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Conjoined Twins
Conjoined twins, popularly referred to as Siamese twins, are twins joined '' in utero''. It is a very rare phenomenon, estimated to occur in anywhere between one in 50,000 births to one in 200,000 births, with a somewhat higher incidence in southwest Asia and Africa. Approximately half are stillborn, and an additional one-third die within 24 hours. Most live births are female, with a ratio of 3:1. Two possible explanations of the cause of conjoined twins have been proposed. The one that is generally accepted is ''fission'', in which the fertilized egg splits partially. The other explanation, no longer believed to be accurate, is ''fusion'', in which the fertilized egg completely separates, but stem cells (that search for similar cells) find similar stem cells on the other twin and fuse the twins together. Conjoined twins and some monozygotic, but not conjoined, twins share a single common chorion, placenta, and amniotic sac '' in utero''. Chang and Eng Bunker (1811–1874) we ...
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Ischiopagi
Ischiopagi comes from the Greek word ''ischio-'' meaning hip (ilium) and ''-pagus'' meaning fixed or united. It is the medical term used for conjoined twins (Class V) who are united at the pelvis. The twins are classically joined with the vertebral Axis (anatomy), axis at 180°. The conjoined twins usually have four arms; two, three or four legs; and typically one external genitalia and anus. It is mostly confused with pygopagus where the twins are joined dorsally at the buttocks facing away from each other, whereas ischiopagus twins are joined ventrally and caudally at the sacrum and coccyx. Parapagus is also similar to ischiopagus; however, parapagus twins are joined side-by-side whereas ischiopagus twins typically have spines connected at a 180° angle, facing away from one another. Classification ;Ischiopagus dipus: This is the rarest variety with the twins sharing two legs with no lower extremities on one side. ;Ischiopagus tripus: These twins share three legs, the third leg ...
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Twin
Twins are two offspring produced by the same pregnancy.MedicineNet > Definition of Twin Last Editorial Review: 19 June 2000 Twins can be either ''monozygotic'' ('identical'), meaning that they develop from one zygote, which splits and forms two embryos, or ''dizygotic'' ('non-identical' or 'fraternal'), meaning that each twin develops from a separate egg and each egg is fertilized by its own sperm cell. Since identical twins develop from one zygote, they will share the same sex, while fraternal twins may or may not. In very rare cases, fraternal or (semi-) identical twins can have the same mother and different fathers ( heteropaternal superfecundation). In contrast, a fetus that develops alone in the womb (the much more common case in humans) is called a ''singleton'', and the general term for one offspring of a multiple birth is a ''multiple''. Unrelated look-alikes whose resemblance parallels that of twins are referred to as doppelgänger. Statistics The human twin birth ...
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BMP4
Bone morphogenetic protein 4 is a protein that in humans is encoded by ''BMP4'' gene. BMP4 is found on chromosome 14q22-q23. BMP4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The Protein family, superfamily includes large families of growth and differentiation factors. BMP4 is highly conserved evolutionarily. BMP4 is found in early embryonic development in the ventral marginal zone and in the eye, heart blood and otic vesicle. Discovery Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Function BMP4 is a polypeptide belonging to the Transforming growth factor beta, TGF-β superfamily of proteins. It, like other bone morphogenetic proteins, is involved in bone and cartilage development, specifically tooth and limb development and fracture repair. This particular family member plays an i ...
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Human Anus
In humans, the anus (: anuses or ani; from Latin ''ānus'', "ring", "circle") is the external opening of the rectum located inside the intergluteal cleft. Two sphincters control the exit of Human feces, feces from the body during an act of defecation, which is the primary function of the anus. These are the internal anal sphincter and the external anal sphincter, which are circular muscles that normally maintain constriction of the orifice and which relax as required by normal physiological functioning. The inner sphincter is involuntary and the outer is voluntary. Above the anus is the perineum, which is also located beneath the vulva or scrotum. In part owing to its exposure to feces, a number of medical conditions may affect the anus, such as hemorrhoids. The anus is the site of potential infections and other conditions, including cancer (see anal cancer). With anal sex, the anus can play a role in Human sexuality, sexuality. Attitudes toward anal sex vary, and it is illeg ...
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Genitalia
A sex organ, also known as a reproductive organ, is a part of an organism that is involved in sexual reproduction. Sex organs constitute the primary sex characteristics of an organism. Sex organs are responsible for producing and transporting gametes, as well as facilitating fertilization and supporting the development and birth of offspring. Sex organs are found in many species of animals and plants, with their features varying depending on the species. Sex organs are typically differentiated into male and female types. In animals (including humans), the male sex organs include the testicles, epididymides, and penis; the female sex organs include the clitoris, ovaries, oviducts, and vagina. The testicle in the male and the ovary in the female are called the ''primary sex organs''. All other sex-related organs are known as ''secondary sex organs''. The outer parts are known as the genitals or external genitalia, visible at birth in both sexes, while the inner parts are refe ...
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Vertebral Column
The spinal column, also known as the vertebral column, spine or backbone, is the core part of the axial skeleton in vertebrates. The vertebral column is the defining and eponymous characteristic of the vertebrate. The spinal column is a segmented column of vertebrae that surrounds and protects the spinal cord. The vertebrae are separated by intervertebral discs in a series of cartilaginous joints. The dorsal portion of the spinal column houses the spinal canal, an elongated body cavity, cavity formed by the alignment of the vertebral neural arches that encloses and protects the spinal cord, with spinal nerves exiting via the intervertebral foramina to innervate each body segment. There are around 50,000 species of animals that have a vertebral column. The human spine is one of the most-studied examples, as the general structure of human vertebrae is fairly homology (biology), typical of that found in other mammals, reptiles, and birds. The shape of the vertebral body does, howev ...
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Xiphoid Process
The xiphoid process (), also referred to as the ensiform process, xiphisternum, or metasternum, constitutes a small cartilaginous process (extension) located in the inferior segment of the sternum, typically ossified in adult humans. Both the Greek-derived term ''xiphoid'' and its Latin equivalent, ''ensiform'', connote a "swordlike" or "sword-shaped" morphology. Structure The xiphoid process is anatomically situated at the level of the 9th thoracic vertebra (T9) and corresponds to the T7 dermatome. Development In neonates and young infants, particularly smaller infants, the tip of the xiphoid process may be seen as a palpable lump situated just below the sternal notch. Between the ages of 15 and 29, the xiphoid process typically undergoes fusion with the body of the sternum through a fibrous joint. Unlike the synovial articulation of major joints, this joint does not permit movement. Ossification of the xiphoid process typically occurs around the age of 40. Variation The xip ...
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Janus (mythology)
In ancient Roman religion and myth, Janus ( ; ) is the god of beginnings, gates, transitions, time, duality, doorways, passages, frames, and endings. He is usually depicted as having two faces. The month of January is named for Janus (''Ianuarius''). According to ancient Roman farmers' almanacs, Juno was mistaken as the tutelary deity of the month of January, but Juno is the tutelary deity of the month of June. Janus presided over the beginning and ending of conflict, and hence war and peace. The gates of the Temple of Janus in Rome were opened in time of war and closed to mark the arrival of peace. As a god of transitions, he had functions pertaining to birth and to journeys and exchange, and in his association with Portunus, a similar harbor and gateway god, he was concerned with travelling, trading, and shipping. Janus had no flamen or specialised priest ''( sacerdos)'' assigned to him, but the King of the Sacred Rites ''(rex sacrorum)'' himself carried out his ceremon ...
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Human Skull
The skull, or cranium, is typically a bony enclosure around the brain of a vertebrate. In some fish, and amphibians, the skull is of cartilage. The skull is at the head end of the vertebrate. In the human, the skull comprises two prominent parts: the neurocranium and the facial skeleton, which evolved from the first pharyngeal arch. The skull forms the frontmost portion of the axial skeleton and is a product of cephalization and vesicular enlargement of the brain, with several special senses structures such as the eyes, ears, nose, tongue and, in fish, specialized tactile organs such as barbels near the mouth. The skull is composed of three types of bone: cranial bones, facial bones and ossicles, which is made up of a number of fused flat and irregular bones. The cranial bones are joined at firm fibrous junctions called sutures and contains many foramina, fossae, processes, and sinuses. In zoology, the openings in the skull are called fenestrae, the ...
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Craniopagus Twins
Craniopagus twins are conjoined twins who are fused at the cranium. The union may occur on any portion of the cranium, but does not primarily involve either the face or the foramen magnum; the two brains are usually separate, but they may share some brain tissue. Conjoined twins are genetically identical and always share the same sex. The thorax and abdomen are separate and each twin has their own umbilicus and umbilical cord. The condition is extremely rare, with an incidence of approximately 1 in 2.5 million live births. An estimated 50 craniopagus twins are born around the world every year , with only 15 twins surviving beyond the first 30 days of life. Relatively few craniopagus twins survive the perinatal period; approximately 40% of conjoined twins are stillborn and an additional 33% die within the immediate perinatal period, usually from organ abnormalities and failure. However, 25% of craniopagus twins survive and may be considered for a surgical separation; several ...
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Parasitic Twin
A parasitic twin, also known as an asymmetrical twin or unequal conjoined twin, occurs when a twin embryo begins developing in utero, but the pair does not fully separate, and one embryo maintains dominant development at the expense of the other. It results from the same processes that also produces '' vanishing twins'' and ''conjoined twins'', and may represent a continuum between the two. In parasitic twins, one ceases development during gestation and is vestigial to a mostly fully formed, otherwise healthy individual twin. The undeveloped twin is termed as '' parasitic'', because it is incompletely formed or wholly dependent on the body functions of the complete fetus. The independent twin is called the autosite. The autosite, together with the parasite, are collectively referred to as heteropagus twins. Variants TRAP sequence The twin reversed arterial perfusion, or TRAP sequence, results in an 'acardiac twin', a parasitic twin that fails to develop a head, arms and a heart ...
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Diaphragm (anatomy)
The thoracic diaphragm, or simply the diaphragm (; ), is a sheet of internal skeletal muscle in humans and other mammals that extends across the bottom of the thoracic cavity. The diaphragm is the most important muscle of respiration, and separates the thoracic cavity, containing the heart and lungs, from the abdominal cavity: as the diaphragm contracts, the volume of the thoracic cavity increases, creating a negative pressure there, which draws air into the lungs. Its high oxygen consumption is noted by the many mitochondria and capillaries present; more than in any other skeletal muscle. The term ''diaphragm'' in anatomy, created by Gerard of Cremona, can refer to other flat structures such as the urogenital diaphragm or Pelvic floor, pelvic diaphragm, but "the diaphragm" generally refers to the thoracic diaphragm. In humans, the diaphragm is slightly asymmetric—its right half is higher up (superior) to the left half, since the large liver rests beneath the right half of t ...
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