Porton Down
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Porton Down
Porton Down is a science park in Wiltshire, England, just northeast of the village of Porton, near Salisbury. It is home to two British government facilities: a site of the Ministry of Defence's Defence Science and Technology Laboratory (Dstl) – known for over 100 years as one of the UK's most secretive and controversial military research facilities, occupying – and a site of the UK Health Security Agency. It is also home to other private and commercial science organisations, and is expanding to attract other companies. Location Porton Down is located just northeast of the village of Porton near Salisbury, in Wiltshire, England. To the northwest lies the MoD Boscombe Down airfield operated by QinetiQ. On some maps, the land surrounding the complex is identified as a "Danger Area". History of government use Porton Down opened in 1916 as the War Department Experimental Station, shortly thereafter renamed the Royal Engineers Experimental Station, for testing chemical w ...
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Porton (village)
Porton is a village in the River Bourne, Wiltshire, Bourne valley, Wiltshire, England, about northeast of Salisbury. It is the largest settlement in Idmiston Civil parishes in England, civil parish. The village gives its name to the nearby Porton Down military science park, which is home to the Defence Science and Technology Laboratory and related businesses. Religious sites The Baptists, Baptist faith flourished in this part of Wiltshire in the 17th century, then declined in the 18th. A chapel was built to the south of Porton village in 1865 and enlarged in 1922, 1972 and 2006; as of 2015 it is still open. The Church of England, Anglican Church of St Nicholas was built in 1877 to designs by John Loughborough Pearson, J.L. Pearson, replacing a building from the 16th century or earlier. Built in flint with brick dressings under a tiled roof, the church has a nave with a south porch and bellcote, and a chancel with a vestry. The octagonal font is from the 14th or 15th century, a ...
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Idmiston
Idmiston is a village and civil parish in Wiltshire, England. The village is about southeast of Amesbury and northeast of Salisbury. The parish includes the villages of Porton and Gomeldon; all three villages are on the River Bourne and are linked by the A338 road. Porton Down military science park is in the parish, separated from Idmiston by a railway line. It is home to the Defence Science and Technology Laboratory and related businesses. History The Port Way, a Roman road towards Sorviodunum (Old Sarum), followed the Bourne valley and passed close to the present settlements. The Domesday survey in 1086 recorded 15 households at ''Eunestetone'' (Idmiston), on land held by Glastonbury Abbey; and eight at ''Poertone'' or ''Portone'', on land held by Edward of Salisbury and Wulfric the hunter. Idmiston Manor is a house from c. 1600 with 17th-century interior features and an arched gateway from the same period; both house and gateway are Grade II* listed. The Old Rectory, ...
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Paul Fildes
Sir Paul Gordon Fildes (10 February 1882 – 5 February 1971) was a British pathologist and microbiologist who worked on the development of chemical-biological weaponry at Porton Down during the Second World War.


Biography


Early life

Fildes was born in Kensington, London, the son of the artist Sir Luke Fildes and great grandson of reformist Mary Fildes, Paul attended Winchester School and then studied surgery at Trinity College, Cambridge, where he obtained an Bachelor of Medicine and Surgery, MB BCh degree.


Career

Fildes served as a Lieutenant commander (Royal Navy), lieutenant-commander in the Royal Naval Volunteer Reserve, stationed at the Royal Naval Hospital Haslar (1915–19) during the First World War. In 1919 he was made an Officer of the Order of the British ...
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Sarin
Sarin (NATO designation GB G-series, "B"">Nerve_agent#G-series.html" ;"title="hort for Nerve agent#G-series">G-series, "B" is an extremely toxic synthetic organophosphorus compound.Sarin (GB)
Emergency Response Safety and Health Database. National Institute for Occupational Safety and Health. Accessed April 20, 2009.
A colourless, odourless , it is used as a due to its extreme potency as a . Exposure is lethal even at very low concen ...
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Nerve Agent
Nerve agents, sometimes also called nerve gases, are a class of organic chemicals that disrupt the mechanisms by which nerves transfer messages to organs. The disruption is caused by the blocking of acetylcholinesterase (AChE), an enzyme that catalyzes the breakdown of acetylcholine, a neurotransmitter. Nerve agents are acetylcholinesterase inhibitors used as poison. Poisoning by a nerve agent leads to constriction of pupils, profuse salivation, convulsions, and involuntary urination and defecation, with the first symptoms appearing in seconds after exposure. Death by asphyxiation or cardiac arrest may follow in minutes due to the loss of the body's control over respiratory and other muscles. Some nerve agents are readily vaporized or aerosolized, and the primary portal of entry into the body is the respiratory system. Nerve agents can also be absorbed through the skin, requiring that those likely to be subjected to such agents wear a full body suit in addition to a respirato ...
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Allies Of World War II
The Allies, formally referred to as the United Nations from 1942, were an international military coalition formed during the Second World War (1939–1945) to oppose the Axis powers, led by Nazi Germany, Imperial Japan, and Fascist Italy. Its principal members by 1941 were the United Kingdom, United States, Soviet Union, and China. Membership in the Allies varied during the course of the war. When the conflict broke out on 1 September 1939, the Allied coalition consisted of the United Kingdom, France, and Poland, as well as their respective dependencies, such as British India. They were soon joined by the independent dominions of the British Commonwealth: Canada, Australia, New Zealand and South Africa. Consequently, the initial alliance resembled that of the First World War. As Axis forces began invading northern Europe and the Balkans, the Allies added the Netherlands, Belgium, Norway, Greece, and Yugoslavia. The Soviet Union, which initially had a nonaggression pa ...
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Nitrogen Mustard
Nitrogen mustards are cytotoxic organic compounds with the chloroethylamine (Cl(CH2)2NR2) functional group. Although originally produced as chemical warfare agents, they were the first chemotherapeutic agents for treatment of cancer. Nitrogen mustards are nonspecific DNA alkylating agents. Chemical warfare During World War II nitrogen mustards were studied at the Yale School of Medicine by Alfred Gilman and Louis Goodman, and classified human clinical trials of nitrogen mustards for the treatment of lymphoma started in December 1942. Also during World War II, an incident during the air raid on Bari, Italy, led to the release of mustard gas that affected several hundred soldiers and civilians. Medical examination of the survivors showed a decreased number of lymphocytes. After World War II was over, the Bari incident and the Yale group's studies eventually converged prompting a search for other similar compounds. Due to its use in previous studies, the nitrogen mustard known ...
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Second World War
World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposing military alliances: the Allies and the Axis powers. World War II was a total war that directly involved more than 100 million personnel from more than 30 countries. The major participants in the war threw their entire economic, industrial, and scientific capabilities behind the war effort, blurring the distinction between civilian and military resources. Aircraft played a major role in the conflict, enabling the strategic bombing of population centres and deploying the only two nuclear weapons ever used in war. World War II was by far the deadliest conflict in human history; it resulted in 70 to 85 million fatalities, mostly among civilians. Tens of millions died due to genocides (including the Holocaust), starvation, ma ...
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British Indian Army
The British Indian Army, commonly referred to as the Indian Army, was the main military of the British Raj before its dissolution in 1947. It was responsible for the defence of the British Indian Empire, including the princely states, which could also have their own armies. As quoted in the Imperial Gazetteer of India, "The British Government has undertaken to protect the dominions of the Native princes from invasion and even from rebellion within: its army is organized for the defence not merely of British India, but of all possessions under the suzerainty of the King-Emperor." The Indian Army was an important part of the British Empire's forces, both in India and abroad, particularly during the First World War and the Second World War. The term ''Indian Army'' appears to have been first used informally, as a collective description of the Presidency armies, which collectively comprised the Bengal Army, the Madras Army and the Bombay Army, of the Presidencies of British India ...
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Rawalpindi Experiments
The Rawalpindi experiments were experiments involving use of mustard gas carried out by British scientists from Porton Down on hundreds of soldiers from the British Indian Army. These experiments were carried out before and during the Second World War in a military installation at Rawalpindi, in modern-day Pakistan. These experiments began in the early 1930s and lasted more than 10 years. Since the publication of the story in ''The Guardian'' on 1 September 2007, the experiments have been referred to as the Rawalpindi experiments or Rawalpindi mustard gas experiments in the media and elsewhere. Oversight by Porton Down The experiments in Rawalpindi were part of a much larger project intended to test the effects of chemical weapons on humans. More than 20,000 British servicemen were subjected to chemical warfare trials between 1916 and 1989 at the Defence Ministry's Porton Down research centre in southwest England. Aim of the experiments The experiments were done to determine ...
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Chemical Warfare
Chemical warfare (CW) involves using the toxic properties of chemical substances as weapons. This type of warfare is distinct from nuclear warfare, biological warfare and radiological warfare, which together make up CBRN, the military acronym for chemical, biological, radiological, and nuclear (warfare or weapons), all of which are considered "weapons of mass destruction" (WMDs), a term that contrasts with conventional weapons. The use of chemical weapons is prohibited under customary international humanitarian law. Definition Chemical warfare is different from the use of conventional weapons or nuclear weapons because the destructive effects of chemical weapons are not primarily due to any explosive force. The offensive use of living organisms (such as anthrax) is considered biological warfare rather than chemical warfare; however, the use of nonliving toxic products produced by living organisms (e.g. toxins such as botulinum toxin, ricin, and saxitoxin) ''is'' consider ...
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