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Junin Virus
''Argentinian mammarenavirus'', better known as the ''Junin virus'' or ''Junín virus'' (JUNV), is an arenavirus in the '' Mammarenavirus'' genus that causes Argentine hemorrhagic fever (AHF). The virus took its original name from the city of Junín, around which the first cases of infection were reported, in 1958. Virology Structure ''Argentinian mammarenavirus'' is a negative sense ssRNA enveloped virion with a variable diameter between 50 and 300  nm. The surface of the particle encompasses a layer of T-shaped glycoproteins, each extending up to 10 nm outwards from the envelope, which are important in mediating attachment and entry into host cells. Genome The ''Argentinian mammarenavirus'' genome is composed of two single-stranded RNA molecules, each encoding two different genes in an ambisense orientation. The two segments are termed 'short (S)' and 'long (L)' owing to their respective lengths. The short segment (around 3400 nucleotides in length) encodes ...
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Transmission Electron Micrograph
Transmission electron microscopy (TEM) is a microscopy technique in which a beam of electrons is transmitted through a specimen to form an image. The specimen is most often an ultrathin section less than 100 nm thick or a suspension on a grid. An image is formed from the interaction of the electrons with the sample as the beam is transmitted through the specimen. The image is then magnified and focused onto an imaging device, such as a fluorescent screen, a layer of photographic film, or a sensor such as a scintillator attached to a charge-coupled device. Transmission electron microscopes are capable of imaging at a significantly higher resolution than light microscopes, owing to the smaller de Broglie wavelength of electrons. This enables the instrument to capture fine detail—even as small as a single column of atoms, which is thousands of times smaller than a resolvable object seen in a light microscope. Transmission electron microscopy is a major analytical method i ...
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Nervous System
In biology, the nervous system is the highly complex part of an animal that coordinates its actions and sensory information by transmitting signals to and from different parts of its body. The nervous system detects environmental changes that impact the body, then works in tandem with the endocrine system to respond to such events. Nervous tissue first arose in wormlike organisms about 550 to 600 million years ago. In vertebrates it consists of two main parts, the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS consists of the brain and spinal cord. The PNS consists mainly of nerves, which are enclosed bundles of the long fibers or axons, that connect the CNS to every other part of the body. Nerves that transmit signals from the brain are called motor nerves or '' efferent'' nerves, while those nerves that transmit information from the body to the CNS are called sensory nerves or '' afferent''. Spinal nerves are mixed nerves that serve ...
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Azara's Grass Mouse
''Akodon azarae'', also known as Azara's akodontMusser and Carleton, 2005, p. 1093 or Azara's grass mouse, is a rodent species from South America. It is found from southernmost Brazil through Paraguay and Uruguay into eastern Argentina. It is named after Spanish people, Spanish Natural history, naturalist Félix de Azara. References Literature cited *D'Elia, G. and Pardinas, U. 2008. . In IUCN. IUCN Red List of Threatened Species. Version 2009.2.www.iucnredlist.org. Downloaded on April 2, 2010. *Musser, G.G. and Carleton, M.D. 2005Superfamily Muroidea Pp. 894–1531 in Wilson, D.E. and Reeder, D.M. (eds.)Mammal Species of the World: a taxonomic and geographic reference. 3rd ed
Baltimore: The Johns Hopkins University Press, 2 vols., 2142 pp. Mammals of Argentina Mammals of Brazil Mammals of Paraguay Mammals of Uruguay Rodents of South America Akodon Mammals described in 1829 Stored-product pests Taxa named by Johann Baptist Fischer {{Akodon-stub ...
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Vesper Mouse
Vesper mice are rodents belonging to a genus ''Calomys''. They are widely distributed in South America. Some species are notable as the vectors of Argentinian hemorrhagic fever and Bolivian hemorrhagic fever. The genus was originally named ''Hesperomys'', but was changed to ''Calomys'' since 1962. History ''Hesperomys'' was introduced by George Robert Waterhouse in 1839 for the American rodents with cusps arranged in two series. The name combines the Greek ἑσπερος "west" and μυς "mouse". He considered it possible that species of ''Hesperomys'' would be found in the Old World, but did not doubt that the Americas were their chief abode. He included as species ''Mus bimaculatus'' (='' Calomys laucha''), ''Mus griseo-flavus'' (='' Graomys griseoflavus''), ''Mus Darwinii'' (='' Phyllotis darwini''), ''Mus zanthopygus'' (='' Phyllotis xanthopygus''), ''Mus galapagoensis'' (='' Aegialomys galapagoensis''), ''Symidon hispidum'' (='' Sigmodon hispidus''), ''Mus leucopus'' (=' ...
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House Mouse
The house mouse (''Mus musculus'') is a small mammal of the order Rodentia, characteristically having a pointed snout, large rounded ears, and a long and almost hairless tail. It is one of the most abundant species of the genus ''Mus''. Although a wild animal, the house mouse has benefited significantly from associating with human habitation to the point that truly wild populations are significantly less common than the semi-tame populations near human activity. The house mouse has been domesticated as the pet or fancy mouse, and as the laboratory mouse, which is one of the most important model organisms in biology and medicine. The complete mouse reference genome was sequenced in 2002. Characteristics House mice have an adult body length (nose to base of tail) of and a tail length of . The weight is typically . In the wild they vary in color from grey and light brown to black (individual hairs are actually agouti coloured), but domesticated fancy mice and laboratory mice ...
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Influenza
Influenza, commonly known as "the flu", is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptoms begin from one to four days after exposure to the virus (typically two days) and last for about 2–8 days. Diarrhea and vomiting can occur, particularly in children. Influenza may progress to pneumonia, which can be caused by the virus or by a subsequent bacterial infection. Other complications of infection include acute respiratory distress syndrome, meningitis, encephalitis, and worsening of pre-existing health problems such as asthma and cardiovascular disease. There are four types of influenza virus, termed influenza viruses A, B, C, and D. Aquatic birds are the primary source of Influenza A virus (IAV), which is also widespread in various mammals, including humans and pigs. Influenza B virus (IBV) and Influenza C virus (ICV) pr ...
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Sepsis
Sepsis, formerly known as septicemia (septicaemia in British English) or blood poisoning, is a life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. This initial stage is followed by suppression of the immune system. Common signs and symptoms include fever, increased heart rate, increased breathing rate, and confusion. There may also be symptoms related to a specific infection, such as a cough with pneumonia, or painful urination with a kidney infection. The very young, old, and people with a weakened immune system may have no symptoms of a specific infection, and the body temperature may be low or normal instead of having a fever. Severe sepsis causes poor organ function or blood flow. The presence of low blood pressure, high blood lactate, or low urine output may suggest poor blood flow. Septic shock is low blood pressure due to sepsis that does not improve after fluid replacement. Sepsis is caused ...
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Petechiae
A petechia () is a small red or purple spot (≤4 mm in diameter) that can appear on the skin, conjunctiva, retina, and mucous membranes which is caused by haemorrhage of capillaries. The word is derived from Italian , 'freckle,' of obscure origin. It refers to one of the three descriptive types of hematoma differentiated by size, the other two being ecchymosis (>1cm in diameter) and purpura (4-10mm in diameter). The term is always used in the plural (petechiae), since a single petechia is seldom noticed or significant. Causes Physical trauma The most common cause of petechiae is through physical trauma such as a hard bout of coughing, holding breath, vomiting, or crying, which can result in facial petechiae, especially around the eyes. Such instances are harmless and usually disappear within a few days. * Constriction, asphyxiation – petechiae, especially in the eyes, may also occur when excessive pressure is applied to tissue (e.g., when a tourniquet is applied to an extremi ...
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Purpura
Purpura () is a condition of red or purple discolored spots on the skin that do not blanch on applying pressure. The spots are caused by bleeding underneath the skin secondary to platelet disorders, vascular disorders, coagulation disorders, or other causes. They measure 3–10 mm, whereas petechiae measure less than 3 mm, and ecchymoses greater than 1 cm. Purpura is common with typhus and can be present with meningitis caused by meningococci or septicaemia. In particular, meningococcus (''Neisseria meningitidis''), a Gram-negative diplococcus organism, releases endotoxin when it lyses. Endotoxin activates the Hageman factor (clotting factor XII), which causes disseminated intravascular coagulation (DIC). The DIC is what appears as a rash on the affected individual. Classification Purpura are a common and nonspecific medical sign; however, the underlying mechanism commonly involves one of: * Platelet disorders (thrombocytopenic purpura) ** Primary thrombocyt ...
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Conjunctivitis
Conjunctivitis, also known as pink eye, is inflammation of the outermost layer of the white part of the eye and the inner surface of the eyelid. It makes the eye appear pink or reddish. Pain, burning, scratchiness, or itchiness may occur. The affected eye may have increased tears or be "stuck shut" in the morning. Swelling of the white part of the eye may also occur. Itching is more common in cases due to allergies. Conjunctivitis can affect one or both eyes. The most common infectious causes are viral followed by bacterial. The viral infection may occur along with other symptoms of a common cold. Both viral and bacterial cases are easily spread between people. Allergies to pollen or animal hair are also a common cause. Diagnosis is often based on signs and symptoms. Occasionally, a sample of the discharge is sent for culture. Prevention is partly by handwashing. Treatment depends on the underlying cause. In the majority of viral cases, there is no specific treatment. ...
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Virginia Tech
Virginia Tech (formally the Virginia Polytechnic Institute and State University and informally VT, or VPI) is a public land-grant research university with its main campus in Blacksburg, Virginia. It also has educational facilities in six regions statewide, a research center in Punta Cana, Dominican Republic, and a study-abroad site in Riva San Vitale, Switzerland. Through its Corps of Cadets ROTC program, Virginia Tech is a senior military college. Virginia Tech offers 280 undergraduate and graduate degree programs to some 34,400 students; as of 2015, it was the state's second-largest public university by enrollment. It manages a research portfolio of $522 million, placing it among the top 50 universities in the U.S. for total research expenditures, top 25 in computer and information sciences and top 10 in engineering, with the latter two the highest rankings in the state. It is classified among "R1: Doctoral Universities – Very high research activity". VT has produce ...
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