Papiine Betaherpesvirus 3
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Papiine Betaherpesvirus 3
''Papiine betaherpesvirus 3'' (PaHV-3) is a species of virus in the genus ''Cytomegalovirus'', subfamily ''Betaherpesvirinae'', family ''Herpesviridae'', and order ''Herpesvirales The ''Herpesvirales'' is an order of dsDNA viruses (Baltimore group I) with animal hosts, characterised by a common morphology consisting of an icosahedral capsid enclosed in a glycoprotein-containing lipid envelope. Common infections in humans ...''. References Betaherpesvirinae {{Virus-stub ...
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Cytomegalovirus
''Cytomegalovirus'' (''CMV'') (from ''cyto-'' 'cell' via Greek - 'container' + 'big, megalo-' + -''virus'' via Latin 'poison') is a genus of viruses in the order '' Herpesvirales'', in the family '' Herpesviridae'', in the subfamily '' Betaherpesvirinae''. Humans and other primates serve as natural hosts. The 11 species in this genus include '' human betaherpesvirus 5'' (HCMV, human cytomegalovirus, HHV-5), which is the species that infects humans. Diseases associated with HHV-5 include mononucleosis and pneumonia. In the medical literature, most mentions of CMV without further specification refer implicitly to human CMV. Human CMV is the most studied of all cytomegaloviruses. MX2/MXB was identified as a restriction factor for herpesviruses, which acts at a very early stage of the replication cycle and MX2/MXB restriction of herpesvirus requires GTPase activity. Taxonomy Within the '' Herpesviridae'', CMV belongs to the '' Betaherpesvirinae'' subfamily, which also inclu ...
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Betaherpesvirinae
''Betaherpesvirinae'' is a subfamily of viruses in the order ''Herpesvirales'' and in the family ''Herpesviridae''. Mammals serve as natural hosts. There are 26 species in this subfamily, divided among 5 genera. Diseases associated with this subfamily include: human cytomegalovirus (HHV-5): congenital CMV infection; HHV-6: ' sixth disease' (also known as ''roseola infantum'' or ''exanthem subitum''); HHV-7: symptoms analogous to the 'sixth disease'. Genera ''Betaherpesvirinae'' consists of the following five genera: * ''Cytomegalovirus'' * '' Muromegalovirus'' * ''Proboscivirus'' * ''Quwivirus'' * ''Roseolovirus'' Structure Viruses in ''Betaherpesvirinae'' are enveloped, with icosahedral, spherical to pleomorphic, and Round geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and non-segmented, around 140-240kb in length. Life cycle Viral replication is nuclear, and is lysogenic. Entry into the host cell is achieved by attachment o ...
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Herpesviridae
''Herpesviridae'' is a large family of DNA viruses that cause infections and certain diseases in animals, including humans. The members of this family are also known as herpesviruses. The family name is derived from the Greek word ''ἕρπειν'' ( 'to creep'), referring to spreading cutaneous lesions, usually involving blisters, seen in flares of herpes simplex 1, herpes simplex 2 and herpes zoster (shingles). In 1971, the International Committee on the Taxonomy of Viruses (ICTV) established ''Herpesvirus'' as a genus with 23 viruses among four groups. As of 2020, 115 species are recognized, all but one of which are in one of the three subfamilies. Herpesviruses can cause both latent and lytic infections. Nine herpesvirus types are known to primarily infect humans, at least five of which – herpes simplex viruses 1 and 2 (HSV-1 and HSV-2, also known as HHV-1 and HHV-2; both of which can cause orolabial herpes and genital herpes), varicella zoster virus (or HHV-3; the cau ...
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Herpesvirales
The ''Herpesvirales'' is an order of dsDNA viruses (Baltimore group I) with animal hosts, characterised by a common morphology consisting of an icosahedral capsid enclosed in a glycoprotein-containing lipid envelope. Common infections in humans caused by members of this order include cold sores, genital herpes, chickenpox, shingles, and glandular fever. ''Herpesvirales'' is the sole order in the class ''Herviviricetes'', which is the sole class in the phylum ''Peploviricota''. Virology Morphology All members of the order have a virion structure that consists of a DNA core surrounded by an icosahedral capsid composed of 12 pentavalent and 150 hexavalent capsomeres (T = 16). The capsid has a diameter of ~110 nanometers (nm) and is embedded in a proteinaceous matrix called the tegument, which in its turn is enclosed by a glycoprotein-containing lipid envelope with a diameter of about 200 nm. The DNA genome is linear and double stranded, with sizes in the range 125–2 ...
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