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Bayesian Model Of Computational Anatomy
Computational anatomy (CA) is a discipline within medical imaging focusing on the study of anatomical shape and form at the visible or Gross anatomy, gross anatomical scale of morphology (biology), morphology. The field is broadly defined and includes foundations in anatomy, applied mathematics and pure mathematics, including medical imaging, neuroscience, physics, probability, and statistics. It focuses on the anatomical structures being imaged, rather than the medical imaging devices. The central focus of the sub-field of computational anatomy within medical imaging is mapping information across anatomical coordinate systems most often dense information measured within a magnetic resonance imaging, magnetic resonance image (MRI). The introduction of flows into CA, which are akin to the equations of motion used in fluid dynamics, exploit the notion that dense coordinates in image analysis follow the Lagrangian and Eulerian specification of the flow field, Lagrangian and Euleri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Imaging
Medical imaging is the technique and process of imaging the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues (physiology). Medical imaging seeks to reveal internal structures hidden by the skin and bones, as well as to diagnose and treat disease. Medical imaging also establishes a database of normal anatomy and physiology to make it possible to identify abnormalities. Although imaging of removed organ (anatomy), organs and Tissue (biology), tissues can be performed for medical reasons, such procedures are usually considered part of pathology instead of medical imaging. Measurement and recording techniques that are not primarily designed to produce images, such as electroencephalography (EEG), magnetoencephalography (MEG), electrocardiography (ECG), and others, represent other technologies that produce data susceptible to representation as a parameter graph versus time or maps that contain ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurodevelopmental
The development of the nervous system, or neural development (neurodevelopment), refers to the processes that generate, shape, and reshape the nervous system of animals, from the earliest stages of embryonic development to adulthood. The field of neural development draws on both neuroscience and developmental biology to describe and provide insight into the cellular and molecular mechanisms by which complex nervous systems develop, from nematodes and fruit flies to mammals. Defects in neural development can lead to malformations such as holoprosencephaly, and a wide variety of neurological disorders including limb paresis and paralysis, balance and vision disorders, and seizures, and in humans other disorders such as Rett syndrome, Down syndrome and intellectual disability. Vertebrate brain development The vertebrate central nervous system (CNS) is derived from the ectoderm—the outermost germ layer of the embryo. A part of the dorsal ectoderm becomes specified ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurodegenerative
A neurodegenerative disease is caused by the progressive loss of neurons, in the process known as neurodegeneration. Neuronal damage may also ultimately result in their death. Neurodegenerative diseases include amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Alzheimer's disease, Huntington's disease, multiple system atrophy, tauopathies, and prion diseases. Neurodegeneration can be found in the brain at many different levels of neuronal circuitry, ranging from molecular to systemic. Because there is no known way to reverse the progressive degeneration of neurons, these diseases are considered to be incurable; however research has shown that the two major contributing factors to neurodegeneration are oxidative stress and inflammation. Biomedical research has revealed many similarities between these diseases at the subcellular level, including atypical protein assemblies (like proteinopathy) and induced cell death. These similarities suggest that therapeut ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Statistical Theory
The theory of statistics provides a basis for the whole range of techniques, in both study design and data analysis, that are used within applications of statistics. The theory covers approaches to statistical-decision problems and to statistical inference, and the actions and deductions that satisfy the basic principles stated for these different approaches. Within a given approach, statistical theory gives ways of comparing statistical procedures; it can find the best possible procedure within a given context for given statistical problems, or can provide guidance on the choice between alternative procedures. Apart from philosophical considerations about how to make statistical inferences and decisions, much of statistical theory consists of mathematical statistics, and is closely linked to probability theory, to utility theory, and to optimization. Scope Statistical theory provides an underlying rationale and provides a consistent basis for the choice of methodology used i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maximum A Posteriori Estimation
An estimation procedure that is often claimed to be part of Bayesian statistics is the maximum a posteriori (MAP) estimate of an unknown quantity, that equals the mode of the posterior density with respect to some reference measure, typically the Lebesgue measure. The MAP can be used to obtain a point estimate of an unobserved quantity on the basis of empirical data. It is closely related to the method of maximum likelihood (ML) estimation, but employs an augmented optimization objective which incorporates a prior density over the quantity one wants to estimate. MAP estimation is therefore a regularization of maximum likelihood estimation, so is not a well-defined statistic of the Bayesian posterior distribution. Description Assume that we want to estimate an unobserved population parameter \theta on the basis of observations x. Let f be the sampling distribution of x, so that f(x\mid\theta) is the probability of x when the underlying population parameter is \theta. Then t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synthesized Cortical Structures From Common Template
Synthesis or synthesize may refer to: Science Chemistry and biochemistry *Chemical synthesis, the execution of chemical reactions to form a more complex molecule from chemical precursors **Organic synthesis, the chemical synthesis of organic compounds ***Total synthesis, the complete organic synthesis of complex organic compounds, usually without the aid of biological processes ***Convergent synthesis or linear synthesis, a strategy to improve the efficiency of multi-step chemical syntheses **Dehydration synthesis, a chemical synthesis resulting in the loss of a water molecule *Biosynthesis, the creation of an organic compound in a living organism, usually aided by enzymes **Photosynthesis, a biochemical reaction using a carbon molecule to produce an organic molecule, using sunlight as a catalyst **Chemosynthesis, the synthesis of biological compounds into organic waste, using methane or an oxidized molecule as a catalyst **Amino acid synthesis, the synthesis of an amino acid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Metric Space Of Shapes And Forms
''The'' is a grammatical article in English, denoting nouns that are already or about to be mentioned, under discussion, implied or otherwise presumed familiar to listeners, readers, or speakers. It is the definite article in English. ''The'' is the most frequently used word in the English language; studies and analyses of texts have found it to account for seven percent of all printed English-language words. It is derived from gendered articles in Old English which combined in Middle English and now has a single form used with nouns of any gender. The word can be used with both singular and plural nouns, and with a noun that starts with any letter. This is different from many other languages, which have different forms of the definite article for different genders or numbers. Pronunciation In most dialects, "the" is pronounced as (with the voiced dental fricative followed by a schwa) when followed by a consonant sound, and as (homophone of the archaic pronoun ''thee'') ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Computational Anatomy
Computational anatomy is an interdisciplinary field of biology focused on quantitative investigation and modelling of anatomical shapes variability. It involves the development and application of mathematical, statistical and data-analytical methods for modelling and simulation of biological structures. The field is broadly defined and includes foundations in anatomy, applied mathematics and pure mathematics, machine learning, computational mechanics, computational science, biological imaging, neuroscience, physics, probability, and statistics; it also has strong connections with fluid mechanics and geometric mechanics. Additionally, it complements newer, interdisciplinary fields like bioinformatics and neuroinformatics in the sense that its interpretation uses metadata derived from the original sensor imaging modalities (of which magnetic resonance imaging is one example). It focuses on the anatomical structures being imaged, rather than the medical imaging devices. It is similar i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sobolev Space
In mathematics, a Sobolev space is a vector space of functions equipped with a norm that is a combination of ''Lp''-norms of the function together with its derivatives up to a given order. The derivatives are understood in a suitable weak sense to make the space complete, i.e. a Banach space. Intuitively, a Sobolev space is a space of functions possessing sufficiently many derivatives for some application domain, such as partial differential equations, and equipped with a norm that measures both the size and regularity of a function. Sobolev spaces are named after the Russian mathematician Sergei Sobolev. Their importance comes from the fact that weak solutions of some important partial differential equations exist in appropriate Sobolev spaces, even when there are no strong solutions in spaces of continuous functions with the derivatives understood in the classical sense. Motivation In this section and throughout the article \Omega is an open subset of \R^n. There are man ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hilbert Space
In mathematics, a Hilbert space is a real number, real or complex number, complex inner product space that is also a complete metric space with respect to the metric induced by the inner product. It generalizes the notion of Euclidean space. The inner product allows lengths and angles to be defined. Furthermore, Complete metric space, completeness means that there are enough limit (mathematics), limits in the space to allow the techniques of calculus to be used. A Hilbert space is a special case of a Banach space. Hilbert spaces were studied beginning in the first decade of the 20th century by David Hilbert, Erhard Schmidt, and Frigyes Riesz. They are indispensable tools in the theories of partial differential equations, mathematical formulation of quantum mechanics, quantum mechanics, Fourier analysis (which includes applications to signal processing and heat transfer), and ergodic theory (which forms the mathematical underpinning of thermodynamics). John von Neumann coined the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lagrangian Flow
Lagrangian may refer to: Mathematics * Lagrangian function, used to solve constrained minimization problems in optimization theory; see Lagrange multiplier ** Lagrangian relaxation, the method of approximating a difficult constrained problem with an easier problem having an enlarged feasible set ** Lagrangian dual problem, the problem of maximizing the value of the Lagrangian function, in terms of the Lagrange-multiplier variable; See Dual problem * Lagrangian, a functional whose extrema are to be determined in the calculus of variations * Lagrangian submanifold, a class of submanifolds in symplectic geometry * Lagrangian system, a pair consisting of a smooth fiber bundle and a Lagrangian density Physics * Lagrangian mechanics, a formulation of classical mechanics * Lagrangian (field theory), a formalism in classical field theory * Lagrangian point, a position in an orbital configuration of two large bodies * Lagrangian coordinates, a way of describing the motions of particles of a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
