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Life Extension
Life extension is the concept of extending the human lifespan, either modestly through improvements in medicine or dramatically by increasing the maximum lifespan beyond its generally-settled biological limit of around 125 years. Several researchers in the area, along with "life extensionists", " immortalists", or " longevists" (those who wish to achieve longer lives themselves), postulate that future breakthroughs in tissue rejuvenation, stem cells, regenerative medicine, molecular repair, gene therapy, pharmaceuticals, and organ replacement (such as with artificial organs or xenotransplantations) will eventually enable humans to have indefinite lifespans through complete rejuvenation to a healthy youthful condition (agerasia). The ethical ramifications, if life extension becomes a possibility, are debated by bioethicists. The sale of purported anti-aging products such as supplements and hormone replacement is a lucrative global industry. For example, the industry that ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Life Expectancy
Human life expectancy is a statistical measure of the estimate of the average remaining years of life at a given age. The most commonly used measure is ''life expectancy at birth'' (LEB, or in demographic notation ''e''0, where ''e''x denotes the average life remaining at age ''x''). This can be defined in two ways. ''Cohort'' LEB is the mean length of life of a birth Cohort (statistics), cohort (in this case, all individuals born in a given year) and can be computed only for cohorts born so long ago that all their members have died. ''Period'' LEB is the mean length of life of a hypothetical cohort assumed to be exposed, from birth through death, to the mortality rates observed at a given year. National LEB figures reported by national agencies and international organizations for human populations are estimates of ''period'' LEB. Human remains from the early Bronze Age indicate an LEB of 24. In 2019, world LEB was 73.3. A combination of high infant mortality and d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proteostasis
Proteostasis is the dynamic regulation of a balanced, functional proteome. The proteostasis network includes competing and integrated biological pathways within cells that control the biogenesis, folding, trafficking, and degradation of proteins present within and outside the cell. Loss of proteostasis is central to understanding the cause of diseases associated with excessive protein misfolding and degradation leading to loss-of-function phenotypes, as well as aggregation-associated degenerative disorders. Therapeutic restoration of proteostasis may treat or resolve these pathologies. Cellular proteostasis is key to ensuring successful development, healthy aging, resistance to environmental stresses, and to minimize homeostatic perturbations from pathogens such as viruses. Cellular mechanisms for maintaining proteostasis include regulated protein translation, chaperone assisted protein folding, and protein degradation pathways. Adjusting each of these mechanisms based on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chronic Disease
A chronic condition (also known as chronic disease or chronic illness) is a health condition or disease that is persistent or otherwise long-lasting in its effects or a disease that comes with time. The term ''chronic'' is often applied when the course of the disease lasts for more than three months. Common chronic diseases include diabetes, functional gastrointestinal disorder, eczema, arthritis, asthma, chronic obstructive pulmonary disease, autoimmune diseases, genetic disorders and some viral diseases such as hepatitis C and acquired immunodeficiency syndrome. An illness which is lifelong because it ends in death is a terminal illness. It is possible and not unexpected for an illness to change in definition from terminal to chronic as medicine progresses. Diabetes and HIV for example were once terminal yet are now considered chronic, due to the availability of insulin for diabetics and daily drug treatment for individuals with HIV, which allow these individuals to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Accident
An accident is an unintended, normally unwanted event that was not deliberately caused by humans. The term ''accident'' implies that the event may have been caused by Risk assessment, unrecognized or unaddressed risks. Many researchers, insurers and attorneys who specialize in unintentional Injury in humans, injury prefer to avoid using the term ''accident'', and focus on conditions that increase risk of severe injury or that reduce injury incidence and severity. For example, when a tree falls down during a wind storm, its fall may not have been directly caused by human error, but the tree's type, size, health, location, or improper maintenance may have contributed to the result. Most car crashes are the result of dangerous behavior and not purely ''accidents''; however, English speakers started using that word in the mid-20th century as a result of media manipulation by the US automobile industry. Accidental deaths were much less frequent before high-powered machinery began to sp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Child Mortality
Child mortality is the death of children under the age of five. The child mortality rate (also under-five mortality rate) refers to the probability of dying between birth and exactly five years of age expressed per 1,000 live births. It encompasses neonatal mortality and infant mortality (the probability of death in the first year of life). Reduction of child mortality is reflected in several of the United Nations' Sustainable Development Goals. Target 3.2 states that "by 2030, the goal is to end preventable deaths of newborns and children under 5 years of age with all countries aiming to reduce under‑5 mortality to as low as 25 per 1,000 live births." Child mortality rates have decreased in the last 40 years. Rapid progress has resulted in a significant decline in preventable child deaths since 1990 with the global under-5 mortality rate declining by over half between 1990 and 2016. While in 1990, 12.6 million children under age five died and in 2016, that number fell to 5 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Infant Mortality
Infant mortality is the death of an infant before the infant's first birthday. The occurrence of infant mortality in a population can be described by the infant mortality rate (IMR), which is the number of deaths of infants under one year of age per 1,000 live births. Similarly, the ''child mortality rate'', also known as the ''under-five mortality rate,'' compares the death rate of children up to the age of five. In 2013, the leading cause of infant mortality in the United States was birth defects. Other leading causes of infant mortality include birth asphyxia, pneumonia, neonatal infection, diarrhea, malaria, measles, malnutrition, congenital malformations, term birth complications such as abnormal presentation of the fetus, umbilical cord prolapse, or prolonged labor. One of the most common preventable causes of infant mortality is smoking during pregnancy. Lack of prenatal care, alcohol consumption during pregnancy, and drug use also cause complications that may result in in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
