Kefah Mokbel
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Kefah Mokbel
Professor Kefah Mokbel FRCS is the lead consultant breast surgeon at the London Breast Institute of the Princess Grace Hospital, Professor (Honorary) of Breast Cancer Surgery at Brunel University London, an honorary consultant breast surgeon at St George's Hospital. Kefah Mokbel is the founder and current president of Breast Cancer Hope; a UK-based charity "dedicated to improving the quantity and quality of life in women diagnosed with breast cancer". He was appointed as a substantive consultant breast surgeon at St George's Hospital NHS trust in February 2001. He was named in Tatler (1901), Tatler magazine's Best Doctors Guide as one of the featured "Top Breast Surgeons" in 2006, 2007 and 2013. In November 2010 he was named in the Times magazine's list of Britain's Top Doctors. Personal details and education Kefah Mokbel was born in 1965 in the currently occupied Golan Heights in Syria. At the end of junior high school, he was awarded a national scholarship after he passed the ...
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Concord College, Acton Burnell
Concord College is an independent co-educational international day/ boarding school in Shropshire, England situated in the grounds of Acton Burnell Castle. The college admits students aged between 12 and 19; the majority of whom come from overseas. Concord College excels in academic results with an 85% A*-A at A-level and 82% A*-A at GCSE level. In 2009, to celebrate its 60th year, Concord was visited by the Princess Royal. History The main building of Concord College is Acton Burnell Hall, the manor house of Acton Burnell Castle. Ranking In 2016, The Times league table for independent co-educational schools in the UK placed Concord tenth in the UK. In 2022, The Telegraph ranked Concord College's A-level results as 16th amongst all UK independent schools, and 7th for those which offer boarding. Notable former pupils * Marty Natalegawa, Indonesian Minister of Foreign Affairs * Zeinal Bava, telecoms entrepreneur * Bowie Cheung ( 張寶兒), Hong Kong presenter and actress, ...
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Brunel University
Brunel University London is a public research university located in the Uxbridge area of London, England. It was founded in 1966 and named after the Victorian engineer and pioneer of the Industrial Revolution, Isambard Kingdom Brunel. In June 1966, Brunel College of Advanced Technology was awarded a royal charter and became Brunel University. The university is often described as a British plate glass university. Brunel is organised into three colleges, a structure adopted in August 2014 which also changed the university's name to Brunel University London. Brunel has over 16,150 students and 2,500 staff, and had a total income of £237 million in 2019–20, of which 30% came from grants and research contracts. Brunel has three constituent Academic Colleges: the College of Business, Arts and Social Sciences; the College of Engineering, Design and Physical Sciences; and the College of Health, Medicine and Life Sciences. Brunel is a member of the Association of Commonwealth Universi ...
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The Daily Telegraph
''The Daily Telegraph'', known online and elsewhere as ''The Telegraph'', is a national British daily broadsheet newspaper published in London by Telegraph Media Group and distributed across the United Kingdom and internationally. It was founded by Arthur B. Sleigh in 1855 as ''The Daily Telegraph & Courier''. Considered a newspaper of record over ''The Times'' in the UK in the years up to 1997, ''The Telegraph'' generally has a reputation for high-quality journalism, and has been described as being "one of the world's great titles". The paper's motto, "Was, is, and will be", appears in the editorial pages and has featured in every edition of the newspaper since 19 April 1858. The paper had a circulation of 363,183 in December 2018, descending further until it withdrew from newspaper circulation audits in 2019, having declined almost 80%, from 1.4 million in 1980.United Newspapers PLC and Fleet Holdings PLC', Monopolies and Mergers Commission (1985), pp. 5–16. Its si ...
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The Times
''The Times'' is a British daily national newspaper based in London. It began in 1785 under the title ''The Daily Universal Register'', adopting its current name on 1 January 1788. ''The Times'' and its sister paper ''The Sunday Times'' (founded in 1821) are published by Times Newspapers, since 1981 a subsidiary of News UK, in turn wholly owned by News Corp. ''The Times'' and ''The Sunday Times'', which do not share editorial staff, were founded independently and have only had common ownership since 1966. In general, the political position of ''The Times'' is considered to be centre-right. ''The Times'' is the first newspaper to have borne that name, lending it to numerous other papers around the world, such as ''The Times of India'', ''The New York Times'', and more recently, digital-first publications such as TheTimesBlog.com (Since 2017). In countries where these other titles are popular, the newspaper is often referred to as , or as , although the newspaper is of nationa ...
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The Lancet
''The Lancet'' is a weekly peer-reviewed general medical journal and one of the oldest of its kind. It is also the world's highest-impact academic journal. It was founded in England in 1823. The journal publishes original research articles, review articles ("seminars" and "reviews"), editorials, book reviews, correspondence, as well as news features and case reports. ''The Lancet'' has been owned by Elsevier since 1991, and its editor-in-chief since 1995 has been Richard Horton. The journal has editorial offices in London, New York City, and Beijing. History ''The Lancet'' was founded in 1823 by Thomas Wakley, an English surgeon who named it after the surgical instrument called a lancet (scalpel). Members of the Wakley family retained editorship of the journal until 1908. In 1921, ''The Lancet'' was acquired by Hodder & Stoughton. Elsevier acquired ''The Lancet'' from Hodder & Stoughton in 1991. Impact According to the ''Journal Citation Reports'', the journal has a 202 ...
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SETD2
SET domain containing 2 is an enzyme that in humans is encoded by the ''SETD2'' gene. Function SETD2 protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. The trimethylation of lysine-36 of histone H3 ( H3K36me3) is required in human cells for homologous recombinational repair and genome stability. Depletion of SETD2 increases the frequency of deletion mutations that arise by the alternative DNA repair process of microhomology-mediated end joining. Clinical significance The SETD2 gene is located on the short arm of chromosome 3 and has been shown to play a tumour suppressor role in human cancer. Interactions SETD2 has been shown to interact with Huntingtin. Huntington's disease (HD), a neurodegenerative disorder characterized by lo ...
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I10-index
Author-level metrics are citation metrics that measure the bibliometrics, bibliometric impact of individual authors, researchers, academics, and scholars. Many metrics have been developed that take into account varying numbers of factors (from only considering the total number of citations, to looking at their distribution across papers or Academic journal, journals using statistical or Graph theory, graph-theoretic principles). The main motivation for these quantitative comparisons between researchers is to allocate resources (e.g. funding, academic appointments). However, there remains controversy in the academic community as to how well author-level metrics achieve this goal. Author-level metrics differ from journal-level metrics which attempt to measure the bibliometric impact of academic journals rather than individuals. However, metrics originally developed for academic journals can be reported at researcher level, such as the author-level eigenfactor and the author impact f ...
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H-index
The ''h''-index is an author-level metric that measures both the productivity and citation impact of the publications, initially used for an individual scientist or scholar. The ''h''-index correlates with obvious success indicators such as winning the Nobel Prize, being accepted for research fellowships and holding positions at top universities. The index is based on the set of the scientist's most cited papers and the number of citations that they have received in other publications. The index has more recently been applied to the productivity and impact of a scholarly journal as well as a group of scientists, such as a department or university or country. The index was suggested in 2005 by Jorge E. Hirsch, a physicist at UC San Diego, as a tool for determining theoretical physicists' relative quality and is sometimes called the Hirsch index or Hirsch number. Definition and purpose The ''h''-index is defined as the maximum value of ''h'' such that the given author/journa ...
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Google Scholar
Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines. Released in beta in November 2004, the Google Scholar index includes peer-reviewed online academic journals and books, conference papers, theses and dissertations, preprints, abstracts, technical reports, and other scholarly literature, including court opinions and patents. Google Scholar uses a web crawler, or web robot, to identify files for inclusion in the search results. For content to be indexed in Google Scholar, it must meet certain specified criteria. An earlier statistical estimate published in PLOS One using a mark and recapture method estimated approximately 80–90% coverage of all articles published in English with an estimate of 100 million.''Trend Watch'' (2014) Nature 509(7501), 405 – discussing Madian Khabsa and C Lee Giles (2014''The Number of Scholarly Documents on the Public Web'' ...
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Mastopexy
Mastopexy (Greek μαστός ''mastos'' "breast" + -pēxiā "affix") is the plastic surgery mammoplasty procedure for raising sagging breasts upon the chest of the woman, by changing and modifying the size, contour, and elevation of the breasts. In a breast-lift surgery to re-establish an aesthetically proportionate bust for the woman, the critical corrective consideration is the tissue viability of the nipple-areola complex (NAC), to ensure the functional sensitivity of the breasts for lactation and breast-feeding. The breast-lift correction of a sagging bust is a surgical operation that cuts and removes excess tissues (glandular, adipose, skin), overstretched suspensory ligaments, excess skin from the skin-envelope, and transposes the nipple-areola complex higher upon the breast hemisphere. In surgical practice, mastopexy can be performed as a discrete breast-lift procedure, and as a subordinate surgery within a combined mastopexy–breast augmentation procedure. Moreover, ...
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Fibroadenoma
Fibroadenomas are benign breast tumours characterized by an admixture of stromal and epithelial tissue. Breasts are made of lobules (milk producing glands) and ducts (tubes that carry the milk to the nipple). These are surrounded by glandular, fibrous and fatty tissues. Fibroadenomas develop from the lobules. The glandular tissue and ducts grow over the lobule to form a solid lump. Since both fibroadenomas and breast lumps as a sign of breast cancer can appear similar, it is recommended to perform ultrasound analyses and possibly tissue sampling with subsequent histopathologic analysis in order to make a proper diagnosis. Unlike typical lumps from breast cancer, fibroadenomas are easy to move, with clearly defined edges. Fibroadenomas are sometimes called breast mice or a breast mouse owing to their high mobility in the breast. Signs and symptoms Fibroadenomas are benign tumours of the breast, most often present in women in their 20s and 30s. Clinically, fibroadenomas are u ...
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Mastalgia
Breast pain is the symptom of discomfort in either one or both breasts. Pain in both breasts is often described as ''breast tenderness'', is usually associated with the menstrual period and is not serious. Pain that involves only one part of a breast is more concerning, particularly if a hard breast mass, mass or nipple discharge is also present. Causes may be related to the menstrual cycle, birth control pills, hormone therapy, or psychiatric medication. Pain may also occur in those with large breasts, during menopause, and in early pregnancy. In about 2% of cases breast pain is related to breast cancer. Diagnosis involves breast examination, examination, with medical imaging if only a specific part of the breast hurts. In more than 75% of people the pain resolves without any specific treatment. Otherwise treatments may include paracetamol or NSAIDs. A well fitting bra may also help. In those with severe pain tamoxifen or danazol may be used. About 70% of women have breast pai ...
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