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Cuthbert Leslie Cope
Cuthbert Leslie Cope (1903–1975) was an English physician and endocrinologist. He graduated in 1924 BA from the University of Oxford. He studied medicine at University College Hospital Medical School. He qualified MRCS, LRCP in 1927 and MRCP in 1930. He graduated BM BCh in 1927 and DM in 1932. He held his residency appointments at University College Hospital. On his return to the UK he held appointments successively at St Thomas' Hospital, University College Hospital, and the Radcliffe Infirmary. Cope was elected FRCP in 1939. In 1940 he published his paper ''The Diagnostic Value of Pregnandiol Excretion in Pregnancy Disorders''. He became in 1942 a lieutenant-colonel in the RAMC; he served from 1944 to 1945 in France and Holland and then in the postwar-era in Norway. He was director of human problems research for the UK's National Coal Board from 1947 to 1949. He was then appointed to the Royal Postgraduate Medical School. By applying chromatography and isoto ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
City Of Westminster
The City of Westminster is a city and borough in Inner London. It is the site of the United Kingdom's Houses of Parliament and much of the British government. It occupies a large area of central Greater London, including most of the West End. Many London landmarks are within the borough, including Buckingham Palace, Westminster Abbey, Whitehall, Westminster Cathedral, 10 Downing Street, and Trafalgar Square. Westminster became a city in 1540, and historically, it was a part of the ceremonial county of Middlesex. Its southern boundary is the River Thames. To the City of Westminster's east is the City of London and to its west is the Royal Borough of Kensington and Chelsea. To its north is the London Borough of Camden. The borough is divided into a number of localities including the ancient political district of Westminster; the shopping areas around Oxford Street, Regent Street, Piccadilly and Bond Street; and the night-time entertainment district of Soho. Much ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Renal Function
Assessment of kidney function occurs in different ways, using the presence of symptoms and signs, as well as measurements using urine tests, blood tests, and medical imaging. Functions of a healthy kidney include maintaining a person's fluid balance, maintaining an acid-base balance; regulating electrolytes including sodium, potassium, and other electrolytes; clearing toxins; regulating blood pressure; and regulating hormones, such as erythropoietin; and activation of vitamin D. Introduction The functions of the kidney include maintenance of acid-base balance; regulation of fluid balance; regulation of sodium, potassium, and other electrolytes; clearance of toxins; absorption of glucose, amino acids, and other small molecules; regulation of blood pressure; production of various hormones, such as erythropoietin; and activation of vitamin D. Much of renal physiology is studied at the level of the nephron, the smallest functional unit of the kidney. Each nephron begins ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isotope
Isotopes are two or more types of atoms that have the same atomic number (number of protons in their nuclei) and position in the periodic table (and hence belong to the same chemical element), and that differ in nucleon numbers ( mass numbers) due to different numbers of neutrons in their nuclei. While all isotopes of a given element have almost the same chemical properties, they have different atomic masses and physical properties. The term isotope is formed from the Greek roots isos ( ἴσος "equal") and topos ( τόπος "place"), meaning "the same place"; thus, the meaning behind the name is that different isotopes of a single element occupy the same position on the periodic table. It was coined by Scottish doctor and writer Margaret Todd in 1913 in a suggestion to the British chemist Frederick Soddy. The number of protons within the atom's nucleus is called its atomic number and is equal to the number of electrons in the neutral (non-ionized) atom. Each atomic n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chromatography
In chemical analysis, chromatography is a laboratory technique for the separation of a mixture into its components. The mixture is dissolved in a fluid solvent (gas or liquid) called the ''mobile phase'', which carries it through a system (a column, a capillary tube, a plate, or a sheet) on which a material called the ''stationary phase'' is fixed. Because the different constituents of the mixture tend to have different affinities for the stationary phase and are retained for different lengths of time depending on their interactions with its surface sites, the constituents travel at different apparent velocities in the mobile fluid, causing them to separate. The separation is based on the differential partitioning between the mobile and the stationary phases. Subtle differences in a compound's partition coefficient result in differential retention on the stationary phase and thus affect the separation. Chromatography may be preparative or analytical. The purpose of preparat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Postgraduate Medical School
The Royal Postgraduate Medical School (RPMS) was an independent medical school, based primarily at Hammersmith Hospital in west London. In 1988, the school merged with the Institute of Obstetrics & Gynaecology, and in 1997 became part of Imperial College School of Medicine. History The medical school had its roots in the British Postgraduate Medical School, based at Hammersmith Hospital. It incorporated by Royal Charter in 1931 and opened in 1935. Its first director was Edinburgh Medical School graduate Francis Richard Fraser. It was the result of recommendations by the Athlone Report of 1921, and was a pioneer institution of postgraduate clinical teaching and research. The school had always been closely linked with the Hammersmith Hospital and the Medical Research Council, where its teaching research and clinical work were carried out. Senior academic staff of the school provided consultant services and academic leadership for Hammersmith Hospital. The RPMS has had an enormo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Coal Board
The National Coal Board (NCB) was the statutory corporation created to run the nationalised coal mining industry in the United Kingdom. Set up under the Coal Industry Nationalisation Act 1946, it took over the United Kingdom's collieries on "vesting day", 1 January 1947. In 1987, the NCB was renamed the British Coal Corporation, and its assets were subsequently privatised. Background Collieries were taken under government control during the First and Second World Wars. The Sankey Commission in 1919 gave R. H. Tawney, Sidney Webb and Sir Leo Chiozza Money the opportunity to advocate nationalisation, but it was rejected. Coal reserves were nationalised during the war in 1942 and placed under the control of the Coal Commission, but the mining industry remained in private hands. At the time, many coal companies were small, although some consolidation had taken place in the years before the war. Formation and organisation The NCB was one of a number of public corporations ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Army Medical Corps
The Royal Army Medical Corps (RAMC) is a specialist corps in the British Army which provides medical services to all Army personnel and their families, in war and in peace. The RAMC, the Royal Army Veterinary Corps, the Royal Army Dental Corps and Queen Alexandra's Royal Army Nursing Corps form the Army Medical Services. History Origins Medical services in the British armed services date from the formation of the Standing Regular Army after the Restoration of Charles II in 1660. Prior to this, from as early as the 13th century there are records of surgeons and physicians being appointed by the English army to attend in times of war; but this was the first time a career was provided for a Medical Officer (MO), both in peacetime and in war. For much of the next two hundred years, army medical provision was mostly arranged on a regimental basis, with each battalion arranging its own hospital facilities and medical supplies. An element of oversight was provided by the appoin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pre-eclampsia
Pre-eclampsia is a disorder of pregnancy characterized by the onset of high blood pressure and often a significant amount of protein in the urine. When it arises, the condition begins after 20 weeks of pregnancy. In severe cases of the disease there may be red blood cell breakdown, a low blood platelet count, impaired liver function, kidney dysfunction, swelling, shortness of breath due to fluid in the lungs, or visual disturbances. Pre-eclampsia increases the risk of undesirable outcomes for both the mother and the fetus. If left untreated, it may result in seizures at which point it is known as eclampsia. Risk factors for pre-eclampsia include obesity, prior hypertension, older age, and diabetes mellitus. It is also more frequent in a woman's first pregnancy and if she is carrying twins. The underlying mechanism involves abnormal formation of blood vessels in the placenta amongst other factors. Most cases are diagnosed before delivery. Commonly, pre-eclampsia continues i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pregnanediol
Pregnanediol, or 5β-pregnane-3α,20α-diol, is an inactive metabolic product of progesterone. A test can be done to measure the amount of pregnanediol in urine, which offers an indirect way to measure progesterone levels in the body. From the urine of pregnant women from London clinics, Guy Frederic Marrian isolated a substance that contained two hydroxyl groups and could be converted into a diacetate with acetic anhydride. However, the formula had not been clearly clarified. Almost at the same time, Adolf Butenandt at the Chemical University Laboratory in Göttingen investigated the constituents of pregnant urine and clarified the structure of the diol. The name pregnandiol, coined by Butenandt, is derived from the Latin verb praegnans (pregnant, pregnant), or the English pregnant and pregnancy. This gave rise to the name pregnane for the underlying parent hydrocarbon. In 1936, Venning and Browne demonstrated the presence of pregnanediol, specifically the glucuronide of pregnan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thyrotrophin
Thyroid-stimulating hormone (also known as thyrotropin, thyrotropic hormone, or abbreviated TSH) is a pituitary hormone that stimulates the thyroid gland to produce thyroxine (T4), and then triiodothyronine (T3) which stimulates the metabolism of almost every tissue in the body. It is a glycoprotein hormone produced by thyrotrope cells in the anterior pituitary gland, which regulates the endocrine function of the thyroid. Physiology Hormone levels TSH (with a half-life of about an hour) stimulates the thyroid gland to secrete the hormone thyroxine (T4), which has only a slight effect on metabolism. T4 is converted to triiodothyronine (T3), which is the active hormone that stimulates metabolism. About 80% of this conversion is in the liver and other organs, and 20% in the thyroid itself. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myxoedema
Myxedema is a term used synonymously with severe hypothyroidism. However, the term is also used to describe a dermatological change that can occur in hyperthyroidism and (rare) paradoxical cases of hypothyroidism. In this latter sense, myxedema refers to deposition of mucopolysaccharides in the dermis, which results in swelling of the affected area. One manifestation of myxedema occurring in the lower limb is pretibial myxedema, a hallmark of Graves disease, an autoimmune form of hyperthyroidism. Myxedema can also occur in Hashimoto thyroiditis and other long-standing forms of hypothyroidism. The word myxedema originates from , taken from ancient Greek to convey 'mucus' or 'slimy substance', and for "swelling". It can also be thought as nonpitting edema, in contrast to pitting edema. Signs and symptoms Myxedema can occur in the lower leg ( pretibial myxedema) and behind the eyes ( exophthalmos). Severe cases, requiring hospitalization can exhibit signs of hypothermia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Graves' Disease
Graves' disease (german: Morbus Basedow), also known as toxic diffuse goiter, is an autoimmune disease that affects the thyroid. It frequently results in and is the most common cause of hyperthyroidism. It also often results in an enlarged thyroid. Signs and symptoms of hyperthyroidism may include irritability, muscle weakness, sleeping problems, a fast heartbeat, poor tolerance of heat, diarrhea and unintentional weight loss. Other symptoms may include thickening of the skin on the shins, known as pretibial myxedema, and eye bulging, a condition caused by Graves' ophthalmopathy. About 25 to 30% of people with the condition develop eye problems. The exact cause of the disease is unclear; however, it is believed to involve a combination of genetic and environmental factors. A person is more likely to be affected if they have a family member with the disease. If one twin is affected, a 30% chance exists that the other twin will also have the disease. The onset of disease may ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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