread is an American multinational chain of bakery-café fast casual restaurants with over 2,000 locations, all of which are in the United States and Canada. Its headquarters are in Fenton, Missouri. The chain operates as Saint Louis Bread Company in the Greater St. Louis area, with over 100 locations. Panera offers a wide array of pastries and baked goods, such as bagels, brownies, cookies, croissants, muffins, and scones. These, along with Panera's artisan breads, are typically baked by an on-staff baker the day before. Aside from the bakery section, Panera has a regular menu for dine-in or takeout including flatbreads, pizzas, warm grain bowls, panini, pasta, salads, sandwiches, side choices, and soups, as well as coffee, espresso drinks, frozen drinks, fruit smoothies, hot chocolate, iced drinks, lattes, lemonade, and tea. Panera Bread, formerly owned by Au Bon Pain, is currently owned by JAB Holding Company, which is, in turn, owned by the Reimann family of G ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
USA Today
''USA Today'' (often stylized in all caps) is an American daily middle-market newspaper and news broadcasting company. Founded by Al Neuharth in 1980 and launched on September 14, 1982, the newspaper operates from Gannett's corporate headquarters in New York City. Its newspaper is printed at 37 sites across the United States and at five additional sites internationally. The paper's dynamic design influenced the style of local, regional, and national newspapers worldwide through its use of concise reports, colorized images, informational graphics, and inclusion of popular culture stories, among other distinct features. As of 2023, ''USA Today'' has the fifth largest print circulation in the United States, with 132,640 print subscribers. It has two million digital subscribers, the fourth-largest online circulation of any U.S. newspaper. ''USA Today'' is distributed in all 50 states, Washington, D.C., and Puerto Rico, and an international edition is distributed in Asia, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AbbVie
AbbVie Inc. is an American pharmaceutical company headquartered in North Chicago, Illinois. It is ranked sixth on the list of largest biomedical companies by revenue. In 2023, the company's seat in Forbes Global 2000 was 74, and rank 89 on the 2024 list. The company's primary product is Humira (adalimumab) ($14billion in 2023 revenues, 27percent of total), administered via injection. It is approved to treat autoimmune diseases including rheumatoid arthritis, Crohn's disease, plaque psoriasis, and ulcerative colitis. It developed Skyrizi ($7.8billion in 2023 revenues), an interleukin-23 (IL-23) inhibitor also used to treat autoimmune diseases. Its other major products include Botox ($5.7billion in 2023 revenues), Imbruvica to treat cancer ($3.6billion in 2023 revenues), Rinvoq to treat arthritis ($4billion in 2023 revenues), Venclexta to treat leukemia and lymphoma ($2.3billion in 2023 revenues), Vraylar to treat schizophrenia and bipolar disorder ($2.7billion in 2023 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chronic Lymphocytic Leukemia
Chronic lymphocytic leukemia (CLL) is a type of cancer that affects the blood and bone marrow. In CLL, the bone marrow makes too many lymphocytes, which are a type of white blood cell. In patients with CLL, B cell lymphocytes can begin to collect in their blood, spleen, lymph nodes, and bone marrow. These cells do not function well and crowd out healthy blood cells. CLL is divided into two main types: # Slow-growing CLL (indolent CLL) # Fast-growing CLL Many people do not have any symptoms when they are first diagnosed. Those with symptoms (about 5-10% of patients with CLL) may experience the following: * Fevers * Fatigue * Night sweats * Unexplained weight loss * Loss of appetite * Painless lymph node swelling * Splenomegaly, Enlargement of the spleen, and/or * A anemia, low red blood cell count (anemia). These symptoms may worsen over time. While the exact cause of CLL is unknown, having a family member with CLL increases one's risk of developing the disease. Environmental ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
B Cell
B cells, also known as B lymphocytes, are a type of the lymphocyte subtype. They function in the humoral immunity component of the adaptive immune system. B cells produce antibody molecules which may be either secreted or inserted into the plasma membrane where they serve as a part of B-cell receptors. When a naïve or memory B cell is activated by an antigen, it proliferates and differentiates into an antibody-secreting effector cell, known as a plasmablast or plasma cell. In addition, B cells Antigen presentation, present antigens (they are also classified as professional Antigen-presenting cell, antigen-presenting cells, APCs) and secrete cytokines. In mammals B cells Cellular differentiation, mature in the bone marrow, which is at the core of most bones. In birds, B cells mature in the bursa of Fabricius, a lymphoid organ where they were first discovered by Chang and Glick, which is why the ''B'' stands for ''bursa'' and not ''bone marrow'', as commonly believed. B cells, unl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ibrutinib
Ibrutinib, sold under the brand name Imbruvica among others, is a small molecule drug that inhibits B-cell proliferation and survival by irreversibly binding the protein Bruton's tyrosine kinase (BTK). Blocking BTK inhibits the B-cell receptor pathway, which is often aberrantly active in B cell cancers. Ibrutinib is therefore used to treat such cancers, including mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenström's macroglobulinemia. Ibrutinib also binds to C-terminal Src Kinases. These are off-target receptors for the BTK inhibitor. Ibrutinib binds to these receptors and inhibits the kinase from promoting cell differentiation and growth. This leads to many different side effects like left atrial enlargement and atrial fibrillation during the treatment of Chronic Lymphocytic Leukemia. It is on the World Health Organization's List of Essential Medicines. Medical uses Ibrutinib is indicated for the treatment of mantle cell lymphoma (MCL), chronic lymphocytic l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lindbergh Operation
The Lindbergh operation was a complete tele-surgical operation carried out by a team of French surgeons located in New York on a patient in Strasbourg, France (over a distance of several thousand miles) using telecommunications solutions based on high-speed services and sophisticated Zeus surgical robot. The operation was performed successfully on September 7, 2001 by Professor Jacques Marescaux and his team from the IRCAD (Institute for Research into Cancer of the Digestive System). This was the first time in medical history that a technical solution proved capable of reducing the time delay inherent to long distance transmissions sufficiently to make this type of procedure possible. The name was derived from the American aviator Charles Lindbergh, because he was the first person to fly solo across the Atlantic Ocean. Details of the procedure The operation involved minimally invasive surgery: The 45-minute procedure consisted of a cholecystectomy on a 68-year-old female patien ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Robot-assisted Surgery
Robot-assisted surgery or robotic surgery are any types of surgical procedures that are performed using robotic systems. Robotically assisted surgery was developed to try to overcome the limitations of pre-existing minimally-invasive surgical procedures and to enhance the capabilities of surgeons performing open surgery. In the case of robotically assisted minimally-invasive surgery, instead of the surgeon directly moving the instruments, the surgeon uses one of two methods to perform dissection, hemostasis and resection, using a direct telemanipulator, or through computer control. * A telemanipulator (e.g. the da Vinci Surgical System) is a system of remotely controlled manipulators that allows the surgeon to operate real-time under stereoscopic vision from a control console separate from the operating table. The robot is docked next to the patient, and robotic arms carry out endoscopy-like maneuvers via end-effectors inserted through specially designed trocars. A surgica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intuitive Surgical
Intuitive Surgical, Inc. is an American biotechnology company that develops, manufactures, and markets robotic products designed to improve clinical outcomes of patients through minimally invasive surgery, most notably with the ''da Vinci'' Surgical System. The company is part of the Nasdaq-100, S&P 100 and S&P 500. , Intuitive Surgical had an installed base of 6,730 da Vinci Surgical Systems, including 4,139 in the U.S., 1,199 in Europe, 1,050 in Asia, and 342 in the rest of the world. Intuitive Surgical made its debut on the ''Fortune'' 500 list in 2024, ranking #497. History The research that eventually led to the development of the ''da Vinci'' Surgical System was performed in the late 1980s by Ajit Shah and Gary Guthart at research institute SRI International. In 1990, SRI received funding from the National Institutes of Health. SRI developed a prototype robotic surgical system that caught the interest of the Defense Advanced Research Projects Agency (DARPA), which was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
JCDecaux Group
JCDecaux Group (JCDecaux SA, ) is a multinational corporation focused on outdoor advertising. As of 2016, it is the largest company in its sector worldwide with adverts on 140.000 bus stops and 145 airports. The company is headquartered in Neuilly-sur-Seine, near Paris, France. The company was founded in 1964 in Lyon by Jean-Claude Decaux who led the company until 2000. The company has been criticized for promoting Russian propaganda on the Oslo Metro in support of the Russian invasion of Ukraine. History Jean-Claude Decaux (1937-2016) first created a company in 1955 that specialised in outdoor advertising alongside motorways. However, as these billboards were heavily taxed by law, Jean-Claude Decaux turned towards a business model in 1964 that was based on city billboards and invented the concept of advertising street furniture – well-maintained bus shelters fully funded by advertisers. In 1999, the group acquired Havas Media Communication and Avenir. This acquisitio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Capital Research & Management
Capital Group is an American investment management company. It ranks among the world's oldest and largest investment management organizations, with over $2.6 trillion in assets under management. Founded in Los Angeles, California in 1931, it is privately held and has offices around the globe in the Americas, Asia, Australia and Europe. Capital offers a range of products focused on active management, including more than 40 mutual funds through its subsidiary, American Funds Distributors, as well as separately managed accounts (or collective investment trusts), private equity, investment services for high net worth investors in the U.S., and a range of other offerings for institutional clients and individual investors globally. History In 1931, Jonathan Bell Lovelace founded the investment firm, ''Lovelace, Dennis & Renfrew'', which would eventually become Capital Group. Lovelace had previously been a partner in the stock brokerage firm ''E.E. MacCrone'', where he explored the c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
