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Amyloid Plaque
Amyloid plaques (also known as neuritic plaques, amyloid beta plaques or senile plaques) are extracellular deposits of amyloid beta (Aβ) protein that present mainly in the grey matter of the brain. Degenerative neuronal elements and an abundance of microglia and astrocytes can be associated with amyloid plaques. Some plaques occur in the brain as a result of aging, but large numbers of plaques and neurofibrillary tangles are characteristic features of Alzheimer's disease. The plaques are highly variable in shape and size; in tissue sections immunostained for Aβ, they comprise a log-normal size distribution curve, with an average plaque area of 400–450 square micrometers (μm2). The smallest plaques (less than 200 μm2), which often consist of diffuse deposits of Aβ, are particularly numerous. Plaques form when Aβ misfolds and aggregates into oligomers and longer polymers, the latter of which are characteristic of amyloid. History In 1892, Paul Blocq and Gheor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cerebral Amyloid Angiopathy -2a- Amyloid Beta - High Mag
Cerebral may refer to: * Of or relating to the brain * Cerebrum, the largest and uppermost part of the brain * Cerebral cortex, the outer layer of the cerebrum * Retroflex consonant, also referred to as a cerebral consonant, a type of consonant sound used in some languages * Intellectual, rather than emotional See also * {{Disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polymers
A polymer () is a substance or material that consists of very large molecules, or macromolecules, that are constituted by many repeating subunits derived from one or more species of monomers. Due to their broad spectrum of properties, both synthetic and natural polymers play essential and ubiquitous roles in everyday life. Polymers range from familiar synthetic plastics such as polystyrene to natural biopolymers such as DNA and proteins that are fundamental to biological structure and function. Polymers, both natural and synthetic, are created via polymerization of many small molecules, known as monomers. Their consequently large molecular mass, relative to small molecule compounds, produces unique physical properties including toughness, high elasticity, viscoelasticity, and a tendency to form amorphous and semicrystalline structures rather than crystals. Polymers are studied in the fields of polymer science (which includes polymer chemistry and polymer p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amyloid-beta Precursor Protein
Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. It functions as a cell surface receptor and has been implicated as a regulator of synapse formation, neural plasticity, antimicrobial activity, and iron export. It is coded for by the gene ''APP'' and regulated by substrate presentation. APP is best known as the precursor molecule whose proteolysis generates amyloid beta (Aβ), a polypeptide containing 37 to 49 amino acid residues, whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. Genetics Amyloid-beta precursor protein is an ancient and highly conserved protein. In humans, the gene ''APP'' is located on chromosome 21 and contains 18 exons spanning 290 kilobases. Several alternative splicing isoforms of APP have been observed in humans, ranging in length from 639 to 770 amino acids, with certain isoforms pr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Teofil Simchowicz
Teofil Simchowicz (3 June 1879 – 31 December 1957) was a Polish neurologist who was born in Ciechanowiec, near Bialystok, Poland. He studied medicine at the University of Warsaw, Imperial University of Warsaw, and received a medical degree in 1905. He worked under the founder of modern Polish school of neurology, Edward Flatau (1868-1932). It was Flatau who encouraged him to join Alois Alzheimer (1864-1915) in Munich. Simchowicz focused his research on the neuropathological changes in dementia. He emigrated with his wife to Palestine during the world war II, where he continued to work as a consulting neurologist. Simchowicz coined the terms Amyloid plaques, senile plaques, Senile (other), senile index, and granulovacuolar degeneration - discovered in the hippocampus in patients with Alzheimer's disease, and described the nasomental reflex. Simchowicz was a prolific researcher in the field of neuropathology, especially neurodegeneration but also in clinical neurology. Bib ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Birefringence
Birefringence, also called double refraction, is the optical property of a material having a refractive index that depends on the polarization and propagation direction of light. These optically anisotropic materials are described as birefringent or birefractive. The birefringence is often quantified as the maximum difference between refractive indices exhibited by the material. Crystals with non-cubic crystal structures are often birefringent, as are plastics under mechanical stress. Birefringence is responsible for the phenomenon of double refraction whereby a ray of light, when incident upon a birefringent material, is split by polarization into two rays taking slightly different paths. This effect was first described by Danish scientist Rasmus Bartholin in 1669, who observed it in Iceland spar (calcite) crystals which have one of the strongest birefringences. In the 19th century Augustin-Jean Fresnel described the phenomenon in terms of polarization, understanding ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Max Bielschowsky
Max Israel Bielschowsky (20 February 1869 – 15 August 1940) was a German neuropathologist born in Breslau. After receiving his medical doctorate from the University of Munich in 1893, he worked with Ludwig Edinger (1855–1918) at the Senckenberg Museum, Senckenberg Pathology Institute in Frankfurt-am-Main. At Senckenberg he learned histology, histological staining techniques from Carl Weigert (1845–1904). From 1896 to 1904 he worked in Emanuel Mendel's (1839–1907) psychiatric laboratory in Berlin. In 1904 he joined Oskar Vogt (1870–1959) at the neurobiology, neurobiological laboratory at the University of Berlin, where he remained until 1933. Later in his career he worked at the psychiatric clinic at the University of Utrecht, and at the Cajal Institute in Madrid. He emigrated to the UK, where he died on 15 August 1940 in the Greater London area at 71 years of age. His oldest son, Franz David Bielschowsky, also emigrated to Sheffield, UK and subsequently to Dunedin, N ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alois Alzheimer
Alois Alzheimer ( , , ; 14 June 1864 – 19 December 1915) was a German psychiatrist, neuropathologist and colleague of Emil Kraepelin. He is credited with identifying the first published case of "presenile dementia", which Kraepelin later identified as Alzheimer's disease. Early life and education Alzheimer was born in Marktbreit, Kingdom of Bavaria, Bavaria, on 14 June 1864, the son of Anna Johanna Barbara Sabina and Eduard Román Alzheimer. His father served in the office of notary public in the family's hometown. The family was devoutly Catholic Church, Catholic. The Alzheimers moved to Aschaffenburg when Alois was still young in order to give their children an opportunity to attend the Royal Humanistic Gymnasium (high school). After graduating with Abitur in 1883, Alzheimer studied medicine at Humboldt University Berlin, University of Berlin, University of Tübingen, and University of Würzburg. In his final year at university, he was a member of a fencing Studentenverbi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Actinomyces
''Actinomyces'' is a genus of the Actinomycetia class of bacteria. They all are Gram-positive and facultatively anaerobic, growing best under anaerobic conditions. ''Actinomyces'' species may form endospores, and while individual bacteria are rod-shaped, ''Actinomyces'' colonies form fungus-like branched networks of hyphae. The aspect of these colonies initially led to the incorrect assumption that the organism was a fungus and to the name ''Actinomyces'', "ray fungus" (from Greek , ray or beam, and , fungus). ''Actinomyces'' species are ubiquitous, occurring in soil and in the microbiota of animals, including the human microbiota. They are known for the important role they play in soil ecology; they produce a number of enzymes that help degrade organic plant material, lignin, and chitin. Thus, their presence is important in the formation of compost. Certain species are commensal in the skin flora, oral flora, gut flora, and vaginal flora of humans and livestock. They are also ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oskar Fischer
Oskar Fischer (12 April 1876 – 28 February 1942) was a Czech academic, psychiatrist and neuropathologist whose studies on dementia and Alzheimer's disease were rediscovered in 2008. Early life and education Fischer was born into a German-speaking Jewish family in Slaný in central Bohemia, 25 km northwest of Prague, on 12 April 1876. His father was the manager of an agricultural estate there. He completed primary and secondary education in Slaný. Then he attended the medical schools of both Prague University and Strasbourg University, and graduated from Prague University in 1900. Career Fischer began his career at the department of pathological anatomy of German University in 1900. Next, he joined the department of psychiatry of the same university in 1902, and worked there until 1919. Fischer served as a physician-in-chief at the division of neurology and psychiatry of the second garrison hospital in Prague during World War I, and treated many soldiers who had e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lesion
A lesion is any damage or abnormal change in the tissue of an organism, usually caused by injury or diseases. The term ''Lesion'' is derived from the Latin meaning "injury". Lesions may occur in both plants and animals. Types There is no designated classification or naming convention for lesions. Because lesions can occur anywhere in the body and their definition is so broad, the varieties of lesions are virtually endless. Generally, lesions may be classified by their patterns, sizes, locations, or causes. They can also be named after the person who discovered them. For example, Ghon lesions, which are found in the lungs of those with tuberculosis, are named after the lesion's discoverer, Anton Ghon. The characteristic skin lesions of a varicella zoster virus infection are called '' chickenpox''. Lesions of the teeth are usually called dental caries, or "cavities". Location Lesions are often classified by their tissue types or locations. For example, "skin lesions" or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dementia
Dementia is a syndrome associated with many neurodegenerative diseases, characterized by a general decline in cognitive abilities that affects a person's ability to perform activities of daily living, everyday activities. This typically involves problems with memory, thinking, behavior, and motor control. Aside from memory impairment and a thought disorder, disruption in thought patterns, the most common symptoms of dementia include emotional problems, difficulties with language, and decreased motivation. The symptoms may be described as occurring in a continuum (measurement), continuum over several stages. Dementia is a life-limiting condition, having a significant effect on the individual, their caregivers, and their social relationships in general. A diagnosis of dementia requires the observation of a change from a person's usual mental functioning and a greater cognitive decline than might be caused by the normal aging process. Several diseases and injuries to the brain, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
