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Aldehyde-stabilized Cryopreservation
Aldehyde-stabilized cryopreservation is a new technique for cryopreservation first demonstrated in 2016 by Robert L. McIntyre and Gregory Fahy at the cryobiology research company 21st Century Medicine, Inc. This technique uses a particular implementation of fixation and vitrification that can successfully preserve a rabbit brain in "near perfect" condition at −135 °C, with the cell membranes, synapses, and intracellular structures intact in electron micrographs. In 2016, McIntyre and Fahy were awarded the first portion of the Brain Preservation Technology Prize, the Small Animal Brain Preservation Prize, by the Brain Preservation Foundation for the successful cryopreservation of a whole mouse brain. The cryopreserved brain was rewarmed and no serious degradation was found to have occurred; the brain structure under electron microscopic evaluation after rewarming remained well-preserved. Although this technique has not yet lead to a successful revival of a cryopreserved br ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cryopreservation
Cryopreservation or cryoconservation is a process where biological material - cells, tissues, or organs - are frozen to preserve the material for an extended period of time. At low temperatures (typically or using liquid nitrogen) any cell metabolism which might cause damage to the biological material in question is effectively stopped. Cryopreservation is an effective way to transport biological samples over long distances, store samples for prolonged periods of time, and create a bank of samples for users. Molecules, referred to as cryoprotective agents (CPAs), are added to reduce the osmotic shock and physical stresses cells undergo in the freezing process. Some cryoprotective agents used in research are inspired by plants and animals in nature that have unique cold tolerance to survive harsh winters, including: trees, wood frogs, and tardigrades. The first human corpse to be frozen with the hope of future resurrection was James Bedford's, a few hours after his c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gregory Fahy
Gregory Michael Fahy is a California-based cryobiologist, biogerontologist, and businessman. He is the Vice President and Chief Scientific Officer at 21st Century Medicine, Inc, and has co-founded ''Intervene Immune'', a company developing clinical methods to reverse immune system aging. He was the 2022–2023 president of the Society for Cryobiology. Education A native of California, Fahy holds a Bachelor of Science degree in biology from the University of California, Irvine and a PhD in pharmacology and cryobiology from the Medical College of Georgia in Augusta. He currently serves on the board of directors of two organizations and as a referee for numerous scientific journals and funding agencies, and holds 35 patents on cryopreservation methods, aging interventions, transplantation, and other topics. Career Fahy is the world's foremost expert in organ cryopreservation by vitrification. Fahy introduced the modern successful approach to vitrification for cryopreservation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cryobiology
Cryobiology is the branch of biology that studies the effects of low temperatures on living things within Earth's cryosphere or in science. The word cryobiology is derived from the Greek words κρῧος ryos "cold", βίος ios "life", and λόγος ogos "word". In practice, cryobiology is the study of biological material or systems at temperatures below normal. Materials or systems studied may include proteins, cells, tissues, organs, or whole organisms. Temperatures may range from moderately hypothermic conditions to cryogenic temperatures. Areas of study At least six major areas of cryobiology can be identified: 1) study of cold-adaptation of microorganisms, plants ( cold hardiness), and animals, both invertebrates and vertebrates (including hibernation), 2) cryopreservation of cells, tissues, gametes, and embryos of animal and human origin for (medical) purposes of long-term storage by cooling to temperatures below the freezing point of water. This usually requir ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
21st Century Medicine
21st Century Medicine (21CM) is a California cryobiological research company which has as its primary focus the development of perfusates and protocols for viable long-term cryopreservation of human organs, tissues and cells at temperatures below −100 °C through the use of vitrification. 21CM was founded in 1993. In 2004 21CM received a $900,000 grant from the U.S. National Institutes of Health (NIH) to study a preservation solution developed by the University of Rochester in New York for extending simple cold storage time of human hearts removed for transplant. At the July 2005 annual conference of the Society for Cryobiology, 21st Century Medicine announced the vitrification of a rabbit kidney to −135 °C with their vitrification mixture. The kidney was successfully transplanted upon rewarming to a rabbit, the rabbit being euthanized on the 48th day for histological Histology, also known as microscopic anatomy or microanatomy, is the branch of biology ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Degree Celsius
The degree Celsius is the unit of temperature on the Celsius temperature scale "Celsius temperature scale, also called centigrade temperature scale, scale based on 0 ° for the melting point of water and 100 ° for the boiling point of water at 1 atm pressure." (originally known as the centigrade scale outside Sweden), one of two temperature scales used in the International System of Units (SI), the other being the closely related Kelvin scale. The degree Celsius (symbol: °C) can refer to a specific point on the Celsius temperature scale or to a difference or range between two temperatures. It is named after the Swedish astronomer Anders Celsius (1701–1744), who proposed the first version of it in 1742. The unit was called ''centigrade'' in several languages (from the Latin ''centum'', which means 100, and ''gradus'', which means steps) for many years. In 1948, the International Committee for Weights and Measures renamed it to honor Celsius and also to remove ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brain Preservation Foundation
The Brain Preservation Foundation is an American non-profit organization with the goal of promoting validated scientific research and technical services development in the field of whole brain preservation for long-term static storage, as well as working on the accessibility, affordability, and sustainability of this technology. It also provides public education on topics such as the neural foundations of memory, brain scanning techniques, brain preservation, and mind uploading. Prizes In 2010, the Brain Preservation Foundation launched an inducement prize contest with the goal of improving the long-run preservation of human brains. The purpose of preserving a human brain is to allow the mind uploading of the preserved brain's long-term memories if the technology becomes available to do so in the long-run future. The requirements of the Brain Preservation Technology Prize stated that the connectome of a brain had to be preserved in a way that would allow for long-term storage (> ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Popular Science
Popular science (also called pop-science or popsci) is an interpretation of science intended for a general audience. While science journalism focuses on recent scientific developments, popular science is more broad ranging. It may be written by professional science journalists or by scientists themselves. It is presented in many forms, including books, film and television documentaries, magazine articles, and web pages. History Before the modern specialization and professionalization of science, there was often little distinction between "science" and "popular science", and works intended to share scientific knowledge with a general reader existed as far back as Greek and Roman antiquity. Without these popular works, much of the scientific knowledge of the era might have been lost. For example, none of the original works of the Greek astronomer Eudoxus (4th century BC) have survived, but his contributions were largely preserved due to the didactic poem '' Phenomena'' writte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scientific American
''Scientific American'', informally abbreviated ''SciAm'' or sometimes ''SA'', is an American popular science magazine. Many scientists, including Albert Einstein and Nikola Tesla, have contributed articles to it, with more than 150 Nobel Prize-winners being featured since its inception. In print since 1845, it is the oldest continuously published magazine in the United States. ''Scientific American'' is owned by Springer Nature, which is a subsidiary of Holtzbrinck Publishing Group. History ''Scientific American'' was founded by inventor and publisher Rufus Porter (painter), Rufus Porter in 1845 as a four-page weekly newspaper. The first issue of the large-format New York City newspaper was released on August 28, 1845. Throughout its early years, much emphasis was placed on reports of what was going on at the United States Patent and Trademark Office, U.S. Patent Office. It also reported on a broad range of inventions including perpetual motion machines, an 1860 devi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cryonics
Cryonics (from ''kryos'', meaning "cold") is the low-temperature freezing (usually at ) and storage of human remains in the hope that resurrection may be possible in the future. Cryonics is regarded with skepticism by the mainstream scientific community. It is generally viewed as a pseudoscience, and its practice has been characterized as quackery. Cryonics procedures can begin only after the "patients" are clinically and legally dead. Procedures may begin within minutes of death, and use cryoprotectants to try to prevent ice formation during cryopreservation. It is not possible to reanimate a corpse that has undergone vitrification, as this damages the brain, including its neural circuits. The first corpse to be frozen was that of James Bedford, in 1967. As of 2014, remains from about 250 bodies had been cryopreserved in the United States, and 1,500 people had made arrangements for cryopreservation of theirs. Even if the resurrection promised by cryonics were pos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
