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Oropouche Virus
Oropouche virus (OROV) is one of the most common orthobunyaviruses. When OROV infects humans, it causes a rapid fever illness called Oropouche fever. OROV was originally reported in Trinidad and Tobago in 1955 from the blood sample of a fever patient and from a pool of '' Coquillettidia venezuelensis'' mosquitoes. In 1960, OROV was isolated from a sloth ('' Bradypus tridactylus'') and a pool of '' Ochlerotatus serratus'' mosquitoes in Brazil. The virus is considered a public health threat in tropical and subtropical areas of Central and South America, with over half a million infected people as of 2005. OROV is considered to be an arbovirus due to the method of transmission by the mosquitoes '' Aedes serratus'' and '' Culex quinquefasciatus'' among sloths, marsupials, primates, and birds. Epidemic sites The virus causes Oropouche fever, an urban arboviral disease that has since resulted in >30 epidemics during 1960–2009. Between 1961 and 1980, OROV was reported in the norther ...
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Orthobunyavirus
''Orthobunyavirus'' is a genus of the ''Peribunyaviridae'' family in the order '' Elliovirales''. The genus contains 138 species. The name ''Orthobunyavirus'' derives from Bunyamwera, Uganda, where Bunyamwera virus was first discovered, along with the prefix () meaning 'straight.' Epidemiology The genus is most diverse in Africa and Oceania, but occurs almost worldwide. Most orthobunyavirus species are transmitted by gnats and cause diseases of cattle. The California encephalitis virus, the La Crosse virus and the Jamestown Canyon virus are North American species that cause encephalitis in humans. Virology *The virus is spherical, diameter 80 nm to 120 nm, and comprises three negative-sense single stranded RNA molecules encapsulated in a ribonucleocapsid. *The three RNAs are described as S, M and L (for Small, Medium and Large) and are circa 1kb (kilobases), 4.5kb and 6.9kb in length *The S RNA encodes the Nucleocapsid protein (N protein) and a non structural pro ...
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Genotype
The genotype of an organism is its complete set of genetic material. Genotype can also be used to refer to the alleles or variants an individual carries in a particular gene or genetic location. The number of alleles an individual can have in a specific gene depends on the number of copies of each chromosome found in that species, also referred to as ploidy. In diploid species like humans, two full sets of chromosomes are present, meaning each individual has two alleles for any given gene. If both alleles are the same, the genotype is referred to as Zygosity, homozygous. If the alleles are different, the genotype is referred to as heterozygous. Genotype contributes to phenotype, the observable traits and characteristics in an individual or organism. The degree to which genotype affects phenotype depends on the trait. For example, the petal color in a pea plant is exclusively determined by genotype. The petals can be purple or white depending on the alleles present in the pea plan ...
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Apoptosis
Apoptosis (from ) is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast. Biochemistry, Biochemical events lead to characteristic cell changes (Morphology (biology), morphology) and death. These changes include Bleb (cell biology), blebbing, Plasmolysis, cell shrinkage, Karyorrhexis, nuclear fragmentation, Pyknosis, chromatin condensation, Apoptotic DNA fragmentation, DNA fragmentation, and mRNA decay. The average adult human loses 50 to 70 1,000,000,000, billion cells each day due to apoptosis. For the average human child between 8 and 14 years old, each day the approximate loss is 20 to 30 billion cells. In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's life cycle. For example, the separation of fingers and toes in a developing human embryo ...
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HeLa
HeLa () is an immortalized cell line used in scientific research. It is the oldest human cell line and one of the most commonly used. HeLa cells are durable and prolific, allowing for extensive applications in scientific study. The line is derived from cervical cancer cells taken on February 8, 1951, from Henrietta Lacks, a 31-year-old African American mother of five, after whom the line is named. Lacks died of cancer on October 4, 1951. The cells from Lacks's cancerous cervical tumor were taken without her knowledge, which was common practice in the United States at the time. Cell biologist George Otto Gey found that they could be kept alive, and developed a cell line. Previously, cells cultured from other human cells would survive for only a few days, but cells from Lacks's tumor behaved differently. History Origin In 1951, Henrietta Lacks was admitted to the Johns Hopkins Hospital with symptoms of irregular vaginal bleeding; she was subsequently treated for cerv ...
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Manaus
Manaus () is the List of capitals of subdivisions of Brazil, capital and largest city of the States of Brazil, Brazilian state of Amazonas (Brazilian state), Amazonas. It is the List of largest cities in Brazil, seventh-largest city in Brazil, with an estimated 2022 population of 2,063,689 distributed over a land area of about . Located at the east centre of the state, the city is the centre of the Greater Manaus, Manaus metropolitan area and the largest metropolitan area in the North Region, Brazil, North Region of Brazil by urban landmass. It is situated near Meeting of Waters, the confluence of the Rio Negro (Amazon), Negro and Amazon River, Amazon rivers. It is one of the two cities in the Amazon rainforest with a population of over 1 million people, alongside Belém. The city was founded in 1669 as the Fort of São José do Rio Negro. It was elevated to a town in 1832 with the name of "Manaus", an altered spelling of the indigenous Manaós peoples, and legally transformed in ...
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Minas Gerais
Minas Gerais () is one of the 27 federative units of Brazil, being the fourth largest state by area and the second largest in number of inhabitants with a population of 20,539,989 according to the 2022 Brazilian census, 2022 census. Located in the Southeast Region, Brazil, Southeast Region of the country, it is bordered to south and southwest by São Paulo (state), São Paulo; Mato Grosso do Sul to the west; Goiás and the Federal District (Brazil), Federal District to the northwest; Bahia to the north and northeast; Espírito Santo to the east; and Rio de Janeiro (state), Rio de Janeiro to the southeast. The state's capital and largest city, Belo Horizonte, is a major urban and finance center in Brazil, being the List of largest cities in Brazil#Top 115 most populous cities and state capitals, sixth most populous municipality in the country while its Greater Belo Horizonte, metropolitan area ranks as the List of metropolitan areas in Brazil, third largest in Brazil with just ov ...
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Rondônia
Rondônia () is one of the 26 states of Brazil, located in the northern subdivision of the country (central-western part). It is bordered by Acre (state), Acre in the west, Amazonas, Brazil, Amazonas in the north, Mato Grosso in the east, and Bolivia in the south. Rondônia has a population of 1,815,000 as of 2021. It is the fifth least populated state. Its capital and largest city is Porto Velho, bathed by the Madeira River. The state was named after Cândido Rondon, who explored the north of the country during the 1910s. The state, which is home to c. 0.7% of the Brazilian population, is responsible for c. 0.3% of the Brazilian GDP. The state has 52 municipalities and occupies an area of 237,590.547 Square kilometre, km2, equivalent to the territory of Romania and almost five times larger than Croatia. In addition to this, there are other important cities such as Ariquemes, Cacoal, Guajará-Mirim, Ji-Paraná, Rolim de Moura and Vilhena. Geography Rondonia used to be home to ...
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Amapá
Amapá (; ) is one of the 26 federative units of Brazil, states of Brazil. It is in the North Region, Brazil, North Region of Brazil. It is Federative units of Brazil#List, the second-least populous state and the eighteenth-largest state by area. Located in the far northern part of the country, Amapá is bordered clockwise by French Guiana to the north for 730 km, the Atlantic Ocean to the east for 578 km, Pará to the south and west, and Suriname to the northwest for 63 km. The capital and largest city is Macapá. The state has 0.4% of the Brazilian population and is responsible for only 0.22% of the Brazilian gross domestic product, GDP. In the colonial period the region was called Portuguese Guiana and was part of Portuguese Empire, Portugal's State of Brazil. Later, the region was distinguished from the other The Guianas, Guianas. Amapá was once part of Pará, but became a separate territory in 1943, and the decision to make it a state was made in 1988. The first state legis ...
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Tocantins
Tocantins () is one of the 26 states of Brazil. It is the newest state, formed in 1988 and encompassing what had formerly been the northern two-fifths of the state of Goiás. Tocantins covers and had an estimated population of 1,496,880 in 2014. Construction of its capital, Palmas, began in 1989; most of the other cities in the state date to the Portuguese colonial period. With the exception of Araguaína, there are few other cities with a significant population in the state. The government has invested in a new capital, a major hydropower dam, railroads and related infrastructure to develop this primarily agricultural area. The state has 0.75% of the Brazilian population and is responsible for 0.5% of the Brazilian GDP. Tocantins has attracted hundreds of thousands of new residents, primarily to Palmas. It is building on its hydropower resources. The Araguaia and Tocantins rivers drain the largest watershed that lies entirely inside Brazilian territory. The Rio Tocantins ...
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Maranhão
Maranhão () is a States of Brazil, state in Brazil. Located in the country's Northeast Region, Brazil, Northeast Region, it has a population of about 7 million and an area of and it is divided into 217 municipalities. Clockwise from north, it borders on the Atlantic Ocean for 2,243 km and the states of Piauí, Tocantins and Pará. The people of Maranhão have a distinctive accent within the common Northeastern Brazilian dialect. Maranhão is described in literary works such as ''Canção do exílio, Exile Song'' by Gonçalves Dias and ''Casa de Pensão'' by Aluísio Azevedo. The dunes of Lençóis Maranhenses National Park, Lençóis are an important area of environmental preservation. Also of interest is the state capital of São Luís, Maranhão, São Luís, which is a UNESCO World Heritage Site. Another important conservation area is the Parnaíba River delta, between the states of Maranhão and Piauí, with its lagoons, desert dunes and deserted beaches or islands, suc ...
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Pará
Pará () is a Federative units of Brazil, state of Brazil, located in northern Brazil and traversed by the lower Amazon River. It borders the Brazilian states of Amapá, Maranhão, Tocantins (state), Tocantins, Mato Grosso, Amazonas (Brazilian state), Amazonas and Roraima. To the northwest are the borders of Guyana and Suriname, to the northeast of Pará is the Atlantic Ocean. The capital and largest city is Belém, which is located at the Marajó bay, near the estuary of the Amazon river. The state, which is home to 4.1% of the Brazilian population, is responsible for just 2.2% of the Brazilian GDP. Pará is the most populous state of the North Region, Brazil, North Region, with a population of over 8.6 million, being the ninth-most populous state in Brazil. It is the second-largest state of Brazil in area, at , second only to Amazonas (Brazilian state), Amazonas upriver. Its most famous icons are the Amazon River and the Amazon rainforest. Pará produces Natural rubber, rubber ( ...
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Progeny (genetic Descendant)
In biology, offspring are the young creation of living organisms, produced either by sexual or asexual reproduction. Collective offspring may be known as a brood or progeny. This can refer to a set of simultaneous offspring, such as the chicks hatched from one clutch of eggs, or to all offspring produced over time, as with the honeybee. Offspring can occur after mating, artificial insemination, or as a result of cloning. Human offspring ( descendants) are referred to as children; male children are sons and female children are daughters (see Kinship). Overview Offspring contains many parts and properties that are precise and accurate in what they consist of, and what they define. As the offspring of a new species, also known as a child or f1 generation, consist of genes of the father and the mother, which is also known as the parent generation. Each of these offspring contains numerous genes which have coding for specific tasks and properties. Males and females both contrib ...
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