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Dopamine Receptor D4
The dopamine receptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the gene on chromosome 11 at 11p15.5. The structure of DRD4 was recently reported in complex with the antipsychotic drug nemonapride. As with other dopamine receptor subtypes, the D4 receptor is activated by the neurotransmitter dopamine. It is linked to many neurological and psychiatric conditions including schizophrenia and bipolar disorder, ADHD, addictive behaviors, Parkinson's disease, and eating disorders such as anorexia nervosa. A weak association has been drawn between DRD4 and borderline personality disorder. It is also a target for drugs which treat schizophrenia and Parkinson's disease. The D4 receptor is considered to be D2-like in which the activated receptor inhibits the enzyme adenylate cyclase, thereby reducing the intracellular concentration of the second messenger cyclic AMP. Genetics The human protein is coded by the ''DRD4'' on chromosome 11 located in 11p15.5. Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
D2-like Receptor
The D2-like receptors are a subfamily of dopamine receptors that bind the endogenous neurotransmitter dopamine. The D2-like subfamily consists of three G-protein coupled receptors that are coupled to Gi/Go and mediate inhibitory neurotransmission Neurotransmission (Latin: ''transmissio'' "passage, crossing" from ''transmittere'' "send, let through") is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron), ..., of which include D2, D3, and D4. For more information, please see the respective main articles of the individual subtypes: See also * D1-like receptor References Dopamine receptors {{transmembranereceptor-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gamma Wave
A gamma wave or gamma Rhythm is a pattern of neural oscillation in humans with a frequency between 25 and 140 Hz, the 40- Hz point being of particular interest. Gamma rhythms are correlated with large scale brain network activity and cognitive phenomena such as working memory, attention, and perceptual grouping, and can be increased in amplitude via meditation or neurostimulation. Altered gamma activity has been observed in many mood and cognitive disorders such as Alzheimer's disease, epilepsy, and schizophrenia. Discovery Gamma waves can be detected by electroencephalography or magnetoencephalography. One of the earliest reports of gamma wave activity was recorded from the visual cortex of awake monkeys. Subsequently, significant research activity has concentrated on gamma activity in visual cortex. Gamma activity has also been detected and studied across premotor, parietal, temporal, and frontal cortical regions Gamma waves constitute a common class of oscillatory a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Novelty Seeking
In Cloninger's model of psychobiology, novelty seeking (NS) is an inherited, unlearned, temperamental bias toward novel signals from the environment. It can be measured along a spectrum from low to high (as with 3 other temperamental domains) and when toward the upper end of the spectrum, it is associated with higher exploratory activity, need for higher levels of baseline stimulation, impulsive decision making, extravagance in approach to reward cues, quick temperedness, low tolerance for frustration, impulsivity, and proneness to addiction. It is measured in the Tridimensional Personality Questionnaire as well as the later version Temperament and Character Inventory and is considered one of the ''temperament'' dimensions of personality. Like the other temperament dimensions, it has been found to be highly heritable. High NS has been suggested to be related to low dopaminergic activity. In the revised version of the Temperament and Character Inventory (TCI-R) novelty seekin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Schizophrenia Research Forum
Schizophrenia Research Forum is a web knowledge environment dedicated to news, information resources, and discussion about research on schizophrenia. It hosts a number of resources such as What We Know About Schizophrenia, Animal Models and Drugs in Trials. It also hosts the ''SzGene'' database, an unbiased field synopsis of genetic association studies performed in schizophrenia, though this database is no longer updated. The Schizophrenia Forum was founded in 2005 by science editor Hakon Heimer as a project of the National Alliance for Research on Schizophrenia and Depression (now called the Brain & Behavior Research Foundation, with start-up funding from the National Institute of Mental Health and technical assistance from the Alzheimer Research Forum Alzheimer Research Forum (ARF), or Alzforum is a website which uses web technology to accelerate research into Alzheimer's disease. History The website was founded in 1996 by June Kinoshita, funded by an anonymous philanthropic f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SzGene
Schizophrenia Research Forum is a web knowledge environment dedicated to news, information resources, and discussion about research on schizophrenia. It hosts a number of resources such as What We Know About Schizophrenia, Animal Models and Drugs in Trials. It also hosts the ''SzGene'' database, an unbiased field synopsis of genetic association studies performed in schizophrenia, though this database is no longer updated. The Schizophrenia Forum was founded in 2005 by science editor Hakon Heimer as a project of the National Alliance for Research on Schizophrenia and Depression (now called the Brain & Behavior Research Foundation, with start-up funding from the National Institute of Mental Health and technical assistance from the Alzheimer Research Forum Alzheimer Research Forum (ARF), or Alzforum is a website which uses web technology to accelerate research into Alzheimer's disease. History The website was founded in 1996 by June Kinoshita, funded by an anonymous philanthropic fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Attention Deficit/hyperactivity Disorder
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterised by excessive amounts of inattention, hyperactivity, and impulsivity that are pervasive, impairing in multiple contexts, and otherwise age-inappropriate. ADHD symptoms arise from executive dysfunction, and emotional dysregulation is often considered a core symptom. In children, problems paying attention may result in poor school performance. ADHD is associated with other neurodevelopmental and mental disorders as well as some non-psychiatric disorders, which can cause additional impairment, especially in modern society. Although people with ADHD struggle to focus on tasks they are not particularly interested in completing, they are often able to maintain an unusually prolonged and intense level of attention for tasks they do find interesting or rewarding; this is known as hyperfocus. The precise causes of ADHD are unknown in the majority of cases. Genetic factors play an impor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autonomic Nervous System
The autonomic nervous system (ANS), formerly referred to as the vegetative nervous system, is a division of the peripheral nervous system that supplies internal organs, smooth muscle and glands. The autonomic nervous system is a control system that acts largely unconsciously and regulates bodily functions, such as the heart rate, its force of contraction, digestion, respiratory rate, pupillary response, urination, and sexual arousal. This system is the primary mechanism in control of the fight-or-flight response. The autonomic nervous system is regulated by integrated reflexes through the brainstem to the spinal cord and organs. Autonomic functions include control of respiration, cardiac regulation (the cardiac control center), vasomotor activity (the vasomotor center), and certain reflex actions such as coughing, sneezing, swallowing and vomiting. Those are then subdivided into other areas and are also linked to autonomic subsystems and the peripheral nervous system ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Promoter (genetics)
In genetics, a promoter is a sequence of DNA to which proteins bind to initiate transcription of a single RNA transcript from the DNA downstream of the promoter. The RNA transcript may encode a protein (mRNA), or can have a function in and of itself, such as tRNA or rRNA. Promoters are located near the transcription start sites of genes, upstream on the DNA (towards the 5' region of the sense strand). Promoters can be about 100–1000 base pairs long, the sequence of which is highly dependent on the gene and product of transcription, type or class of RNA polymerase recruited to the site, and species of organism. Promoters control gene expression in bacteria and eukaryotes. RNA polymerase must attach to DNA near a gene for transcription to occur. Promoter DNA sequences provide an enzyme binding site. The -10 sequence is TATAAT. -35 sequences are conserved on average, but not in most promoters. Artificial promoters with conserved -10 and -35 elements transcribe more slowly. Al ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
C-521T
In genetics, rs1800955 (also written as C-521T and -521C/T) is a single nucleotide polymorphism (SNP). It is located in the promoter region of the '' DRD4'' gene. This gene codes for the dopamine receptor D4. Due to the dopamine hypothesis of schizophrenia the SNP has been investigated for link to schizophrenia, and it may be slightly associated with this disorder. The SNP has been investigated with respect to novelty seeking, — a personality trait that may be measured with the Temperament and Character Inventory. A 2008 meta-analysis A meta-analysis is a statistical analysis that combines the results of multiple scientific studies. Meta-analyses can be performed when there are multiple scientific studies addressing the same question, with each individual study reporting m ... indicates a possible association between novelty seeking and C-521T though rather small. References Other Table 4from "The analysis of 51 genes in DSM-IV combined type attention deficit hy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Exon
An exon is any part of a gene that will form a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing. The term ''exon'' refers to both the DNA sequence within a gene and to the corresponding sequence in RNA transcripts. In RNA splicing, introns are removed and exons are covalently joined to one another as part of generating the mature RNA. Just as the entire set of genes for a species constitutes the genome, the entire set of exons constitutes the exome. History The term ''exon'' derives from the expressed region and was coined by American biochemist Walter Gilbert in 1978: "The notion of the cistron… must be replaced by that of a transcription unit containing regions which will be lost from the mature messengerwhich I suggest we call introns (for intragenic regions)alternating with regions which will be expressedexons." This definition was originally made for protein-coding transcripts that are spliced before being translate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
