Microsporum Canis
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Microsporum Canis
''Microsporum canis'' is a pathogenic, asexual fungus in the phylum Ascomycota that infects the upper, dead layers of skin on domesticated cats, and occasionally dogs and humans. The species has a worldwide distribution. Taxonomy and evolution ''Microsporum canis'' reproduces by means of two conidial forms, large, spindle-shaped, multicelled macroconidia and small, single-celled microconidia. First records of ''M. canis'' date to 1902. Evolutionary studies have established that ''M. canis'', like the very closely related sibling species ''M. distortum'' and ''M. equinum'', is a genetic clone derived from the sexually reproducing species, ''Arthroderma otae''. Members of Ascomycota often possess conspicuous asexual and sexual forms that can coexist in time and space. ''Microsporum canis'' exemplifies a common situation in ascomycetous fungi in which, over time, one mating type strain has undergone habitat divergence from the other and established a self-sustaining reproductive p ...
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Macroconidia
A conidium ( ; ), sometimes termed an asexual chlamydospore or chlamydoconidium (), is an Asexual reproduction, asexual, non-motility, motile spore of a fungus. The word ''conidium'' comes from the Ancient Greek word for dust, ('). They are also called mitospores due to the way they are generated through the cellular process of mitosis. The two new haploid cells are genetically identical to the haploid parent, and can develop into new organisms if conditions are favorable, and serve in biological dispersal. Asexual reproduction in ascomycetes (the phylum Ascomycota) is by the formation of conidia, which are borne on specialized stalks called conidiophores. The Morphology (biology), morphology of these specialized conidiophores is often distinctive between species and, before the development of molecular techniques at the end of the 20th century, was widely used for identification of (''e.g.'' ''Metarhizium#Species, Metarhizium'') species. The terms microconidia and macroconidi ...
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Tinea Capitis
Tinea capitis (also known as "herpes tonsurans", "ringworm of the hair", "ringworm of the scalp", "scalp ringworm", and "tinea tonsurans") is a cutaneous fungal infection (dermatophytosis) of the scalp. The disease is primarily caused by dermatophytes in the genera ''Trichophyton'' and '' Microsporum'' that invade the hair shaft. The clinical presentation is typically single or multiple patches of hair loss, sometimes with a 'black dot' pattern (often with broken-off hairs), that may be accompanied by inflammation, scaling, pustules, and itching. Uncommon in adults, tinea capitis is predominantly seen in pre-pubertal children, more often boys than girls. At least eight species of dermatophytes are associated with tinea capitis. Cases of ''Trichophyton'' infection predominate from Central America to the United States and in parts of Western Europe. Infections from ''Microsporum'' species are mainly in South America, Southern and Central Europe, Africa and the Middle East. The dise ...
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Arthrodermataceae
The Arthrodermataceae are a family of fungi containing nine dermatophyte genera — '' Epidermophyton'', '' Microsporum'', ''Nannizzia'', ''Trichophyton ''Trichophyton'' is a genus of fungi, which includes the parasitic varieties that cause tinea, including athlete's foot, ringworm, jock itch, and similar infections of the nail, beard, skin and scalp. Trichophyton fungi are molds characterize ...'', ''Paraphyton'', ''Lophophyton'', ''Guarromyces'', ''Ctenomyces'' and ''Arthroderma''.de Hoog GS, Dukik K, Monod M, et al. Toward a novel multilocus phylogenetic taxonomy for the dermatophytes. Mycopathologia. 2017; 182(1-2): 5-31. References External links''Trichophyton'' spp.at Doctor FungusMycology Unit at the Adelaide Women's and Children's Hospital * Parasitic fungi Onygenales Ascomycota families {{parasite-stub ...
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Terbinafine
Terbinafine, sold under the brand name Lamisil among others, is an antifungal medication used to treat pityriasis versicolor, fungal nail infections, and ringworm including jock itch and athlete's foot. It is either taken by mouth or applied to the skin as a cream or ointment. The cream and ointment are not effective for nail infections. Common side effects when taken by mouth include nausea, diarrhea, headache, cough, rash, and elevated liver enzymes. Severe side effects include liver problems and allergic reactions. Liver injury is, however, unusual. Use during pregnancy is not typically recommended. The cream and ointment may result in itchiness but are generally well tolerated. Terbinafine is in the allylamines family of medications. It works by decreasing the ability of fungi to synthesize sterols. It appears to result in fungal cell death. Terbinafine was discovered in 1991. It is on the World Health Organization's List of Essential Medicines. In 2020, it was the 279t ...
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Itraconazole
Itraconazole, sometimes abbreviated ITZ, is an antifungal medication used to treat a number of fungal infections. This includes aspergillosis, blastomycosis, coccidioidomycosis, histoplasmosis, and paracoccidioidomycosis. It may be given by mouth or intravenously. Common side effects include nausea, diarrhea, abdominal pain, rash, and headache. Severe side effects may include liver problems, heart failure, Stevens–Johnson syndrome and allergic reactions including anaphylaxis. It is unclear if use during pregnancy or breastfeeding is safe. It is in the triazole family of medications. It stops fungal growth by affecting the cell membrane or affecting their metabolism. Itraconazole was patented in 1978 and approved for medical use in the United States in 1992. It is on the World Health Organization's List of Essential Medicines. Recent research works suggest itraconazole (ITZ) could also be used in the treatment of cancer by inhibiting the hedgehog pathway in a similar wa ...
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Griseofulvin
Griseofulvin is an antifungal medication used to treat a number of types of dermatophytoses (ringworm). This includes fungal infections of the nails and scalp, as well as the skin when antifungal creams have not worked. It is taken by mouth. Common side effects include allergic reactions, nausea, diarrhea, headache, trouble sleeping, and feeling tired. It is not recommended in people with liver failure or porphyria. Use during or in the months before pregnancy may result in harm to the baby. Griseofulvin works by interfering with fungal mitosis. Griseofulvin was discovered in 1939 from the soil fungus '' Penicillium griseofulvum''. It is on the World Health Organization's List of Essential Medicines. Medical uses Griseofulvin is used orally only for dermatophytosis. It is ineffective topically. It is reserved for cases in which topical treatment with creams is ineffective. Terbinafine given for 2 to 4 weeks is at least as effective as griseofulvin given for 6 to 8 weeks fo ...
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Alopecia
Hair loss, also known as alopecia or baldness, refers to a loss of hair from part of the head or body. Typically at least the head is involved. The severity of hair loss can vary from a small area to the entire body. Inflammation or scarring is not usually present. Hair loss in some people causes psychological distress. Common types include male- or female-pattern hair loss, alopecia areata, and a thinning of hair known as telogen effluvium. The cause of male-pattern hair loss is a combination of genetics and male hormones; the cause of female pattern hair loss is unclear; the cause of alopecia areata is autoimmune; and the cause of telogen effluvium is typically a physically or psychologically stressful event. Telogen effluvium is very common following pregnancy. Less common causes of hair loss without inflammation or scarring include the pulling out of hair, certain medications including chemotherapy, HIV/AIDS, hypothyroidism, and malnutrition including i ...
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Subcutaneous Tissue
The subcutaneous tissue (), also called the hypodermis, hypoderm (), subcutis, superficial fascia, is the lowermost layer of the integumentary system in vertebrates. The types of cells found in the layer are fibroblasts, adipose cells, and macrophages. The subcutaneous tissue is derived from the mesoderm, but unlike the dermis, it is not derived from the mesoderm's dermatome region. It consists primarily of loose connective tissue, and contains larger blood vessels and nerves than those found in the dermis. It is a major site of fat storage in the body. In arthropods, a hypodermis can refer to an epidermal layer of cells that secretes the chitinous cuticle. The term also refers to a layer of cells lying immediately below the epidermis of plants. Structure * Fibrous bands anchoring the skin to the deep fascia * Collagen and elastin fibers attaching it to the dermis * Fat is absent from the eyelids, clitoris, penis, much of pinna, and scrotum * Blood vessels on rout ...
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Leukemoid Reaction
The term leukemoid reaction describes an increased white blood cell count (> 50,000 cells/μL), which is a physiological response to stress or infection (as opposed to a primary blood malignancy, such as leukemia). It often describes the presence of immature cells such as myeloblasts or red blood cells with nuclei in the peripheral blood. It may be lymphoid or myeloid. Causes As noted above, a leukemoid reaction is typically a response to an underlying medical issue. Causes of leukemoid reactions include: * Severe hemorrhage (retroperitoneal hemorrhage) * Drugs ** Use of sulfa drugs ** Use of dapsone ** Use of glucocorticoids ** Use of G-CSF or related growth factors ** All-trans retinoic acid (ATRA) * Ethylene glycol intoxication * Infections ** Clostridium difficile ** Tuberculosis ** Pertussis ** Infectious mononucleosis (lymphocyte predominant) ** Visceral larva migrans (eosinophil predominant) * Asplenia * Diabetic ketoacidosis * Organ necrosis ** Hepatic necrosis ** Isch ...
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Acute (medicine)
In medicine, describing a disease as acute denotes that it is of short duration and, as a corollary of that, of recent onset. The quantification of how much time constitutes "short" and "recent" varies by disease and by context, but the core denotation of "acute" is always qualitatively in contrast with " chronic", which denotes long-lasting disease (for example, in acute leukaemia and chronic leukaemia). In addition, "acute" also often connotes two other meanings: sudden onset and severity, such as in acute myocardial infarction (AMI), where suddenness and severity are both established aspects of the meaning. It thus often connotes that the condition is fulminant (as in the AMI example), but not always (as in acute rhinitis, which is usually synonymous with the common cold). The one thing that acute MI and acute rhinitis have in common is that they are not chronic. They can happen again (as in recurrent pneumonia, that is, multiple acute pneumonia episodes), but they ar ...
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Exothrix
Exothrix refers to Dermatophyte infections of the hair that infect the hair surface. This is in contrast to Endothrix, where a Dermatophyte mainly invades the hair shaft. Using an ultraviolet Wood's lamp, endothrix infections will not fluoresce Fluorescence is the emission of light by a substance that has absorbed light or other electromagnetic radiation. It is a form of luminescence. In most cases, the emitted light has a longer wavelength, and therefore a lower photon energy, tha ... whereas exothrix infections will. References * Animal fungal diseases {{disease-stub ...
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Tinea Corporis
Tinea corporis is a fungal infection of the body, similar to other forms of tinea. Specifically, it is a type of dermatophytosis (or ringworm) that appears on the arms and legs, especially on glabrous skin; however, it may occur on any superficial part of the body. Signs and symptoms It may have a variety of appearances; most easily identifiable are the enlarging raised red rings with a central area of clearing (ringworm). The same appearances of ringworm may also occur on the scalp (tinea capitis), beard area (tinea barbae) or the groin (tinea cruris, known as jock itch or dhobi itch). Other classic features of tinea corporis include: * Itching occurs on infected area. * The edge of the rash appears elevated and is scaly to touch. * Sometimes the skin surrounding the rash may be dry and flaky. * Almost invariably, there will be hair loss in areas of the infection. Causes Tinea corporis is caused by a tiny fungus known as dermatophyte. These tiny organisms normally live on the su ...
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