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Cornea Verticillata
Cornea verticillata, also called vortex keratopathy or whorl keratopathy, is a condition characterised by corneal deposits at the level of the basal epithelium forming a faint golden-brown whorl pattern. It is seen in Fabry disease or in case of prolonged amiodarone Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of cardiac dysrhythmias. This includes ventricular tachycardia, ventricular fibrillation, and wide complex tachycardia, atrial fibrillation, and paroxys ... intake. Furthermore, it is a common adverse side effect of the use of rho-kinase inhibitors in glaucoma therapy. __TOC__ Presentation No ocular complaints or visual difficulty is usually present. Pathophysiology This keratopathy is probably a type of drug-induced lipidosis. Diagnosis References {{reflist Medical signs Disorders of sclera and cornea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Corneal Deposits
The cornea is the transparent front part of the eyeball which covers the iris, pupil, and anterior chamber. Along with the anterior chamber and lens, the cornea refracts light, accounting for approximately two-thirds of the eye's total optical power. In humans, the refractive power of the cornea is approximately 43 dioptres. The cornea can be reshaped by surgical procedures such as LASIK. While the cornea contributes most of the eye's focusing power, its focus is fixed. Accommodation (the refocusing of light to better view near objects) is accomplished by changing the geometry of the lens. Medical terms related to the cornea often start with the prefix "'' kerat-''" from the Greek word κέρας, ''horn''. Structure The cornea has unmyelinated nerve endings sensitive to touch, temperature and chemicals; a touch of the cornea causes an involuntary reflex to close the eyelid. Because transparency is of prime importance, the healthy cornea does not have or need blood vessels ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Basal Epithelium
Basal or basilar is a term meaning ''base'', ''bottom'', or ''minimum''. Science * Basal (anatomy), an anatomical term of location for features associated with the base of an organism or structure * Basal (medicine), a minimal level that is necessary for health or life, such as a minimum insulin dose * Basal (phylogenetics), a relative position in a phylogenetic tree closer to the root Places * Basal, Hungary, a village in Hungary * Basal, Pakistan, a village in the Attock District Other * Basal plate (other) * Basal sliding, the act of a glacier sliding over the bed before it due to meltwater increasing the water pressure underneath the glacier causing it to be lifted from its bed * Basal conglomerate, see conglomerate (geology) Conglomerate () is a sedimentary rock made up of rounded gravel-sized pieces of rock surrounded by finer-grained sediments (such as sand, silt, or clay). The larger fragments within conglomerate are called clasts, while the finer sediment ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fabry Disease
Fabry disease, also known as Anderson–Fabry disease, is a rare genetic disease that can affect many parts of the body, including the kidneys, heart, brain, and skin. Fabry disease is one of a group of conditions known as lysosomal storage diseases. The genetic mutation that causes Fabry disease interferes with the function of an enzyme that processes biomolecules known as sphingolipids, leading to these substances building up in the walls of blood vessels and other organs. It is inherited in an X-linked manner. Fabry disease is sometimes diagnosed using a blood test that measures the activity of the affected enzyme called alpha-galactosidase, but genetic testing is also sometimes used, particularly in females. The treatment for Fabry disease varies depending on the organs affected by the condition, and the underlying cause can be addressed by replacing the enzyme that is lacking. The first descriptions of the condition were made simultaneously by dermatologist Johannes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amiodarone
Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of cardiac dysrhythmias. This includes ventricular tachycardia, ventricular fibrillation, and wide complex tachycardia, atrial fibrillation, and paroxysmal supraventricular tachycardia. Evidence in cardiac arrest, however, is poor. It can be given by mouth, intravenously, or intraosseously. When used by mouth, it can take a few weeks for effects to begin. Common side effects include feeling tired, tremor, nausea, and constipation. As amiodarone can have serious side effects, it is mainly recommended only for significant ventricular arrhythmias. Serious side effects include lung toxicity such as interstitial pneumonitis, liver problems, heart arrhythmias, vision problems, thyroid problems, and death. If taken during pregnancy or breastfeeding it can cause problems in the fetus or the infant. It is a class III antiarrhythmic medication. It works partly by increasing the time before a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rho Kinase Inhibitor
Rho-kinase inhibitors (rho-associated protein kinase inhibitor or ROCK inhibitor) are a series of compounds that target rho kinase (ROCK) and inhibit the ROCK pathway. Clinical trials have found that inhibition of the ROCK pathway contributes to the cardiovascular benefits of statin therapy. Furthermore, ROCK inhibitors may have clinical applications for anti-erectile dysfunction, Antihypertensive drug, antihypertension, and tumor metastasis inhibition. More recently they have been studied for the treatment of glaucoma and as a therapeutic target for the treatment of cardiovascular diseases, including ischemic stroke. While statin therapy has been demonstrated to reduce the risk of major cardiovascular events, including ischemic stroke, the interplay between the ROCK pathway and statin therapy to treat and prevent strokes in older adults has not yet been proven. On a cellular level, Rho-associated protein kinase, ROCK has multiple functions, including regulation of smooth muscle cell ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glaucoma Medication
Glaucoma medication is divided into groups based on chemical structure and pharmacologic action. The goal of currently available glaucoma therapy is to preserve visual function by lowering intraocular pressure (IOP) in patients that have an increased intraocular pressure. Medical uses Agents in common clinical use include: * Prostaglandin analogs * Parasympathomimetic (miotic) agents, including cholinergic and anticholinesterase agents * Carbonic anhydrase inhibitors (oral and topical) * Adrenergic antagonists (nonselective and selective Beta1-antagonists) * Alpha 2 agonists * Hyperosmotic agents * Nitric oxide donators * Rho kinase inhibitors When comparing people with primary open-angle glaucoma and ocular hypertension, medical intraocular pressure lowering treatment slowed down the progression of visual field loss. Comparison table Combinations Fotil is a combination drug consisting of:FASS (drug formulary)Fotil Retrieved 2015-02-17 *Pilocarpine, a parasympathomime ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Signs
Signs and symptoms are diagnostic indications of an illness, injury, or condition. Signs are objective and externally observable; symptoms are a person's reported subjective experiences. A sign for example may be a higher or lower temperature than normal, raised or lowered blood pressure or an abnormality showing on a medical scan. A symptom is something out of the ordinary that is experienced by an individual such as feeling feverish, a headache or other pains in the body, which occur as the body's immune system fights off an infection. Signs and symptoms Signs A medical sign is an objective observable indication of a disease, injury, or medical condition that may be detected during a physical examination. These signs may be visible, such as a rash or bruise, or otherwise detectable such as by using a stethoscope or taking blood pressure. Medical signs, along with symptoms, help in forming a diagnosis. Some examples of signs are nail clubbing of either the fingernails or t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
