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Dipeptides
A dipeptide is an organic compound derived from two amino acids. The constituent amino acids can be the same or different. When different, two isomers of the dipeptide are possible, depending on the sequence. Several dipeptides are physiologically important, and some are both physiologically and commercially significant. A well known dipeptide is aspartame, an artificial sweetener. Dipeptides are white solids. Many are far more water-soluble than the parent amino acids. For example, the dipeptide Ala-Gln has the solubility of 586 g/L more than 10x the solubility of Gln (35 g/L). Dipeptides also can exhibit different stabilities, e.g. with respect to hydrolysis. Gln does not withstand sterilization procedures, whereas this dipeptide does. Because dipeptides are prone to hydrolysis, the high solubility is exploited in infusions, i.e. to provide nutrition. Examples Commercial value About six dipeptides are of commercial interest. *Aspartame (''N''-L-α-aspartyl-L-phenylal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Xenortide
The xenortides (A-D) are a class of linear peptides isolated from the bacterium ''Xenorhabdus nematophila'',{{Cite journal, last=Lang, first=Gerhard, last2=Kalvelage, first2=Tim, last3=Peters, first3=Arne, last4=Wiese, first4=Jutta, last5=Imhoff, first5=Johannes F., date=2008-06-01, title=Linear and Cyclic Peptides from the Entomopathogenic Bacterium Xenorhabdus nematophilus, journal=Journal of Natural Products, volume=71, issue=6, pages=1074–1077, doi=10.1021/np800053n, pmid=18491867, issn=0163-3864 a symbiont of the entomopathogenic nematode ''Steinernema carpocapsae''. This class of compounds is known for their insect virulence and cytotoxicity, cytotoxic biological activities. The tryptamide containing compounds (xenortides B and D) show higher biological activity than the phenylethylamides (xenortides A and C). The most biologically active compound was found to be xenortide B with a potency of less than 1.6 μM activity against ''Trypanosoma brucei rhodesiense'' (sleeping sic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
