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Medicinal Molds
Medicinal fungi are fungi that contain metabolites or can be induced to produce metabolites through biotechnology to develop prescription drugs. Compounds successfully developed into drugs or under research include antibiotics, anti-cancer drugs, cholesterol and ergosterol synthesis inhibitors, psychotropic drugs, immunosuppressants and fungicides. History Although fungi products have long been used in traditional medicine, the ability to identify beneficial properties and then extract the active ingredient started with the discovery of penicillin by Alexander Fleming in 1928. Since that time, many potential antibiotics were discovered and the potential for various fungi to synthesize biologically active molecules useful in various clinical therapies has been under research. Pharmacological research identified antifungal, antiviral, and antiprotozoan compounds from fungi. ''Ganoderma lucidum'', known in Chinese as líng zhī ("spirit plant"), and in Japanese as mannentake ("10,0 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fungi
A fungus ( : fungi or funguses) is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and molds, as well as the more familiar mushrooms. These organisms are classified as a kingdom, separately from the other eukaryotic kingdoms, which by one traditional classification include Plantae, Animalia, Protozoa, and Chromista. A characteristic that places fungi in a different kingdom from plants, bacteria, and some protists is chitin in their cell walls. Fungi, like animals, are heterotrophs; they acquire their food by absorbing dissolved molecules, typically by secreting digestive enzymes into their environment. Fungi do not photosynthesize. Growth is their means of mobility, except for spores (a few of which are flagellated), which may travel through the air or water. Fungi are the principal decomposers in ecological systems. These and other differences place fungi in a single group of related organisms, named the ''Eumycota'' (''t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antiviral Drug
Antiviral drugs are a class of medication used for treating viral infections. Most antivirals target specific viruses, while a broad-spectrum antiviral is effective against a wide range of viruses. Unlike most antibiotics, antiviral drugs do not destroy their target pathogen; instead they inhibit its development. Antiviral drugs are one class of antimicrobials, a larger group which also includes antibiotic (also termed antibacterial), antifungal and antiparasitic drugs, or antiviral drugs based on monoclonal antibodies. Most antivirals are considered relatively harmless to the host, and therefore can be used to treat infections. They should be distinguished from viricides, which are not medication but deactivate or destroy virus particles, either inside or outside the body. Natural viricides are produced by some plants such as eucalyptus and Australian tea trees. Medical uses Most of the antiviral drugs now available are designed to help deal with HIV, herpes viruses, th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Podophyllotoxin
Podophyllotoxin (PPT) is the active ingredient in Podofilox, which is a medical cream that is used to treat genital warts and molluscum contagiosum. It is not recommended in HPV infections without external warts. It can be applied either by a healthcare provider or the person themselves. It is a non-alkaloid toxin lignin extracted from the roots and rhizomes of '' Podophyllum'' species. A less refined form known as podophyllum resin is also available, but has greater side effects. Podophyllotoxin was first isolated in pure form in 1880 by Valerian Podwyssotzki (1818 – 28 January 1892), a Polish-Russian privatdozent at the University of Dorpat (now: Tartu, Estonia) and assistant at the Pharmacological Institute there. It is on the World Health Organization's List of Essential Medicines. Medical uses Podophyllotoxin possesses a large number of medical applications, as it is able to stop replication of both cellular and viral DNA by binding necessary enzymes. It can addi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vincristine
Vincristine, also known as leurocristine and marketed under the brand name Oncovin among others, is a chemotherapy medication used to treat a number of types of cancer. This includes acute lymphocytic leukemia, acute myeloid leukemia, Hodgkin's disease, neuroblastoma, and small cell lung cancer among others. It is given intravenously. Most people experience some side effects from vincristine treatment. Commonly it causes a change in sensation, hair loss, constipation, difficulty walking, and headaches. Serious side effects may include neuropathic pain, lung damage, or low white blood cells which increases the risk of infection. Use during pregnancy may result in birth defects. It works by stopping cells from dividing properly. It is vital that it not be given intrathecally, as this causes paralysis and in most cases, death. Vincristine was first isolated in 1961. It is on the World Health Organization's List of Essential Medicines. It is a vinca alkaloid that can be obtaine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vinblastine
Vinblastine (VBL), sold under the brand name Velban among others, is a chemotherapy medication, typically used with other medications, to treat a number of types of cancer. This includes Hodgkin's lymphoma, non-small cell lung cancer, bladder cancer, brain cancer A brain tumor occurs when abnormal cells form within the brain. There are two main types of tumors: malignant tumors and benign (non-cancerous) tumors. These can be further classified as primary tumors, which start within the brain, and second ..., melanoma, and testicular cancer. It is given by intravenous, injection into a vein. Most people experience some side effects. Commonly it causes a change in sensation, constipation, weakness, loss of appetite, and headaches. Severe side effects include cytopenia, low blood cell counts and shortness of breath. It should not be given to people who have a current bacterial infection. Use during pregnancy will likely harm the baby. Vinblastine works by mitotic inhibitor, bl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mitotic Inhibitor
A mitotic inhibitor is a drug that inhibits mitosis, or cell division. These drugs disrupt microtubules, which are structures that pull the chromosomes apart when a cell divides. Mitotic inhibitors are used in cancer treatment, because cancer cells are able to grow and eventually spread through the body (metastasize) through continuous mitotic division. Thus, cancer cells are more sensitive to inhibition of mitosis than normal cells. Mitotic inhibitors are also used in cytogenetics (the study of chromosomes), where they stop cell division at a stage where chromosomes can be easily examined. Mitotic inhibitors are derived from natural substances such as plant alkaloids, and prevent cells from undergoing mitosis by disrupting microtubule polymerization, thus preventing cancerous growth. Microtubules are long, ropelike proteins that extend through the cell and move cellular components around. Microtubules are long polymers made of smaller units (monomers) of the protein tubulin. Micro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paclitaxel
Paclitaxel (PTX), sold under the brand name Taxol among others, is a chemotherapy medication used to treat a number of types of cancer. This includes ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer. It is administered by intravenous injection. There is also an albumin-bound formulation. Common side effects include hair loss, bone marrow suppression, numbness, allergic reactions, muscle pains, and diarrhea. Other serious side effects include heart problems, increased risk of infection, and lung inflammation. There are concerns that use during pregnancy may cause birth defects. Paclitaxel is in the taxane family of medications. It works by interference with the normal function of microtubules during cell division. Paclitaxel was first isolated in 1971 from the Pacific yew and approved for medical use in 1993. It is on the World Health Organization's List of Essential Medicines. It has been made from ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer Ward
''Cancer Ward'' (russian: links=no, italics=yes, Раковый корпус, Rakovy korpus) is a semi-autobiographical novel by Nobel Prize-winning Russian author Aleksandr Solzhenitsyn. Completed in 1966, the novel was distributed in Russia that year in ''samizdat'', and banned there the following year.Joseph Pearce, ''Solzhenitsyn: A Soul in Exile'', Ignatius Press, 2011, p. 184ff.Patricia Blake"A Diseased Body Politic" ''The New York Times'', 27 October 1968. In 1968, several European publishers published it in Russian, and in April 1968, excerpts in English appeared in the ''Times Literary Supplement'' in the UK without Solzhenitsyn's permission."Cancer Ward" ''Encyclopædia Britannica.'' An unauthorized English translation was published that year, first by The Bodley Head in the UK, then by Dial Press ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alexandr Solzhenitsyn
Aleksandr Isayevich Solzhenitsyn. (11 December 1918 – 3 August 2008) was a Russian novelist. One of the most famous Soviet dissidents, Solzhenitsyn was an outspoken critic of communism and helped to raise global awareness of political repression in the Soviet Union, in particular the Gulag system. Solzhenitsyn was born into a family that defied the Soviet anti-religious campaign in the 1920s and remained devout members of the Russian Orthodox Church. While still young, Solzhenitsyn lost his faith in Christianity, became an atheist, and embraced Marxism–Leninism. While serving as a captain in the Red Army during World War II, Solzhenitsyn was arrested by the SMERSH and sentenced to eight years in the Gulag and then internal exile for criticizing Soviet leader Joseph Stalin in a private letter. As a result of his experience in prison and the camps, he gradually became a philosophically-minded Eastern Orthodox Christian. As a result of the Khrushchev Thaw, Solzhenitsyn was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inonotus Obliquus
''Inonotus obliquus'', commonly called chaga (a Latinisation of the Russian word ''чага''), is a fungus in the family Hymenochaetaceae. It is parasitic on birch and other trees. The sterile conk is irregularly formed and resembles burnt charcoal. It is not the fruiting body of the fungus, but a sclerotium or mass of mycelium, mostly black because of a great amount of melanin. Some people consider chaga medicinal. ''Inonotus obliquus'' is found most commonly in the Circumboreal Region of the Northern Hemisphere, where it is distributed in birch forests. Common names The name ''chaga'' () comes from the Russian name of the fungus, russian: чага, translit=čaga, label=none, which in turn is borrowed from the word for "mushroom" in Komi, kv, тшак, translit=tšak, label=none, the language of the indigenous peoples in the Kama River Basin, west of the Ural Mountains. It is also known as the clinker polypore, cinder conk, black mass and birch canker polypore. In En ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ganoderma Applanatum
''Ganoderma applanatum'' (the artist's bracket, artist's conk, artist's fungus or bear bread) is a bracket fungus with a cosmopolitan distribution. Description This fungus is parasitic and saprophytic, and grows as a mycelium within the wood of living and dead trees. The ''Ganoderma applanatum'' grows in single, scattered, or compound formations. It forms fruiting bodies that are 3–30 cm wide × 5–50 cm long × 1–10 cm thick, hard as leather, woody-textured, and inedible. They are white at first but soon turn dark red-brown. The upper surface of the fruiting body is covered with reddish brown conidia. Brown spores are released from the pores on the underside of the fruiting body. The spores are highly concentrated, and as many as 4.65 billion spores can be dispersed from a 10–10 cm section of the conk within 24 hours. The tubes are 4–12 mm deep and terminate in pores that are round with 4–6 per millimetre. The fruiting bodies are perennial, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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