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Laser Doppler Imaging
Laser Doppler imaging (LDI) is an imaging method that uses a laser beam to image live tissue. When the laser light reaches the tissue, the moving blood cells generate Doppler components in the reflected ( backscattered) light. The light that comes back is detected using a photodiode that converts it into an electrical signal. Then the signal is processed to calculate a signal that is proportional to the tissue perfusion in the imaged area. When the process is completed, the signal is processed to generate an image that shows the perfusion on a screen. The laser Doppler effect was first used to measure microcirculation by Stern M.D. in 1975. It is used widely in medicine, some representative research work about it are these: Use in ophthalmology The eye offers a unique opportunity for the non-invasive exploration of cardiovascular diseases. LDI by digital holography can measure blood flow in the retina and choroid. In particular, the choroid is a highly vascularized tissue supply ...
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Microangiography
Microangiography ( ) is a type of angiography that consists of the radiography of small blood or lymphatic vessels of an organ. While most other types of angiography cannot produce images of vessels smaller than 200 μm in diameter, microangiography does just that. A microangiographic image is the result of injection of a contrast medium into either the blood or the lymphatic system and, then, enlargement of the resulting radiograph. Thus, an image is obtained in which there is contrast between vessel and surrounding tissue. It is often used in order to detect microvascular lesions in organs. But, it has been suggested that microangiography can also be used to detect tumors through visualization of tumor-induced small blood vessels. This is because tumor growths require vascularization before they can develop more rapidly. A few of the commonly used types are fluorescent, silicone rubber, and synchrotron radiation microangiography. Common types Fluorescent microangiography ...
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Diastole
Diastole ( ) is the relaxed phase of the cardiac cycle when the chambers of the heart are refilling with blood. The contrasting phase is systole when the heart chambers are contracting. Atrial diastole is the relaxing of the atria, and ventricular diastole the relaxing of the ventricles. The term originates from the Greek word (''diastolē''), meaning "dilation", from (''diá'', "apart") + (''stéllein'', "to send"). Role in cardiac cycle A typical heart rate is 75 beats per minute (bpm), which means that the cardiac cycle that produces one heartbeat, lasts for less than one second. The cycle requires 0.3 sec in ventricular systole (contraction)—pumping blood to all body systems from the two ventricles; and 0.5 sec in diastole (dilation), re-filling the four chambers of the heart, for a total of 0.8 sec to complete the cycle. Early ventricular diastole During early ventricular diastole, pressure in the two ventricles begins to drop from the peak reached during systole ...
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Laser Surface Velocimeter
A laser surface velocimeter (LSV) is a non-contact optical speed sensor measuring velocity and length on moving surfaces. Laser surface velocimeters use the laser Doppler principle to evaluate the laser light scattered back from a moving object. They are widely used for process and quality control in industrial production processes. According to J. Cimbala, in the case of laser Doppler velocimeter, the use of the term Doppler is a misnomer because no Doppler shift measurement is involved in the technique. Principle of operation The differential Doppler process The Doppler effect (or Doppler shift) is the change in frequency of a wave for an observer An observer is one who engages in observation or in watching an experiment. Observer may also refer to: Fiction * ''Observer'' (novel), a 2023 science fiction novel by Robert Lanza and Nancy Kress * ''Observer'' (video game), a cyberpunk horr ... moving relative to the source of the wave. The wave has a frequency f and propagat ...
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Laser Doppler Vibrometer
A laser Doppler vibrometer (LDV) is a scientific instrument that is used to make non-contact vibration measurements of a surface. The laser beam from the LDV is directed at the surface of interest, and the vibration amplitude and frequency are extracted from the Doppler shift of the reflected laser beam frequency due to the motion of the surface. The output of an LDV is generally a continuous analog voltage that is directly proportional to the target velocity component along the direction of the laser beam. Some advantages of an LDV over similar measurement devices such as an accelerometer are that the LDV can be directed at targets that are difficult to access, or that may be too small or too hot to attach a physical transducer. Also, the LDV makes the vibration measurement without mass-loading the target, which is especially important for MEMS devices. Principles of operation A vibrometer is generally a two beam laser interferometer that measures the frequency (or phase) diffe ...
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Laser Doppler Velocimetry
Laser Doppler velocimetry, also known as laser Doppler anemometry, is the technique of using the Doppler shift in a laser beam to measure the velocity in transparent or semi-transparent fluid flows or the linear or vibratory motion of opaque, reflecting surfaces. The measurement with laser Doppler anemometry is absolute and linear with velocity and requires no pre-calibration. Technology origin The development of the helium–neon laser (He-Ne) in 1962 at the Bell Telephone Laboratories provided the optics community with a continuous wave electromagnetic radiation source that was highly concentrated at a wavelength of 632.8 nanometers (nm) in the red portion of the visible spectrum. It was discovered that fluid flow measurements could be made using the Doppler effect on a He-Ne beam scattered by small polystyrene spheres in the fluid. At the Research Laboratories of Brown Engineering Company (later Teledyne Brown Engineering), this phenomenon was used to develop the first laser D ...
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Hot-wire Anemometry
In meteorology, an anemometer () is a device that measures wind speed and direction. It is a common instrument used in weather stations. The earliest known description of an anemometer was by Italian architect and author Leon Battista Alberti (1404–1472) in 1450. History The anemometer has changed little since its development in the 15th century. Alberti is said to have invented it around 1450. In the ensuing centuries numerous others, including Robert Hooke (1635–1703), developed their own versions, with some mistakenly credited as its inventor. In 1846, Thomas Romney Robinson (1792–1882) improved the design by using four hemispherical cups and mechanical wheels. In 1926, Canadian meteorologist John Patterson (1872–1956) developed a three-cup anemometer, which was improved by Brevoort and Joiner in 1935. In 1991, Derek Weston added the ability to measure wind direction. In 1994, Andreas Pflitsch developed the sonic anemometer. Velocity anemometers Cup anemometers ...
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Vasocongestion
Vasocongestion, vascular congestion or vascular engorgement is the swelling of bodily tissues caused by increased vascular blood flow and a localized increase in blood pressure. Typical causes of vasocongestion in humans includes menstruation, sexual arousal, REM sleep, strong emotions, illnesses, deep venous thrombosis (DVT) and allergic reactions. Illnesses Menstrual cramps are one of the most common side effects of vasocongestion in adult females. Although pain and discomfort varies among individuals, vasocongestion is an essential part of the shedding of the lining of the uterus. Abnormal vasocongestion during the menstrual cycle can lead to irregular bleeding, severe and debilitating cramps and anemia caused by increased menstrual flow. The temporary vasocongestion of the cheeks of the face is called blushing. It may be caused by the emotions of anger or embarrassment. The illness of rosacea is a chronic vasocongestion condition of the face that primarily affects the cheeks a ...
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Vaginal Photoplethysmograph
Vaginal photoplethysmography (VPG, VPP) is a technique using light to measure the amount of blood in the walls of the vagina. The device that is used is called a vaginal photometer. Use The device is used to try to obtain an objective measure of a woman's sexual arousal. There is an overall poor correlation (r = 0.26) between women's self-reported levels of desire and their VPG readings. Instrument The instrument used in the procedure is called vaginal photometer. The device has a clear shell, inside of which is a light source and a photocell, which senses reflected light. The use of the device is done with the assumption that the more light that is scattered back, and that the photocell senses, the more blood is in the walls of the vagina. The output of the VPG can be filtered into two types of signals, which have different properties. The direct current signal is a measure of vaginal blood volume (VBV) and reflects the total blood volume in the vaginal tissues.Hatch, J. P. ...
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Discriminant Validity
In psychology, discriminant validity tests whether concepts or measurements that are not supposed to be related are actually unrelated. Campbell and Fiske (1959) introduced the concept of discriminant validity within their discussion on evaluating test validity. They stressed the importance of using both discriminant and convergent validation techniques when assessing new tests. A successful evaluation of discriminant validity shows that a test of a concept is not highly correlated with other tests designed to measure theoretically different concepts. In showing that two scales do not correlate, it is necessary to correct for attenuation In physics, attenuation (in some contexts, extinction) is the gradual loss of flux intensity through a Transmission medium, medium. For instance, dark glasses attenuate sunlight, lead attenuates X-rays, and water and air attenuate both light and ... in the correlation due to measurement error. It is possible to calculate the extent to which the ...
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Construct Validity
Construct validity concerns how well a set of indicators represent or reflect a concept that is not directly measurable. ''Construct validation'' is the accumulation of evidence to support the interpretation of what a measure reflects.Polit DF Beck CT (2012). Nursing Research: Generating and Assessing Evidence for Nursing Practice, 9th ed. Philadelphia, USA: Wolters Klower Health, Lippincott Williams & Wilkins Modern validity theory defines construct validity as the overarching concern of validity research, subsuming all other types of validity evidence such as content validity and criterion validity. Construct validity is the appropriateness of inferences made on the basis of observations or measurements (often test scores), specifically whether a test can reasonably be considered to reflect the intended construct. Constructs are abstractions that are deliberately created by researchers in order to conceptualize the latent variable, which is correlated with scores on a given me ...
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Principal Component Analysis
Principal component analysis (PCA) is a linear dimensionality reduction technique with applications in exploratory data analysis, visualization and data preprocessing. The data is linearly transformed onto a new coordinate system such that the directions (principal components) capturing the largest variation in the data can be easily identified. The principal components of a collection of points in a real coordinate space are a sequence of p unit vectors, where the i-th vector is the direction of a line that best fits the data while being orthogonal to the first i-1 vectors. Here, a best-fitting line is defined as one that minimizes the average squared perpendicular distance from the points to the line. These directions (i.e., principal components) constitute an orthonormal basis in which different individual dimensions of the data are linearly uncorrelated. Many studies use the first two principal components in order to plot the data in two dimensions and to visually identi ...
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Pulse
In medicine, the pulse refers to the rhythmic pulsations (expansion and contraction) of an artery in response to the cardiac cycle (heartbeat). The pulse may be felt ( palpated) in any place that allows an artery to be compressed near the surface of the body close to the skin, such as at the neck ( carotid artery), wrist (radial artery or ulnar artery), at the groin (femoral artery), behind the knee ( popliteal artery), near the ankle joint ( posterior tibial artery), and on foot (dorsalis pedis artery). The pulse is most commonly measured at the wrist or neck for adults and at the brachial artery (inner upper arm between the shoulder and elbow) for infants and very young children. A sphygmograph is an instrument for measuring the pulse. Physiology Claudius Galen was perhaps the first physiologist to describe the pulse. The pulse is an expedient tactile method of determination of systolic blood pressure to a trained observer. Diastolic blood pressure is non-palpable and ...
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