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Anabolic-androgenic Steroids Abuse
Research data indicates that steroids affect the serotonin and dopamine neurotransmitter systems of the brain. In an animal study, male rats developed a conditioned place preference to testosterone injections into the nucleus accumbens, an effect blocked by dopamine antagonists, which suggests that androgen reinforcement is mediated by the brain. Moreover, testosterone appears to act through the Mesolimbic pathway, mesolimbic dopamine system, a common substrate for addictive substances. Nonetheless, androgen reinforcement is not comparable to that of cocaine, nicotine, or heroin. Instead, testosterone resembles other mild reinforcers, such as caffeine, or benzodiazepines. The potential for androgen addiction remains to be determined. Anabolic steroids are not psychoactive and cannot be detected by stimuli devices like a pupilometer which makes them hard to spot as a source of neuropsychological imbalances in some AAS users. Dependence potential The Diagnostic and Statistical Manual ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rational Harm Assessment Of Drugs Radar Plot
Rationality is the quality of being guided by or based on reasons. In this regard, a person acts rationally if they have a good reason for what they do or a belief is rational if it is based on strong evidence. This quality can apply to an ability, as in rational animal, to a psychological process, like reasoning, to mental states, such as beliefs and intentions, or to persons who possess these other forms of rationality. A thing that lacks rationality is either ''arational'', if it is outside the domain of rational evaluation, or ''irrational'', if it belongs to this domain but does not fulfill its standards. There are many discussions about the essential features shared by all forms of rationality. According to reason-responsiveness accounts, to be rational is to be responsive to reasons. For example, dark clouds are a reason for taking an umbrella, which is why it is rational for an agent to do so in response. An important rival to this approach are coherence-based accounts ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Body Dysmorphic Disorder
Body dysmorphic disorder (BDD), occasionally still called dysmorphophobia, is a mental disorder characterized by the obsessive idea that some aspect of one's own body part or appearance is severely flawed and therefore warrants exceptional measures to hide or fix it. In BDD's delusional variant, the flaw is imagined. If the flaw is actual, its importance is severely exaggerated. Either way, thoughts about it are pervasive and intrusive, and may occupy several hours a day, causing severe distress and impairing one's otherwise normal activities. BDD is classified as a somatoform disorder A somatic symptom disorder, formerly known as a somatoform disorder,(2013) DSM-5 [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Testicular Atrophy
Testicular atrophy is a medical condition in which one or both testicles (or "testes") diminish in size and may be accompanied by reduced testicular function. Testicular atrophy is not related to the temporary shrinkage of the surrounding scrotum, which might occur in response to cold temperature. As the testicles are involved in testosterone and sperm production, the signs and symptoms of testicular atrophy overlap with those related to infertility or low testosterone levels. In a prepubescent person with testicular atrophy, there may be underdevelopment of secondary sex characteristics (e.g. lack of penis growth). In sexually developed individuals, testicular atrophy may be accompanied with lower sex drive and increased breast tissue. Additional signs and symptoms vary and can depend on the specific cause of the testicle shrinkage. Some causes include age, alcohol use, hormone therapy, direct damage to the testicles, and infection. Diagnosis of testicular atrophy includes physica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gynecomastia
Gynecomastia (also spelled gynaecomastia) is the abnormal non-cancerous enlargement of one or both breasts in males due to the growth of breast tissue as a result of a hormone imbalance between estrogens and androgens. Updated by Brent Wisse (10 November 2018) Gynecomastia can cause significant psychological distress or unease. Gynecomastia can be normal in newborn babies due to exposure to estrogen from the mother, in adolescents going through puberty, in older men over age 50, and/or in obese men. Most occurrences of gynecomastia do not require diagnostic tests. Gynecomastia may be caused by abnormal hormone changes, any condition that leads to an increase in the ratio of estrogens/androgens such as liver disease, kidney failure, thyroid disease and some non-breast tumors. Alcohol and some drugs can also cause breast enlargement. Other causes may include Klinefelter syndrome, metabolic dysfunction, or a natural decline in testosterone production. This may occur even if ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vince McMahon
Vincent Kennedy McMahon (; born August 24, 1945) is an American media proprietor and retired professional wrestling promoter, executive, and performer. From 1982 to 2022, he served as the chairman and chief executive officer (CEO) of WWE, the world's largest professional wrestling company, of which he is still majority owner and wields the majority of voting power. He is also the founder and owner of Alpha Entertainment. Born in Pinehurst, North Carolina, McMahon graduated from East Carolina University with a degree in business in 1968 and began his tenure in professional wrestling as a commentator for the then-World Wide Wrestling Federation (WWWF) for most of the 1970s; McMahon bought the company from his father, Vincent J. McMahon, in 1982 and almost monopolized the industry, which previously operated as separate entities across the United States. This led to the development of the annual WrestleMania, which became one of the most successful professional wrestling event ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Linda McMahon
Linda Marie McMahon (née Edwards; October 4, 1948) is an American political executive, retired professional wrestler, executive, and performer. She served as the 25th administrator of the Small Business Administration from 2017 to 2019. McMahon, along with her husband, Vince McMahon, founded sports entertainment company Titan Sports, Inc. (today WWE) where she worked as the president and later CEO from 1980 to 2009. During this time, the company grew from a small regional business in the northeast to a large multinational corporation. Among other things, she initiated the company's civic programs, ''Get REAL'' and ''Smackdown Your Vote''. She gave occasional on-screen performances, most notably in a feud with her husband that culminated at WrestleMania X-Seven. In 2009, McMahon left the WWE to run for a seat in the United States Senate from Connecticut as a Republican, but lost to Democrat Richard Blumenthal in the 2010 general election. She was the Republican nominee for Co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Total Nonstop Action Wrestling
Impact Wrestling (stylized as ''IMPACT! Wrestling''), is an American professional wrestling promotion based in Nashville, Tennessee. It is a subsidiary of Anthem Sports & Entertainment. Founded by Jeff and Jerry Jarrett in 2002, the promotion was initially known as NWA: Total Nonstop Action (''NWA-TNA'') and was associated with the National Wrestling Alliance (NWA), though not an official member. In 2004, the promotion became known as Total Nonstop Action Wrestling (TNA), but it continued to use the NWA World Heavyweight and Tag Team championships as part of its agreement with the NWA. After the agreement ended in 2007, the company created its own TNA World Heavyweight and TNA World Tag Team championships. The promotion was purchased by Anthem at the beginning of 2017 and, in March of that year, was fully rebranded under its current name after its flagship, weekly television series. From its inception, the promotion had been considered the second-largest in the United ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States House Committee On Oversight And Government Reform
The Committee on Oversight and Reform is the main investigative committee of the United States House of Representatives. The committee's broad jurisdiction and legislative authority make it one of the most influential and powerful panels in the House. Its chairman is one of only three in the House with the authority to issue subpoenas without a committee vote or consultation with the ranking member. However, in recent history, it has become practice to refrain from unilateral subpoenas. Carolyn Maloney ( D-New York) served as acting chair of the committee following the death of Elijah Cummings ( D-Maryland) on October 17, 2019; she was elected chair a month later. Representative Jim Jordan served as ranking member from January 3, 2019, until March 12, 2020. On March 31, 2020, Jordan started his second stint as ranking member. Representative Mark Meadows served as ranking member from March 13, 2020, until March 30, 2020, when he resigned his congressional seat to become White ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Police Corruption
Police corruption is a form of police misconduct in which law enforcement officers end up breaking their political contract and abuse their power for personal gain. This type of corruption may involve one or a group of officers. Internal police corruption is a challenge to public trust, cohesion of departmental policies, human rights and legal violations involving serious consequences. Police corruption can take many forms, such as bribery. Types Soliciting or accepting bribes in exchange for not reporting organized drug or prostitution rings or other illegal activities and violations of law, county and city ordinances and state and federal laws. Bribes may also include leasing unlawful access to proprietary law enforcement databases and systems. Flouting the police code of conduct in order to secure convictions of civilians and suspects—for example, through the use of falsified evidence. There are also situations where law enforcement officers may deliberately and sy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Abuse Of Power
Abuse is the improper usage or treatment of a thing, often to unfairly or improperly gain benefit. Abuse can come in many forms, such as: physical or verbal maltreatment, injury, assault, violation, rape, unjust practices, crimes, or other types of aggression. To these descriptions, one can also add the Kantian notion of the wrongness of using another human being as means to an end rather than as ends in themselves. Some sources describe abuse as "socially constructed", which means there may be more or less recognition of the suffering of a victim at different times and societies. Types and contexts of abuse Abuse of authority Abuse of authority includes harassment, interference, pressure, and inappropriate requests or favors. Abuse of corpse :''See: Necrophilia'' Necrophilia involves possessing a physical attraction to dead bodies that may led to acting upon sexual urges. As corpses are dead and cannot give consent, any manipulation, removal of parts, mutilation, or se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Enforcement Administration
The Drug Enforcement Administration (DEA; ) is a United States federal law enforcement agency under the U.S. Department of Justice tasked with combating drug trafficking and distribution within the U.S. It is the lead agency for domestic enforcement of the Controlled Substances Act, sharing concurrent jurisdiction with the Federal Bureau of Investigation, the U.S. Immigration and Customs Enforcement, and U.S. Customs and Border Protection although the DEA has sole responsibility for coordinating and pursuing U.S. drug investigations both domestically and abroad. The DEA has an intelligence unit that is also a member of the U.S. Intelligence Community. While the unit is part of the DEA chain-of-command, it also reports to the Director of National Intelligence. History and mandate The Drug Enforcement Administration was established on July 1, 1973, by Reorganization Plan No. 2 of 1973, signed by President Richard Nixon on July 28. It proposed the creation of a singl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Exposure Therapy
Exposure therapy is a technique in behavior therapy to treat anxiety disorders. Exposure therapy involves exposing the target patient to the anxiety source or its context without the intention to cause any danger (desensitization). Doing so is thought to help them overcome their anxiety or distress. Procedurally, it is similar to the fear extinction paradigm developed for studying laboratory rodents. Numerous studies have demonstrated its effectiveness in the treatment of disorders such as generalized anxiety disorder, social anxiety disorder, obsessive-compulsive disorder, post-traumatic stress disorder (PTSD), and specific phobias. Medical uses Generalized anxiety disorder There is empirical evidence that exposure therapy can be an effective treatment for people with generalized anxiety disorder, citing specifically in vivo exposure therapy, (exposure through a real life situation), which has greater effectiveness than imaginal exposure in regards to generalized anxiety dis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
